Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1 Protéines (NUCKS1)

NUCKS1 encodes a nuclear protein that is highly conserved in vertebrates. De plus, nous expédions Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1 Anticorps (56) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NUCKS1 64710 Q9H1E3
NUCKS1 98415 Q80XU3
NUCKS1 64709 Q9EPJ0
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Top Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1 Protéines sur anticorps-enligne.fr

Showing 6 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,227.64
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,227.64
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Détails
Levure Boeuf (Vache) His tag   1 mg 60 to 71 Days
$2,619.83
Détails
Levure Rat His tag   1 mg 60 to 71 Days
$2,619.83
Détails

NUCKS1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1 (NUCKS1) partenaires d'interaction

Human Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1 (NUCKS1) interaction partners

  1. The insulin-like growth factor 1 receptor (IGF-1R) gene was found to be a potential downstream target of NUCKS1 in GC cells.

  2. Chinese patients with allele T of rs951366 on the NUCKS1 gene are more vulnerable to the incidence of adolescent idiopathic sclerosis as well as late onset of menarche.

  3. NUCKS1 may be involved in DNA double-strand breakage repair and/or inflammatory signaling in ulcerative colitis

  4. our results suggested that there was a significant association of a minor allele (G) in rs823114 with reduced risk of Parkinson's disease development (P = 0.017, OR = 0.768, 95%CI = 0.618 - 0.955). We conclude that NUCKS1 rs823114 indicates a decreased risk of susceptibility to Parkinson's disease and shows a male genetic distribution bias in the Han Chinese population.

  5. High NUCKS1 expression is associated with drug resistance in lung cancer.

  6. NUCKS overexpression had prognostic potential for overall survival and disease-free survival in advanced ovarian cancers and only for disease-free survival in early ovarian cancers . Our data suggest that NUCKS overexpression may contribute to progression and poor prognosis in ovarian cancer especially in advanced ovarian cancer

  7. NUCKS1 was identified as a potential oncogene at chromosomal 1q32.1 in patients with HCC, and it might be a valuable immunodiagnostic marker for HCC

  8. The results show that NUCKS1 is a chromatin-associated protein with a role in the DNA damage response and in homologous recombination, a DNA repair pathway critical for tumor suppression.

  9. NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin pathway modulators.

  10. NUCKS1 expression did not increase Tat nuclear localization.

  11. NUCKS1 overexpression may be associated with tumour progression and recurrence in cervical squamous cell carcinoma

  12. NUCKS-1 overexpression is associated with obesity and with breast cancer.

  13. We would like to emphasize that NUCKS abundance in malignant skin tumors is higher than that of the well-known proliferation marker Ki67, thus allowing more precise assessment of tumor proliferation potential.

  14. Authors suggest that NUCKS is involved in cellular responses following PDT.

  15. The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis.

  16. Through a combination of gene expression and copy number analysis, NUCKS1 was identified as a candidate gene involved in the distant metastasis of colorectal cancer.

  17. The results show overexpression of the NUCKS protein and RNA in a number of non malignant breast lesions and cancerous tissues. In particular, the NUCKS overexpression in ADH and DCIS indicates a significant role of this protein in neoplastic progression.

  18. Overexpression of NUCKS can play significant role in breast cancer biology.

  19. Two putative nuclear localization signals have been identified and characterized in NUCKS.

  20. NUCKS appears to have the highest ratio of modified to unmodified residues of any protein so far described.

Mouse (Murine) Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1 (NUCKS1) interaction partners

  1. Study describes the role of NUCKS in corneal wound healing, inflammation and angiogenesis and links NUCKS to the activation of NF-kappa B and modulation of various cytokines.

  2. in the context of Trp53 deficiency, wild type levels of Nucks1 are required to suppress radiation-induced thymic lymphoma, likely through the role of the NUCKS1 protein in the DNA damage response

  3. This study demonstrates that depletion of NUCKS enhances the therapeutic efficacy of Bone marrow-derived mesenchymal stem cells for myocardial infarction via regulating the secretion of VEGFa.

  4. Hypothalamic NUCKS plays an essential role in regulating glucose homoeostasis and insulin signaling.

  5. NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin pathway modulators.

  6. The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis.

Profil protéine Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1 (NUCKS1)

Profil protéine

This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle.

Gene names and symbols associated with NUCKS1

  • nuclear casein kinase and cyclin dependent kinase substrate 1 (NUCKS1)
  • nuclear casein kinase and cyclin-dependent kinase substrate 1 L homeolog (nucks1.L)
  • nuclear casein kinase and cyclin-dependent kinase substrate 1a (nucks1a)
  • nuclear casein kinase and cyclin-dependent kinase substrate 1 (nucks1)
  • nuclear casein kinase and cyclin dependent kinase substrate 1 (nucks1)
  • nuclear casein kinase and cyclin-dependent kinase substrate 1 (Nucks1)
  • 2700010L10Rik Protéine
  • 8430423A01Rik Protéine
  • AI647518 Protéine
  • C78391 Protéine
  • fc07e02 Protéine
  • jc7 Protéine
  • MGC131005 Protéine
  • Nucks Protéine
  • nucks1 Protéine
  • wu:fb16a10 Protéine
  • wu:fb16h08 Protéine
  • wu:fb36b01 Protéine
  • wu:fb82a01 Protéine
  • wu:fc07e02 Protéine
  • wu:fe37f10 Protéine
  • wu:gcd26e12 Protéine
  • zgc:86878 Protéine

Protein level used designations for NUCKS1

nuclear ubiquitous casein and cyclin-dependent kinases substrate , nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate , nuclear casein kinase and cyclin-dependent kinase substrate 1 , nuclear ubiquitous casein and cyclin-dependent kinase substrate , Nuclear ubiquitous casein and cyclin-dependent kinases substrate , P1 , nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 , potential LAG1 interactor , JC7 , nuclear, casein kinase and cyclin-dependent kinase substrate , cyclin-dependent kinase substrate , nuclear ubiquitous casein kinase 2

GENE ID SPECIES
404775 Gallus gallus
414674 Xenopus laevis
447862 Danio rerio
457673 Pan troglodytes
478944 Canis lupus familiaris
697298 Macaca mulatta
100227548 Taeniopygia guttata
394795 Xenopus (Silurana) tropicalis
100195126 Salmo salar
64710 Homo sapiens
98415 Mus musculus
64709 Rattus norvegicus
505585 Bos taurus
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