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The protein encoded by PDS5A binds to the cohesin complex and associates with chromatin through most of the cell cycle. De plus, nous expédions PDS5A Anticorps (63) et et beaucoup plus de produits pour cette protéine.
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The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL.
These results provide the first evidence indicating a tumor suppressor role of SA1 in early colon carcinogenesis
By interacting with a unique domain of Esco1, Pds5 recruits Esco1 to chromatin-bound cohesin complexes to form cohesion.
The data show a downregulation of proliferation-associated host gene PDS5A and suggest a role of PDS5A in HIV-1-induced cellular pathogenesis but not viral replication.
Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells.
Findings suggest that the SCC-112 gene expression is likely to be associated with normal cell growth and proliferation.
SCC-112 improve cell proliferation and contributes to tumorigenesis by interacting with p63 and promoting cell cycling.
While Pds5A(-/-) and Pds5B(-/-) mice die at birth, embryos harboring 3 mutant Pds5 alleles die between E11.5 and E12.5 most likely of heart failure, indicating that total Pds5 gene dosage is critical for normal development.
The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene.
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
, SCC-112 protein
, sister chromatid cohesion protein PDS5 homolog A-A
, sister chromatid cohesion protein PDS5 homolog A-B
, sister chromatid cohesion protein Pds5A
, cell proliferation-inducing gene 54 protein
, sister chromatid cohesion protein 112
, sister chromatid cohesion protein PDS5 homolog A