Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Protéines (OBFC1)

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). De plus, nous expédions Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Anticorps (43) et Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Kits (8) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
OBFC1 79991 Q9H668
OBFC1 108689 Q8K2X3
Rat OBFC1 OBFC1 294025 Q6AYD2
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Showing 10 out of 13 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Escherichia coli (E. coli) Humain His tag   50 μg Connectez-vous pour afficher 4 Days
$522.50
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Escherichia coli (E. coli) Humain His tag 50 μg Connectez-vous pour afficher 15 to 19 Days
$492.31
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$547.80
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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Levure Arabidopsis thaliana His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,361.33
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Levure REACT_Bullfrog His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,907.67
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Levure REACT_Panda His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,004.83
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Levure Cynomolgus His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,008.50
Détails

OBFC1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, ,
Mouse (Murine)

Plus protéines pour Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) partenaires d'interaction

Human Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) interaction partners

  1. CTC1/STN1 (Montrer STON1 Protéines)/TEN1 (Montrer TEN1 Protéines) (CST (Montrer GAL3ST1 Protéines)) deficiency diminishes HU-induced RAD51 (Montrer RAD51 Protéines) foci formation.

  2. STN1 (Montrer STON1 Protéines)-POLA2 (Montrer POLA2 Protéines) interaction provides a basis for primase-polymerase alpha stimulation by human STN1 (Montrer STON1 Protéines). A disease-causing mutation in human STN1 (Montrer STON1 Protéines) engenders a selective defect in POLA2 (Montrer POLA2 Protéines)-binding.

  3. The findings imply that theCTC1/STN1/TEN1 complex(CST )complex plays an important role in regulating telomere maintenance in alternative-lengthening of telomeres(ALT) cells.

  4. TERT (Montrer TERT Protéines)-mediated G-strand extension and Ctc1-Stn1 (Montrer STON1 Protéines)-Ten1 (Montrer TEN1 Protéines)-mediated C-strand fill-in are equally important for telomere length maintenance.

  5. Mutations in STN1 (Montrer STON1 Protéines) cause Coats plus syndrome and are associated with genomic and telomere defects.

  6. The mammalian CST (Montrer GAL3ST1 Protéines) (CTC1-STN1 (Montrer STON1 Protéines)-TEN1 (Montrer TEN1 Protéines)) complex is directly involved at several stages of telomere end formation and CST (Montrer GAL3ST1 Protéines) seems to play critical roles in coordinating telomerase elongation and fill-in synthesis to telomere replication.

  7. we explored two SNPs in genes associated either with telomere biology (OBFC1) or with LTL (OBCF1 and CTC1). Interestingly, we observed that genetic variation does not account for LTL at birth

  8. A 2-SNP OBFC1 haplotype was associated with higher risk of CHD (Montrer CHDH Protéines), and a 3-SNP TERC haplotype was associated with both higher risk of CHD (Montrer CHDH Protéines) and T2D.

  9. The Stn1 deficiency leads to persistent and elevated association of DNA polymerase alpha to telomeres, suggesting that Stn1 may modulate the DNA synthesis activity of polalpha rather than controlling the loading of polalpha to telomeres.

  10. the requirement for STN1 (Montrer STON1 Protéines)/CST (Montrer GAL3ST1 Protéines) in telomere duplex replication correlates with increasing telomere length and replication stress.

Mouse (Murine) Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) interaction partners

  1. OBFC1 is identical to the previously described 44 kDa subunit of DNA-pol-alpha/primase associated factor (AAF) which increases polymerase-alpha/primase template affinity and stimulate both DNA primase and polymerase-alpha activities in vitro.

Arabidopsis thaliana Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) interaction partners

  1. STN1 plays a genome-wide role in DNA replication and telomere stability.

  2. POT1a (Montrer POT1 Protéines) promotes an extendable telomere state via contacts with the telomerase RNP (Montrer RNPC3 Protéines) as well as STN1 and CTC1, while TEN1 (Montrer TEN1 Protéines) opposes these functions.

  3. findings indicate that ATR and CST (Montrer GAL3ST1 Protéines) (CTC1/STN1/TEN1 (Montrer TEN1 Protéines)) act synergistically to maintain genome integrity and telomere length homeostasis

  4. AtSTN1 is a crucial component of the protective telomere cap in Arabidopsis, and likely in other multicellular eukaryotes. (AtSTN1)

  5. CTC1 participates in telomere maintenance in diverse species and that a CST (Montrer GAL3ST1 Protéines)-like complex is required for telomere integrity in multicellular organisms.

Profil protéine Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1)

Profil protéine

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009

Gene names and symbols associated with OBFC1

  • STN1, CST complex subunit (STN1)
  • STN1, CST complex subunit (Stn1)
  • STN1, CST complex subunit (stn1)
  • Nucleic acid-binding, OB-fold-like protein (STN1)
  • 0610009H20Rik Protéine
  • 2310057J23Rik Protéine
  • AAF-44 Protéine
  • AAF44 Protéine
  • AI413458 Protéine
  • ATSTN1 Protéine
  • bA541N10.2 Protéine
  • F10K1.17 Protéine
  • F10K1_17 Protéine
  • RP11-541N10.2 Protéine
  • RPA-32 Protéine
  • STN1 Protéine
  • zgc:64174 Protéine

Protein level used designations for OBFC1

CST complex subunit STN1 , alpha accessory factor 44 , oligonucleotide/oligosaccharide-binding fold-containing protein 1 , replication protein A 32 kDa subunit , suppressor of cdc thirteen homolog , alpha-accessory factor of 44 kDa

GENE ID SPECIES
79991 Homo sapiens
108689 Mus musculus
294025 Rattus norvegicus
514213 Bos taurus
393360 Danio rerio
837223 Arabidopsis thaliana
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