Oxysterol Binding Protein 2 Protéines (OSBP2)

Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. De plus, nous expédions OSBP2 Anticorps (39) et OSBP2 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
OSBP2 23762 Q969R2
OSBP2 74309 Q5QNQ6
Rat OSBP2 OSBP2 305475  
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Top OSBP2 Protéines sur anticorps-enligne.fr

Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$932.80
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails

OSBP2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Oxysterol Binding Protein 2 (OSBP2) partenaires d'interaction

Human Oxysterol Binding Protein 2 (OSBP2) interaction partners

  1. This study reveals detailed mechanistic insight into the role of ORP4L in PLCbeta3 redistribution from storage within the nucleus to the plasma membrane via RAN activation and interaction with VAPA in Jurkat T-cells.

  2. The authors uncovered a signalling pathway operating specifically in T-cell acute lymphoblastic leukemia cells in which ORP4L mediates G protein-coupled ligand-induced PLCbeta3 activation, resulting in an increase of mitochondrial respiration for cell survival.

  3. High ORP4L expression is associated with cervical carcinoma.

  4. ORP4L is crucial for macrophage survival and plays a role in the development of atherosclerosis.

  5. ORP4 promotes the survival of rapidly proliferating cells.

  6. Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation.

  7. In preliminary results, significantly higher levels of OSBP2 and OSBPL-7 mRNA were seen in blood samples from cholangiocarcinoma patients than in healthy controls.

  8. OSBP2 has a role in chronic myeloid leukemia

  9. Thus the sterol-binding domain of ORP4 binds vimentin, cholesterol and oxysterols, and interacts with the filamentous vimentin network.

  10. a possible role of OSBP2 gene in the pathogenesis of oxidative damage to the macula induced by oxysterols in age-related macular degeneration patients.

Mouse (Murine) Oxysterol Binding Protein 2 (OSBP2) interaction partners

  1. ORP4 is essential for the postmeiotic differentiation of germ cells

Profil protéine OSBP2

Profil protéine

Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.

Gene names and symbols associated with OSBP2

  • oxysterol binding protein 2 (OSBP2)
  • oxysterol binding protein 2 (Osbp2)
  • 1700095P05Rik Protéine
  • C630001G20Rik Protéine
  • Gm244 Protéine
  • ORP-4 Protéine
  • ORP4 Protéine
  • OSBPL1 Protéine
  • OSBPL4 Protéine
  • RGD1309479 Protéine

Protein level used designations for OSBP2

oxysterol-binding protein 2 , OSBP-related protein 4 , oxysterol binding protein-like 1 , oxysterol binding protein-related protein 4 , oxysterol-binding protein-related protein 4

GENE ID SPECIES
510311 Bos taurus
23762 Homo sapiens
74309 Mus musculus
305475 Rattus norvegicus
417002 Gallus gallus
477541 Canis lupus familiaris
100157528 Sus scrofa
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