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Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. De plus, nous expédions Nuclear Prelamin A Recognition Factor-Like Anticorps (53) et Nuclear Prelamin A Recognition Factor-Like Kits (10) et beaucoup plus de produits pour cette protéine.
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we concluded that the Ser161Ile mutant induced NARFL deficiency and eventually diffuse PAVMs probably through VEGF pathway. In a word, we detected a functional mutation in NARFL, which might be the pathogenic gene in this pedigree.
MMS19 interacts with target proteins. MIP18 has a role to bridge MMS19 and CIAO1. CIAO1 also binds IOP1.
IOP1 is involved in mammalian cytosolic Fe-S protein maturation.
human IscA1 plays an important role in both mitochondrial and cytosolic iron-sulfur cluster biogenesis, and a notable component of the latter is the interaction between IscA1 and IOP1.
knock-out of Iop1/Narfl in mice results in lethality and defective cytosolic iron-sulfur cluster assembly. The findings demonstrate an essential role for IOP1 in this pathway.
Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity).
nuclear prelamin A recognition factor-like
, LET1 like/JFP15
, cytosolic Fe-S cluster assembly factor NARFL
, iron-only hydrogenase-like protein 1
, nuclear prelamin A recognition factor-like protein
, protein related to Narf
, cytosolic Fe-S cluster assembly factor narfl