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The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. De plus, nous expédions Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal NACC1 Primary Antibody pour ICC, FACS - ABIN259549
Nakayama, Nakayama, Davidson, Sheu, Jinawath, Santillan, Salani, Bristow, Morin, Kurman, Wang, Shih: A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. dans Proceedings of the National Academy of Sciences of the United States of America 2006
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Human Polyclonal NACC1 Primary Antibody pour ELISA, WB - ABIN188846
Wang, Rao, Chu, Shen, Levasseur, Theunissen, Orkin: A protein interaction network for pluripotency of embryonic stem cells. dans Nature 2006
knockdown of HOXA9 (Montrer HOXA9 Anticorps) abrogated NAC1induced drug resistance.
NAC1 forms a protein complex to function as a transcriptional regulator in cancer cells
a mutation in NACC1 causes microcephaly, profound developmental delays and/or intellectual disability, cataracts, severe epilepsy including infantile spasms, irritability, failure to thrive, and stereotypic hand movements
miR (Montrer MLXIP Anticorps)-339-5p inhibits migration and invasion in ovarian cancer by targeting NACC1 and BCL6 (Montrer BCL6 Anticorps). miR (Montrer MLXIP Anticorps)-339-5p may be a biomarker of metastasis in ovarian cancer; NACC1 had a predictive value for ovarian cancer progression
NAC1 has potential as a marker for distinguishing OED from CIS (Montrer CISH Anticorps)/OSCC
NACC1 can be modified by SUMO paralogues, and cooperates with promyelocytic leukemia protein (Montrer PML Anticorps).
strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1 (Montrer ZBTB17 Anticorps)/BCL6 (Montrer BCL6 Anticorps) and of Miz1 (Montrer ZBTB17 Anticorps)/NAC1 are reported
NAC1 is essential and sufficient for activation of FOXQ1 (Montrer FOXQ1 Anticorps)
low expression of NAC1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma.
The identification of an NAC1 NLS (Montrer ALDH1A2 Anticorps) thus clarifies the mechanism through which NAC1 translocates to the nucleus to regulate the transcription of genes involved in oncogenicity and pluripotency.
NAC1 downregulates the E-cadherin (Montrer CDH1 Anticorps) repressor ZEB1 (Montrer ZEB1 Anticorps) directly via transcriptional repression.
Nac1 overexpression promotes ESC proliferation and delays ESC differentiation in the absence of leukemia inhibitory factor (LIF (Montrer LIF Anticorps)). Furthermore, we demonstrated that Nac1 directly binds to the c-Myc (Montrer MYC Anticorps) promoter and regulates c-Myc (Montrer MYC Anticorps) transcription.
a sub-network of four factors, Nac1, Oct4 (Montrer POU5F1 Anticorps), Tcf3 (Montrer TCF7L1 Anticorps), and Sox2 (Montrer SOX2 Anticorps), regulates mouse embryonic stem cell differentiation into the alternative mesendodermal and neuroectodermal fates.
The interaction of Nac1 with Miz1 (Montrer PIAS2 Anticorps) may thus be relevant to its mechanism of tumourigenesis in ovarian cancer.
NAC1 participates in the motility and differentiation of developing chondrocytes and cartilaginous tissues, and its expression is necessary to maintain normal axial patterning of murine skeleton.
The mouse Nac1 gene consist of six exons, with exon 2 containing an alternative splice donor, providing a molecular explanation of the splice variants observed in mouse and rat.
these data indicate involvement of NAC1 in the acute behavioral and neurochemical responses to psychomotor stimulants
Nanog (Montrer NANOG Anticorps) interacts with Nac1 through WNAAP to regulate the cell cycle of stem cells via the ERas/phosphatidylinositol 3-kinase/Akt (Montrer AKT1 Anticorps) pathway, but not pluripotency
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9.
BEN domain containing 8
, BTB/POZ domain-containing protein 14B
, nucleus accumbens-associated protein 1
, transcriptional repressor NAC1
, nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
, BTB (POZ) domain containing 14B
, nucleus accumbens-1