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OTUD5 encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily.
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Human Polyclonal OTUD5 Primary Antibody pour ELISA - ABIN451675
Kayagaki, Phung, Chan, Chaudhari, Quan, ORourke, Eby, Pietras, Cheng, Bazan, Zhang, Arnott, Dixit: DUBA: a deubiquitinase that regulates type I interferon production. dans Science (New York, N.Y.) 2007
Findings have uncovered an apoptotic signaling cascade linking PDCD5 (Montrer PDCD5 Anticorps), OTUD5, and p53 (Montrer TP53 Anticorps) during genotoxic stress responses.
OTUD5 is required for the stabilization and the activation of a p53 (Montrer TP53 Anticorps) response
Here the authors show that phosphorylation of the human deubiquitinase DUBA (OTUD5) at a single residue, Ser177, is both necessary and sufficient to activate the enzyme.
data identify DUBA as a negative regulator of innate immune responses
data identify DUBA as a cell-intrinsic suppressor of IL-17 (Montrer IL17A Anticorps) production
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.
OTU domain containing 5
, OTU domain-containing protein 5
, OTU domain-containing protein 5-A
, deubiquitinating enzyme A
, deubiquinating enzyme A