Organic Solute Transporter alpha Protéines (OSTALPHA)

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. De plus, nous expédions Organic Solute Transporter alpha Anticorps (26) et Organic Solute Transporter alpha Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat OSTALPHA OSTALPHA 303879  
OSTALPHA 200931 Q86UW1
OSTALPHA 106407 Q8R000
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
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Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,493.38
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Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
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OSTALPHA Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Organic Solute Transporter alpha (OSTALPHA) partenaires d'interaction

Human Organic Solute Transporter alpha (OSTALPHA) interaction partners

  1. SLC51A expression is significantly upregulated in human masticatory mucosa during wound healing

  2. Hepatic OSTalpha-OSTbeta expression is induced by hypoxia.

  3. Ostbeta is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes.

  4. The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta in different tissues.

  5. OSTalpha has roles in biological transport and is widely expressed in human tissues

  6. overexpression of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate and the activation of FXR target genes

  7. OSTalpha/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST genes by the nuclear bile acid receptor/farnesoid X receptor (FXR).

  8. the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.

  9. These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor.

  10. Demonstrate association of OST-alpha and OST-beta to determine trafficking to plasma membrane and activity.

  11. The mRNA expression of OSTalpha-OSTbeta was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta: 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers

  12. human OSTalpha is a glycoprotein that requires interaction with OSTbeta to reach the plasma membrane. However, glycosylation of OSTalpha is not necessary for interaction with the beta subunit or for membrane localization .

Mouse (Murine) Organic Solute Transporter alpha (OSTALPHA) interaction partners

  1. Data suggest that transport of bile acid taurocholate is retained when OstB (organic solute transporter beta subunit) is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA; shorter fragments of OstB are inactive.

  2. These findings indicate that loss of OSTalpha protects against age-related weight gain and insulin resistance.

  3. Ileal FGF15 expression was directly correlated with plasma cholesterol levels and aortic cholesterol content. In contrast, plasma and hepatic cholesterol levels and atherosclerosis development were not reduced in apoE(-/-) mice deficient in Ostalpha.

  4. Total ileal FGF15 expression was elevated almost 20-fold in Ostalpha(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression

  5. Inactivation of FXR largely unmasked the bile acid malabsorption phenotype and corrected the bile acid homeostasis defect in Ostalpha null mice.

  6. Ostalpha-deficient mice efficiently eliminate excess bile acids via the feces.

  7. OSTalpha is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS homeostasis

  8. These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine.

  9. Co-expression of mouse Ostalpha-Ostbeta, but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate

  10. OSTalpha and OSTbeta mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR-/-, mice

  11. the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.

  12. In conclusion, we identified Ost-alpha/Ost-beta as a novel FXR target. Absent Ost-alpha/Ost-beta induction in CA-fed FXR(-/-) animals may contribute to increased liver injury in these animals.

  13. The mouse Ostalpha and Ostbeta promoters are unusual in that they contain functional FXR and LRH elements, which mediate, respectively, positive and negative feedback regulation by bile acids.

  14. These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor.

  15. LXRalpha transcriptionally regulate mouse organic solute transporter alpha/beta via inverted repeat-1 elements shared with farnesoid X receptor

  16. Present as heterodimers (with Ost beta) and/or heteromultimers; the interaction between Ostalpha and Ostbeta increases the stability of the proteins and is required for delivery of the heteromeric complex to the plasma membrane.

  17. These data indicate that Ostalpha-Ostbeta is essential for intestinal bile acid transport in mice.

  18. These findings provide direct support for the hypothesis that Ostalpha-Ostbeta is a major basolateral transporter of bile acids and conjugated steroids in the intestine, kidney, and liver.

Profil protéine Organic Solute Transporter alpha (OSTALPHA)

Profil protéine

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).

Gene names and symbols associated with OSTALPHA

  • solute carrier family 51, alpha subunit (Slc51a)
  • solute carrier family 51 alpha subunit (SLC51A)
  • AV001382 Protéine
  • AW261577 Protéine
  • D630035O19Rik Protéine
  • OSTA Protéine
  • OSTALPHA Protéine
  • RGD1311100 Protéine

Protein level used designations for OSTALPHA

organic solute transporter alpha , organic solute transporter subunit alpha , OST-alpha , organic solute transporter, alpha subunit , solute carrier family 51 subunit alpha

GENE ID SPECIES
303879 Rattus norvegicus
200931 Homo sapiens
106407 Mus musculus
516626 Bos taurus
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