Nuclear Autoantigenic Sperm Protein (Histone-Binding) Protéines (NASP)

NASP encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. De plus, nous expédions Nuclear Autoantigenic Sperm Protein (Histone-Binding) Anticorps (54) et Nuclear Autoantigenic Sperm Protein (Histone-Binding) Kits (8) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NASP 4678 P49321
NASP 50927 Q99MD9
NASP 298441 Q66HD3
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Top Nuclear Autoantigenic Sperm Protein (Histone-Binding) Protéines sur anticorps-enligne.fr

Showing 7 out of 9 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$340.00
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Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$560.00
Détails
Escherichia coli (E. coli) Humain Inconjugué SDS-PAGE analysis of Human NASP Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$582.75
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Escherichia coli (E. coli) Rat Inconjugué SDS-PAGE analysis of Rat NASP Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$682.25
Détails

NASP Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour Nuclear Autoantigenic Sperm Protein (Histone-Binding) (NASP) partenaires d'interaction

Human Nuclear Autoantigenic Sperm Protein (Histone-Binding) (NASP) interaction partners

  1. Results found that NASP expression levels were upregulated in liver tumors. Its down-regulation inhibited liver cells from forming tumors. Also, NASP depletion led to a global decrease of histone H3K9me1 modification associated with newly H3 processing, which occurred directly at the promoters of up-regulated anti-tumor genes BACH2 and RunX1T1.

  2. NASP is targeted by miR-29c in gastric cancer cells. miR-29c can decrease NASP expression and the effects observed following miR-29c overexpression are partially due to NASP depletion.

  3. findings reveal a new mode of interaction between a TPR repeat domain of histone chaperone sNASP and an evolutionarily conserved peptide motif found in canonical H3 and in all histone H3 variants

  4. Our research demonstrates that knockdown of tNASP effectively inhibits the proliferation and causes G1 phase arrest through ERK/MAPK signal pathway.

  5. These results provide evidence that tNASP is ubiquitously produced in various types of human tissues and promotes in vitro nucleosome assembly with H3 variant specificity.

  6. NASP family Proteins are highly conserved throughout the eukaryotes and posses four TPR motifs. It was likely present in the last common ancestor of eukaryotes possibly representing an important innovation regarding H3/H4 transport mechanism. Different TPR motifs in NASP have evolved at different rates with TPR1/4 evolving faster than TPR2/3.

  7. Studies indicate that histone chalerones nucleoplasmin (NPM2/NPM3) preferentially associated with histones H2A-H2B in the egg and the nuclear autoantigenic sperm protein (NASP) families.

  8. an increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development.

  9. sNASP interacts with linker and core histones through distinct structural domains.

  10. The insights into NASP function and the existence of a tunable reservoir in mammalian cells demonstrate that contingency is integrated into the histone supply chain to respond to unexpected changes in demand.

  11. tNASP is critical for the survival of prostate cancer cells; targeting tNASP expression can lead to a new approach for prostate cancer treatment.

  12. NASP and RCAS1 proteins were more frequently expressed in ovarian cancer tissues than with normal ovarian tissue and serous cystadenomas and MRE11 was less frequently expressed

  13. A deletion analysis of sNASP revealed that the central region, amino acid residues 26-325, of sNASP is responsible for nucleosome assembly in vitro.

  14. NASP and the linker histones are key players in the assembly of chromatin after DNA replication

  15. NASP forms distinct, high specificity complexes with histones H3 and H4.

  16. NASP belongs to a network of genes and gene functions that are critical for cell survival

Mouse (Murine) Nuclear Autoantigenic Sperm Protein (Histone-Binding) (NASP) interaction partners

  1. an increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development.

  2. NASP controls the ability of HSPA2 to activate CDC2 for CDC2/cyclin B1 complex formation; therefore, tNASP's role is to provide the functional link between linker histones and cell cycle progression during meiosis.

  3. overexpression affects progression through cell cycle

  4. in the cytoplasm linker histones are bound to a complex containing NASP and HSP90 whose ATPase activity is stimulated by binding NASP

  5. Sp1 and Ets are the primary activators of the NASP promoter.

  6. NASP and the linker histones are key players in the assembly of chromatin after DNA replication

Cow (Bovine) Nuclear Autoantigenic Sperm Protein (Histone-Binding) (NASP) interaction partners

  1. NASP mRNA expression is required for preimplantation development into the blastocyst stage in cattle.

Profil protéine Nuclear Autoantigenic Sperm Protein (Histone-Binding) (NASP)

Profil protéine

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.

Gene names and symbols associated with NASP

  • nuclear autoantigenic sperm protein (NASP)
  • nuclear autoantigenic sperm protein (histone-binding) (Nasp)
  • nuclear autoantigenic sperm protein (Nasp)
  • nuclear autoantigenic sperm protein (histone-binding) (nasp)
  • 5033430J04Rik Protéine
  • AI131596 Protéine
  • AI317140 Protéine
  • D4Ertd767e Protéine
  • Epcs32 Protéine
  • FLB7527 Protéine
  • Nasp-T Protéine
  • PRO1999 Protéine
  • wu:fd20g12 Protéine
  • zgc:56007 Protéine
  • zgc:85651 Protéine

Protein level used designations for NASP

nuclear autoantigenic sperm protein (histone-binding) , histone H1-binding protein , nuclear autoantigenic sperm protein , somatic histone binding protein NASP

GENE ID SPECIES
741511 Pan troglodytes
4678 Homo sapiens
50927 Mus musculus
298441 Rattus norvegicus
799570 Danio rerio
424600 Gallus gallus
475373 Canis lupus familiaris
512427 Bos taurus
100009592 Oryctolagus cuniculus
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