Nuclear Factor (Erythroid-Derived 2), 45kDa Protéines (NFE2)

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. De plus, nous expédions NFE2 Anticorps (42) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NFE2 4778 Q16621
NFE2 18022 Q07279
Rat NFE2 NFE2 366998 Q6AYT2
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Top NFE2 Protéines sur anticorps-enligne.fr

Showing 6 out of 7 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,570.39
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,570.39
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$340.00
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Détails
Levure Bactéries His tag   1 mg 60 to 71 Days
$2,830.67
Détails
Levure Boeuf (Vache) His tag   1 mg 60 to 71 Days
$3,026.83
Détails

NFE2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Nuclear Factor (Erythroid-Derived 2), 45kDa (NFE2) partenaires d'interaction

Human Nuclear Factor (Erythroid-Derived 2), 45kDa (NFE2) interaction partners

  1. mutations in NFE2 predispose to the acquisition of secondary changes promoting the development of myelosarcoma and/or AML

  2. We detected that cigarette smoke significantly increased p45 NFE2 levels in DJ-1 KO mice compared to wild-type mice. Our results indicate that p45 NFE2 expression is induced by exposure to cigarette smoke, has a cytoprotective activity against cell injury, and its downregulation in human primary ATII cells may contribute to emphysema pathogenesis

  3. NF-E2 silencing in hematopoietic stem and progenitor cells (HSPCs) did not affect their myeloid and B cell differentiation in vivo, it almost abrogated T cell production in primary hosts, as confirmed by in vitro studies. This effect is at least partly due to Notch1 downregulation in NF-E2-silenced HSPCs.

  4. results suggest that p45 NF-E2 negatively regulates differentiation and apoptosis activation of human syncytiotrophoblast by modulating GCM1 acetylation and sumoylation.

  5. NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR

  6. under the obese condition, activation of the hepatic NFE2/miR-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A-ATP-Akt signaling pathway.

  7. Our data presented herein support the hypothesis that cytoplasmically located NF-E2 may have a function in the elimination of internal organelles. The mild autophagy defect observed in our mice may be due to the requirement for additional proteins in the formation of larger complexes to exert this function.

  8. assessment of NF-E2 and NGFR expression may provide additional support in reaching a correct diagnosis in discriminating polycythemia vera from prefibrotic/fibrotic primary myelofibrosis and essential thrombocythemia

  9. The genes BCL6, NFE2, POU4F2 and ELF4 are primary 1,25(OH)2D3 targets in THP-1 cells

  10. the RUNX1 target NF-E2 is part of the molecular network by which RUNX1 regulates platelet biogenesis and function in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia

  11. A functional link among the erythroid transcription factors GATA-1/NF-E2, miR-199b-5p in erythropoiesis.

  12. NF-E2 immunohistochemistry and analysis of the proportion of nuclear positive erythroblasts of all erythroid precursor cells can help to distinguish between ET and PMF even in early stages of the diseases.

  13. NFE-2 transgene mediates the expression of interleukin 8 in myeloproliferative neoplasms, thereby contributing to myeloproliferative neoplasm pathology.

  14. Findings suggest a model whereby ROCK inhibition drives polyploidization, DMS growth and proplatelet formation late in megakaryocyte maturation through downregulation of MYC and NFE2 expression.

  15. IFN-gamma modulates NF-kappaB/c-Jun to antagonize activin A-mediated NF-E2 transcriptional activity on erythroid cell globin gene expression.

  16. RUNX1 and NF-E2 are overexpressed in polycythemic patients of diverse phenotypes and molecular causes

  17. Here we demonstrate that NF-E2 is mislocalized in prefibrotic primary myelofibrosis cells and that aberrant NF-E2 localization discriminates statistically highly significantly between essential thrombocytthemia and that disease.

  18. the role of increased NF-E2 activity in the pathophysiology of myeloproliferative neoplasms, is reported.

  19. NF-E2 overexpression is both required and sufficient for Epo independence and hematopoietic stem cells/myeloid progenitor cell expansion in polycythemia vera.

  20. These findings demonstrate that a combination of p45NF-E2, Maf G, and Maf K is a key determinant of both megakaryopoiesis and thrombopoiesis.

Mouse (Murine) Nuclear Factor (Erythroid-Derived 2), 45kDa (NFE2) interaction partners

  1. mutations in NFE2 predispose to the acquisition of secondary changes promoting the development of myelosarcoma and/or AML

  2. We detected that cigarette smoke significantly increased p45 NFE2 levels in DJ-1 KO mice compared to wild-type mice. Our results indicate that p45 NFE2 expression is induced by exposure to cigarette smoke, has a cytoprotective activity against cell injury, and its downregulation in human primary ATII cells may contribute to emphysema pathogenesis

  3. Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1, FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.

  4. Under the obese condition, activation of the hepatic NFE2/miR-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A-ATP-Akt signaling pathway.

  5. results suggest that Nrf2 deficiency induced by HFD promoted hepatic fatty acid metabolism disorder by altering 18-carbon and 22-carbon fatty acid composition

  6. A novel murine model may excellently describe the deleterious impact of sustained chronic NF-E2 overexpression during uncontrolled chronic inflammation upon the hematopoietic system--the development of clonal myeloproliferation.

  7. Although none of the parameters measured were different between the NF-E2 deficient and control mice, an increase in calcium (21%) and an increase in the mineral/matrix ratio (32%) was observed in GATA-1 deficient mice.

  8. By activating genes in megakaryocytes that mediate platelet production and function, NF-E2 p45 determines the quantity and quality of platelets.

  9. maintaining expression of intestinal epithelial cell prohibitin reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 and NQO-1 via a mechanism independent of Nfe2

  10. These findings demonstrate that a combination of p45NF-E2, Maf G, and Maf K is a key determinant of both megakaryopoiesis and thrombopoiesis.

  11. Loss of p45 NF-E2 leads to a 2-fold increase in serum erythropoietin & increased splenic erythropoiesis. Erythroid cells were arrested at the G(1) stage of cell cycle.

  12. Nfe2 modulates JunD binding to the Gcm1 promoter via acetylation

  13. studies identify a novel function of p45NF-E2 during placental development: in trophoblast cells, p45NF-E2 represses Gcm1 and syncytiotrophoblast formation via acetylation

  14. NLS-dependent nuclear import of p45 NF-E2 is important for platelet development

  15. USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus.

  16. Data suggest that GATA1 or other factors regulated by GATA1 are required to cooperate with p45 for normal megakaryopoiesis.

  17. Data suggest that the posttranslational modifications and turnover of p45/NF-E2, as mediated by P-JNK, contribute to the control of its homeostatic concentration and consequently, its regulatory functions.

  18. hematopoietic-specific activators NF-E2 and GATA-1, which mediate transactivation of the beta-globin genes, induce both histone acetylation and H3-meK4

  19. Chromatin immunoprecipitation demonstrates recruitment of NF-E2 to the putative Rab27B promoter

  20. Cells of the osteoblast lineage do not express NF-E2 mRNA. A megakaryocyte-osteoblast interaction occurs in NF-E2- deficient mice which is anabolic for bone.

Profil protéine NFE2

Profil protéine

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

Gene names and symbols associated with NFE2

  • nuclear factor, erythroid 2 (NFE2)
  • nuclear factor, erythroid derived 2 (Nfe2)
  • nuclear factor, erythroid 2 (Nfe2)
  • 45kDa Protéine
  • NF-E2 Protéine
  • p45 Protéine
  • p45nf-e2 Protéine
  • p45NFE2 Protéine

Protein level used designations for NFE2

leucine zipper protein NF-E2 , nuclear factor, erythroid derived 2 , nuclear factor, erythroid-derived 2 45 kDa subunit , p45 NF-E2 , transcription factor NF-E2 45 kDa subunit , nuclear factor (erythroid-derived 2), 45kD , nuclear factor (erythroid-derived 2), 45kDa , nuclear factor, erythroid derived 2, 45 kDa

GENE ID SPECIES
486495 Canis lupus familiaris
514006 Bos taurus
4778 Homo sapiens
18022 Mus musculus
366998 Rattus norvegicus
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