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The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. De plus, nous expédions Nucleoporin 54kDa Anticorps (20) et et beaucoup plus de produits pour cette protéine.
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Data indicate a role for nucleoporin 54 (Nup54) in the response to ionising radiation (IR) and the maintenance of homologous recombination repair mediated genome integrity.
Mutations within the footprinted region of Nup54 polymers blocked both polymerization and binding by the PRn poly-dipeptide. 1,6-hexanediol melted FG domain polymers in vitro and reversed PRn-mediated enhancement of the nuclear pore permeability barrier, suggesting that toxicity of the PRn poly-dipeptide results in part from its ability to lock the FG repeats of nuclear pore proteins in the polymerized state.
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset.
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