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OLFM1 product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein.
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OLFM1 is a negative regulator of non-canonical NF-kappaB (Montrer NFKB1 Kits ELISA) signalling by interacting with and inhibiting NIK. Thus, OLFM1 may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC (Montrer CALR Kits ELISA)) patients.
human chorionic gonadotropin stimulated miR (Montrer MLXIP Kits ELISA)-212, which down-regulated OLFM1 and CTBP1 (Montrer CTBP1 Kits ELISA) expression in fallopian and endometrial epithelial cells to favor spheroid attachment
OLF domains from H. sapiens olfactomedin-1 and M. musculus gliomedin (Montrer GLDN Kits ELISA) were biophysically, biochemically, and structurally characterized.
Down-regulation of OLFM1 in fallopian tube epithelial cells enhances spheroid attachment to fallopian tube.
Wnt (Montrer WNT2 Kits ELISA) activation suppresses Olfm-1 expression, and this may predispose a favorable microenvironment of the retained embryo in the Fallopian tube, leading to ectopic pregnancy in humans
The OLFM1 is a newly identified interphotoreceptor matrix (IPM) molecule that serves an important role for photoreceptor homeostasis, which is significantly compromised in the eyes of Olfm1 mutant mice.
Defective fertility in Olfm1(-/-) females is most likely a secondary effect of defective olfaction.
Olfm1 is a multifunctional protein that may play important roles not only in differentiation and proliferation of neuronal precursor cells and axon growth but also in behavior, olfactory activity and numerous functions associated with Ca2 (Montrer CA2 Kits ELISA) + signaling
study of noelin expression during mouse development
This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.
, neuroblastoma protein
, neuronal olfactomedin-related ER localized protein
, olfactomedin related ER localized protein
, pancortin 1
, Noelin 1
, Noelin 2
, Pancortin 1-4