Notum Pectinacetylesterase Homolog (Drosophila) Protéines (NOTUM)

May deacetylate GlcNAc residues on cell surface glycans (Potential).. De plus, nous expédions NOTUM Anticorps (47) et NOTUM Kits (6) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NOTUM 147111 Q6P988
NOTUM 77583 Q8R116
Rat NOTUM NOTUM 303743  
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Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Détails
Wheat germ Humain GST tag 2 μg 11 to 12 Days
$338.33
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Détails

NOTUM Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Notum Pectinacetylesterase Homolog (Drosophila) (NOTUM) partenaires d'interaction

Human Notum Pectinacetylesterase Homolog (Drosophila) (NOTUM) interaction partners

  1. results reveal a role of the stem cell niche in ageing and demonstrate that targeting of Notum can promote regeneration of aged tissues

  2. NOTUM expression was increased in metastatic cells. Proliferation was suppressed by inhibiting expression of NOTUM. Knockdown of NOTUM genes inhibited proliferation as well as migration, with possible involvement of p38 and c-JUN N-terminal kinase in this process.

  3. Data show that notum and glypican-1 and glypican-3 gene expression during colorectal cancer (CRC) development and present evidence to suggest them as potential new biomarkers of CRC pathogenesis.

  4. Kinetic and mass spectrometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitutes the first known extracellular protein deacylase

  5. Overexpression of NOTUM is associated with hepatocellular carcinoma

Mouse (Murine) Notum Pectinacetylesterase Homolog (Drosophila) (NOTUM) interaction partners

  1. results reveal a role of the stem cell niche in ageing and demonstrate that targeting of Notum can promote regeneration of aged tissues

  2. Notum influences mesenchymal cell differentiation by generating a barrier for Wnt ligands produced and secreted by airway epithelial cells to attenuate Wnt signaling.

  3. The findings support a significant role for NOTUM in modulating WNT signaling pathways that have pleiotropic effects on tooth and kidney development.

  4. Data show that notum and glypican-1 and glypican-3 gene expression during colorectal cancer (CRC) development and present evidence to suggest them as potential new biomarkers of CRC pathogenesis.

  5. Male mice deficient in Notum specifically in the liver develop metabolic dysfunctions implicating Notum in the development of Type 2 diabetes.

  6. Describes the human ortholog, and analyzes both the human and mouse promoters.

Profil protéine NOTUM

Profil protéine

May deacetylate GlcNAc residues on cell surface glycans (Potential).

Gene names and symbols associated with NOTUM

  • notum, palmitoleoyl-protein carboxylesterase (NOTUM)
  • notum pectinacetylesterase homolog (Drosophila) (Notum)
  • NOTUM, palmitoleoyl-protein carboxylesterase (Notum)
  • 5730593N15Rik Protéine
  • RGD1307119 Protéine

Protein level used designations for NOTUM

protein notum homolog , notum pectinacetylesterase homolog

GENE ID SPECIES
147111 Homo sapiens
77583 Mus musculus
303743 Rattus norvegicus
483374 Canis lupus familiaris
525682 Bos taurus
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