OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) Protéines (OMA1)

Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. De plus, nous expédions OMA1 Anticorps (19) et OMA1 Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
OMA1 115209 Q96E52
Rat OMA1 OMA1 298282 D3ZS74
OMA1 67013 Q9D8H7
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,355.45
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,626.01
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Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
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OMA1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) (OMA1) partenaires d'interaction

Human OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) (OMA1) interaction partners

  1. differential stress-induced degradation of YME1L (Montrer YME1L1 Protéines) and OMA1 as a mechanism for sensitively adapting mitochondrial inner membrane protease activity and function in response to distinct types of cellular insults.

  2. The mitochondrial metalloprotease OMA1 was activated in a Bax (Montrer BAX Protéines)- and Bak (Montrer BAK1 Protéines)-dependent fashion.

  3. Cleavage of the inner membrane fusion factor L-OPA1 (Montrer OPA1 Protéines) is prevented due to the failure to activate the inner membrane protease OMA1 in mitochondria that have a collapsed membrane potential.

  4. OMA1 is cleaved to a short form (S-OMA1) by itself upon mitochondrial membrane depolarization; S-OMA1 is degraded quickly but could be stabilized by CCCP treatment or Prohibitin (Montrer PHB Protéines) knockdown in cells.

  5. These findings demonstrate that (a) p53 (Montrer TP53 Protéines) and Oma1 mediate L-Opa1 (Montrer OPA1 Protéines) processing, (b) mitochondrial fragmentation is involved in CDDP-induced apoptosis in OVCA and CECA cells, and (c) dysregulated mitochondrial dynamics

  6. OMA1 controls OPA1 (Montrer OPA1 Protéines) cleavage and function.

  7. These results provide evidence for different substrate specificities of m-AAA (Montrer APP Protéines) proteases composed of different subunits and reveal a striking evolutionary switch of proteases involved in the proteolytic processing of dynamin (Montrer DNM1 Protéines)-like GTPases in mitochondria.

Mouse (Murine) OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) (OMA1) interaction partners

  1. The m-AAA (Montrer AAAS Protéines) protease associated with neurodegeneration limits MCU (Montrer MCU Protéines) activity in mitochondria.

  2. stress-induced OMA1 activation and guanosine triphosphatase OPA1 cleavage limit mitochondrial fusion and promote neuronal death

  3. The IMQC protease Oma1 is required for the stability of the respiratory supercomplexes and thus balanced and tunable bioenergetic function.

  4. OMA1-mediated OPA1 proteolysis plays an important role in the disruption of mitochondrial dynamics in ischemic acute kidney injury.

  5. Constitutive OPA1 cleavage by YME1L (Montrer YME1L1 Protéines) and OMA1 at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion.

  6. Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics.

  7. This study shows that OMA1 plays an essential role in the proteolytic inactivation of the dynamin (Montrer DNM1 Protéines)-related GTPase (Montrer RACGAP1 Protéines) OPA1 and describes its unexpected role in energy metabolism

  8. OMA1 regulates OPA1 cleavage in the mitochondrial inner membrane.

Profil protéine OMA1

Profil protéine

Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity).

Gene names and symbols associated with OMA1

  • OMA1 zinc metallopeptidase (OMA1)
  • OMA1 zinc metallopeptidase (Oma1)
  • si:ch73-215a11.1 (si:ch73-215a11.1)
  • 2010001O09Rik Protéine
  • DAB1 Protéine
  • MPRP-1 Protéine
  • oma1 Protéine
  • peptidase Protéine
  • RGD1304821 Protéine
  • YKR087C Protéine
  • ZMPOMA1 Protéine

Protein level used designations for OMA1

OMA1 homolog, zinc metallopeptidase , OMA1 zinc metallopeptidase homolog , metalloendopeptidase OMA1, mitochondrial , metalloprotease related protein 1 , metalloprotease-related protein 1 , overlapping activity with M-AAA protease , overlapping with the m-AAA protease 1 homolog , zinc metallopeptidase OMA1 , Metalloendopeptidase OMA1, mitochondrial , OMA1 zinc metallopeptidase , Overlapping with the m-AAA protease 1 homolog , Metalloendopeptidase OMA1, mitochondrial-like protein , metalloendopeptidase OMA1 mitochondrial-like protein

GENE ID SPECIES
115209 Homo sapiens
298282 Rattus norvegicus
67013 Mus musculus
506223 Bos taurus
100730704 Cavia porcellus
100331186 Danio rerio
100338330 Oryctolagus cuniculus
489569 Canis lupus familiaris
100067642 Equus caballus
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