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OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). De plus, nous expédions Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Anticorps (41) et Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Kits (8) et beaucoup plus de produits pour cette protéine.
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CTC1-STN1 terminates TERT while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells.
CTC1/STN1/TEN1 (CST) deficiency diminishes HU-induced RAD51 foci formation.
STN1-POLA2 interaction provides a basis for primase-polymerase alpha stimulation by human STN1. A disease-causing mutation in human STN1 engenders a selective defect in POLA2-binding.
The findings imply that theCTC1/STN1/TEN1 complex(CST )complex plays an important role in regulating telomere maintenance in alternative-lengthening of telomeres(ALT) cells.
TERT-mediated G-strand extension and Ctc1-Stn1-Ten1-mediated C-strand fill-in are equally important for telomere length maintenance.
Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.
The mammalian CST (CTC1-STN1-TEN1) complex is directly involved at several stages of telomere end formation and CST seems to play critical roles in coordinating telomerase elongation and fill-in synthesis to telomere replication.
we explored two SNPs in genes associated either with telomere biology (OBFC1) or with LTL (OBCF1 and CTC1). Interestingly, we observed that genetic variation does not account for LTL at birth
A 2-SNP OBFC1 haplotype was associated with higher risk of CHD, and a 3-SNP TERC haplotype was associated with both higher risk of CHD and T2D.
The Stn1 deficiency leads to persistent and elevated association of DNA polymerase alpha to telomeres, suggesting that Stn1 may modulate the DNA synthesis activity of polalpha rather than controlling the loading of polalpha to telomeres.
the requirement for STN1/CST in telomere duplex replication correlates with increasing telomere length and replication stress.
CTC1-STN1-TEN1 complex rescues stalled replication forks during conditions of replication stress, such as those found at natural replication barriers, likely by facilitating dormant origin firing
the human CST (CTC1, STN1 and TEN1) complex, previously implicated in telomere protection and DNA metabolism, inhibits telomerase activity through primer sequestration and physical interaction with the protection of telomeres 1 (POT1)-TPP1 telomerase processivity factor
Ctc1-Stn1-Ten1 is a replication protein A (RPA)-like complex that is not directly involved in conventional DNA replication at forks but plays a role in DNA metabolism frequently required by telomeres.
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology.
OBFC1 is identical to the previously described 44 kDa subunit of DNA-pol-alpha/primase associated factor (AAF) which increases polymerase-alpha/primase template affinity and stimulate both DNA primase and polymerase-alpha activities in vitro.
STN1 plays a genome-wide role in DNA replication and telomere stability.
POT1a promotes an extendable telomere state via contacts with the telomerase RNP as well as STN1 and CTC1, while TEN1 opposes these functions.
findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis
AtSTN1 is a crucial component of the protective telomere cap in Arabidopsis, and likely in other multicellular eukaryotes. (AtSTN1)
CTC1 participates in telomere maintenance in diverse species and that a CST-like complex is required for telomere integrity in multicellular organisms.
OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009
CST complex subunit STN1
, alpha accessory factor 44
, oligonucleotide/oligosaccharide-binding fold-containing protein 1
, replication protein A 32 kDa subunit
, suppressor of cdc thirteen homolog
, alpha-accessory factor of 44 kDa