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OSBPL1A encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. De plus, nous expédions Oxysterol Binding Protein-Like 1A Protéines (5) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal OSBPL1A Primary Antibody pour ELISA, IHC (p) - ABIN250060
Lehto, Laitinen, Chinetti, Johansson, Ehnholm, Staels, Ikonen, Olkkonen: The OSBP-related protein family in humans. dans Journal of lipid research 2001
Show all 3 Pubmed References
a familial loss-of-function mutation in OSBPL1A affects the first step of the reverse cholesterol transport process and associates with a low HDL (Montrer HSD11B1 Anticorps)-C phenotype
ORP1L-VAP (Montrer F10 Anticorps) complexes also support transport of LDL-derived cholesterol from endosomes to the endoplasmic reticulum when ORP1L was bound to human adenovirus RIDalpha. RIDalpha-induced lipid trafficking also attenuated proinflammatory signaling by Toll-like receptor 4 (Montrer TLR4 Anticorps), which has a central role in adenovirus pathogenesis and is known to be tightly regulated by cholesterol-rich "lipid rafts."
ORP1S is a cytoplasmic sterol sensor, which transports sterols to the nucleus and promotes LXR (Montrer NR1H3 Anticorps) regulated trans-activation of apoE (Montrer APOE Anticorps).
The study shows that OSBPL1A binds several oxysterols and cholesterol, and characterize a mutant, OSBPL1A Delta560-563, defective in oxysterol bi (Montrer APOA1 Anticorps)nding.
Results suggest that the two forms of oxysterol binding protein-related protein-1 (ORP1) are functionally distinct and that ORP1L is involved in control of cellular lipid metabolism
binds to Rab7 (Montrer RAB7B Anticorps), modifies its functional cycle, and can interfere with lysosome organization and endocytic membrane trafficking.
OSBPL1A was preferentially expressed from the maternal allele
Results describe how ORP1L contacts VAP (Montrer F10 Anticorps) to control Rab7 (Montrer RAB7B Anticorps)-RILP (Montrer RILP Anticorps)-p150 Glued (Montrer DCTN1 Anticorps) and late endosome positioning.
Osbpl1a silencing in macrophage foam cells enhances endosome motility and results in inhibition of [(3)H]cholesterol efflux to apolipoprotein A-I (Montrer APOA1 Anticorps).
OSBP (Montrer OSBP Anticorps) regulates hepatic TG metabolism and suggest the involvement of OSBP (Montrer OSBP Anticorps) in the insulin (Montrer INS Anticorps) signaling pathways that control hepatic lipogenesis.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist\; they encode different isoforms.
OSBP-related protein 1
, oxysterol binding protein-like 1B
, oxysterol-binding protein-related protein 1
, oxysterol-binding protein-related protein 1 variant 1
, oxysterol-binding protein-related protein 1 variant 2
, oxysterol-binding protein-like 1A
, oxysterol binding protein-like 1A
, oxysterol binding protein-like protein 1A
, oxysterol-binding protein-related protein 1-like