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The protein encoded by OPRL1 is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin.
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Bat Polyclonal OPRL1 Primary Antibody pour WB - ABIN611203
Nishimoto, Fukushima, Okuda, Muramatsu: The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. dans Molecular and cellular biology 1999
Show all 5 Pubmed References
The rs2229205 SNP in the OPRL1 gene may be a genetic factor that contributes to individual differences in the vulnerability to smoking in Japanese individuals
The results of in vitro Ala scanning analyses revealed that the labeled residues were Cys59 in TM1 (Montrer TPM2 Anticorps), Cys215 and Cys231 in TM5, and Cys310 in TM7. The present study has provided a novel method of Cys (Montrer DNAJC5 Anticorps)(Npys)-affinity labeling for identification of the ligand-binding sites in the ORL1 receptor.
Study presents evidence suggesting that the PNOC (Montrer PNOC Anticorps) and OPRL1 are dysregulated in suicide completers, thereby potentially contributing to impaired emotional and behavioral control and, ultimately, to the suicidal crisis
Data suggest that nociceptin (Montrer PNOC Anticorps) and nociceptin receptor evolved as one of 4 opioid receptor systems in vertebrates; this system exhibits both analgesic and hyperalgesic effects. [REVIEW]
Opioid neuropeptide systems are important mediators of ovarian steroid signaling that regulate reproduction in female; data suggest that nociceptin (Montrer PNOC Anticorps) and nociceptin receptor system in arcuate nucleus of hypothalamus is such a system. [REVIEW]
Data suggest that the nociceptin/nociceptin (Montrer PNOC Anticorps) receptor system is involved in modulation of the immune response and in pathogenesis of autoimmune diseases. [REVIEW]
Data suggest that the nociceptin/nociceptin (Montrer PNOC Anticorps) receptor system is involved in modulation of psychological and inflammatory stress responses and in pathogenesis of anxiety. [REVIEW]
Data suggest that interaction between the nociceptin/nociceptin (Montrer PNOC Anticorps) receptor system and the orexin/orexin (Montrer OX Anticorps) receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW]
Data suggest that nociceptin/nociceptin (Montrer PNOC Anticorps) receptor signaling in neurons of the hippocampus modulate learning and memory. [REVIEW]
Overall methylation levels in the promoter regions of three genes (ALDH1A1 (Montrer ALDH1A1 Anticorps), OPRL1 and RGS19 (Montrer RGS19 Anticorps)) are elevated in subjects who were exposed to childhood adversity.
nociceptin (Montrer PNOC Anticorps) opioid receptor agonists are promising drugs for treating pain in sickle cell anemia.
These knock-in mice have NOP receptors that function both in vitro and in vivo and have provided a detailed characterization of NOP receptors in brain, spinal cord, and DRG neurons.
Oprl1 is associated with amygdala function, fear processing, and posttraumatic stress disorder symptoms.
the present results suggest that the endogenous OFQ/N (Montrer PNOC Anticorps)/NOP (Montrer CRYGB Anticorps) receptor system may modulate the development of cocaine-induced locomotor sensitization.
Data suggest that NOPR and MOPR (mu-type opioid receptor (Montrer OPRM1 Anticorps)) in spinal cord independently drive antinociception; NOPR/MOPR (Montrer OPRM1 Anticorps) ligands attenuate neuropathic/inflammatory pain and have high antinociceptive potency with low tolerance development.
Data suggest that nociceptin receptor/nociceptin (Montrer PNOC Anticorps) signaling plays a role in the disease pathogenesis of inflammatory bowel diseases.
The results of this study demonstrated the contribution of the NOP (Montrer CRYGB Anticorps) receptor in controlling food intake and meal pattern, as well as glutamate (Montrer GRIN1 Anticorps) release and GIRK1 (Montrer KCNJ3 Anticorps) channel activity at POMC (Montrer POMC Anticorps) synapses.
N/OFQ (Montrer PNOC Anticorps) and NOP (Montrer CRYGB Anticorps) receptors have an important role in hippocampus-dependent spatial learning and memory, probably by modulation of glutamatergic functions
These results suggest differential requirements for ORL(1) in the mediation of neuroimmune effects exerted at different times after an immune challenge.
OPR (Montrer ZIC5 Anticorps) is not crucial for development of either acute or neuropathic nociceptive responses, or for the regulation of full receptor-mediated responses to opioid agonists
The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding the same protein have been found for this gene.
opiate receptor-like 1
, opioid receptor XOR1
, kappa-type 3 opioid receptor
, kappa3-related opioid receptor
, nociceptin receptor
, orphanin FQ receptor
, nociceptin receptor ORL1
, opioid receptor-like 1
, orphanin FQ receptor-a
, orphanin FQ receptor-b
, orphanin FQ receptor-e
, peptide receptor
, seven transmembrane G protein-coupled receptor
, K3 opiate receptor
, orphanin FQ/nociceptin receptor
, N/OFQ receptor
, nociceptin/ orphaninFQ receptor
, opioid-receptor-like protein