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NUCKS1 encodes a nuclear protein that is highly conserved in vertebrates.
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High NUCKS1 expression is associated with drug resistance in lung cancer.
NUCKS overexpression had prognostic potential for overall survival and disease-free survival in advanced ovarian cancers and only for disease-free survival in early ovarian cancers . Our data suggest that NUCKS overexpression may contribute to progression and poor prognosis in ovarian cancer especially in advanced ovarian cancer
NUCKS1 was identified as a potential oncogene (Montrer RAB1A Anticorps) at chromosomal 1q32.1 in patients with HCC (Montrer FAM126A Anticorps), and it might be a valuable immunodiagnostic marker for HCC (Montrer FAM126A Anticorps)
The results show that NUCKS1 is a chromatin-associated protein with a role in the DNA damage response and in homologous recombination, a DNA repair pathway critical for tumor suppression.
NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II (Montrer 0 Anticorps) recruitment to the promoters of IR and other insulin (Montrer INS Anticorps) pathway modulators.
NUCKS1 expression did not increase Tat (Montrer TAT Anticorps) nuclear localization.
NUCKS1 overexpression may be associated with tumour progression and recurrence in cervical squamous cell carcinoma
NUCKS-1 overexpression is associated with obesity and with breast cancer.
We would like to emphasize that NUCKS abundance in malignant skin tumors is higher than that of the well-known proliferation marker Ki67 (Montrer MKI67 Anticorps), thus allowing more precise assessment of tumor proliferation potential.
Authors suggest that NUCKS is involved in cellular responses following PDT (Montrer TWIST1 Anticorps).
in the context of Trp53 (Montrer TP53 Anticorps) deficiency, wild type levels of Nucks1 are required to suppress radiation-induced thymic lymphoma, likely through the role of the NUCKS1 protein in the DNA damage response
This study demonstrates that depletion of NUCKS enhances the therapeutic efficacy of Bone marrow-derived mesenchymal stem cells for myocardial infarction via regulating the secretion of VEGFa (Montrer VEGFA Anticorps).
Hypothalamic NUCKS plays an essential role in regulating glucose homoeostasis and insulin (Montrer INS Anticorps) signaling.
The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax (Montrer BAX Anticorps) levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis.
This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle.
nuclear ubiquitous casein and cyclin-dependent kinases substrate
, nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate
, nuclear casein kinase and cyclin-dependent kinase substrate 1
, nuclear ubiquitous casein and cyclin-dependent kinase substrate
, Nuclear ubiquitous casein and cyclin-dependent kinases substrate
, nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
, potential LAG1 interactor
, nuclear, casein kinase and cyclin-dependent kinase substrate
, cyclin-dependent kinase substrate
, nuclear ubiquitous casein kinase 2