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OSBPL6 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. De plus, nous expédions Oxysterol Binding Protein-Like 6 Protéines (6) et beaucoup plus de produits pour cette protéine.
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family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG (Montrer PTPRG Anticorps), OSBPL6, and PDCL3 (Montrer PDCL3 Anticorps) that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG (Montrer PTPRG Anticorps), rs1347297 in the gene OSBPL6, and rs1513625 near PDCL3 (Montrer PDCL3 Anticorps). In addition, rs72953347 in OSBPL6 and two SNPs in the gene CDKAL1 (Montrer CDKAL1 Anticorps) showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).
Oxysterol-binding protein-like 6 is a novel regulator of cholesterol trafficking that is part of the miR (Montrer MLXIP Anticorps)-33 and miR (Montrer MLXIP Anticorps)-27b target gene networks contributing to the maintenance of cholesterol homeostasis.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.
, OSBP-related protein 6
, oxysterol-binding protein-related protein 6