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PDZK1 encodes a PDZ domain-containing scaffolding protein. De plus, nous expédions PDZK1 Kits (7) et PDZK1 Protéines (7) et beaucoup plus de produits pour cette protéine.
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Cow (Bovine) Polyclonal PDZK1 Primary Antibody pour ICC, IF - ABIN152917
Lan, Silver: Fenofibrate induces a novel degradation pathway for scavenger receptor B-I independent of PDZK1. dans The Journal of biological chemistry 2005
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Human Monoclonal PDZK1 Primary Antibody pour IHC (p), ELISA - ABIN562170
Walker, MacLeod, Williams, Cameron, Smyth, Langdon: Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer. dans Gynecologic oncology 2007
PDZK1 directly interacts with OATP2B1 (Montrer SLCO2B1 Anticorps) resulting in a change of the amount of transporter in the membrane, and thereby in an increased transport function.
These findings have provided first lines of evidences that PDZK1 expression is negatively correlated with SHP-1 activation and poor clinical outcomes in clear cell renal cell carcinoma (ccRCC) . PDZK1 was identified as a novel tumor suppressor in ccRCC by negating SHP-1 activity
HNF1alpha (Montrer HNF1A Anticorps), which has previously been described as a modulator of several transporters of the renal transportosome, is also a key determinant of PDZK1 transcription.
a PDZK1 single nucleotide polymorphism rs12129861 was found to be significantly associated with gout susceptibility (meta-analysis)
PDZK1 was defined as an independent prognostic factor for both OS and DFS (Montrer FST Anticorps). These findings indicated that low level of PDZK1 could predict poor clinical outcome in patients with ccRCC.
Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 (Montrer SLC9A3 Anticorps) dysfunction observed in the inflamed intestine.
PARP (Montrer COL11A2 Anticorps) regulates estradiol-mediated cell growth by controlling the ER/IGF-1R (Montrer IGF1R Anticorps)/PDZK1 axis.
PDZK1, negatively regulates 5-HT2AR endocytosis and has no effect upon 5-HT2AR-mediated ERK1/2 phosphorylation.
Described is a structure of D-AKAP2 (Montrer AKAP10 Anticorps) in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta (Montrer SUCLA2 Anticorps)-strand to PDZK1.
PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability.
Dysfunction of intestinal OCTN1 (Montrer SLC22A4 Anticorps) in mouse model of chronic kidney disease (CKD) impaired the OCTN1 (Montrer SLC22A4 Anticorps)-ergothioneine axis, an adaptive antioxidant system, and that decreased antioxidant ergothioneine levels may contribute to CKD progression in a PDZK1-dependent manner.
These results suggest that the PDZ domain (Montrer INADL Anticorps) of PICK1 (Montrer PICK1 Anticorps) directly interacts with calcineurin B (Montrer CAN Anticorps) in osteoclast progenitor cells and promotes osteoclast differentiation through activation of calcineurin-NFAT (Montrer NFATC1 Anticorps) signaling.
PDZK1 has novel SR-BI (Montrer SCARB1 Anticorps)-independent function in VSM that affords protection from neointima formation, and this involves PDZK1 suppression of VSM cell proliferation via an inhibitory interaction with Bcr (Montrer BCR Anticorps)
Data show that interaction of the inducible nitric oxide synthase (iNOS (Montrer NOS2 Anticorps)) C-terminus with the PDZ (Montrer INADL Anticorps) domains of EBP50 (Montrer SLC9A3R1 Anticorps) protein or Pdzk1 protein CAP70 resulted greater nitric oxide (NO) synthesis.
PDZK1 regulates intracellular trafficking of Oatp1a1.
PDZK1(NHERF3) is entirely non-raft associated with lipid rafts in brush border membrane fractions of NHE3 (Montrer SLC9A3 Anticorps).
NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.
SR-BI (Montrer SCARB1 Anticorps) and PDZK1 protein and mRNA expression levels fell rapidly in primary hepatocyte cultures, indicating this system does not adequately mimic hepatocytes in vivo for analysis of the PDZK1 dependence of SR-BI (Montrer SCARB1 Anticorps).
the localization of PDZK1 on hepatocyte cell surface membranes in vivo is dependent on its PDZ4 domain and the presence of SR-BI (Montrer SCARB1 Anticorps).
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PDZ domain containing 1
, Na(+)/H(+) exchange regulatory cofactor NHE-RF3-like
, CFTR-associated protein of 70 kDa
, Na(+)/H(+) exchange regulatory cofactor NHE-RF3
, PDZ-containing kidney protein 1
, na/Pi cotransporter C-terminal-associated protein 1
, sodium-hydrogen exchanger regulatory factor 3
, Na(+)/H(+) exchanger regulatory factor 3
, PDZ domain-containing protein 1
, PDZK1-like protein
, C-terminal linking and modulating protein
, C-terminal-linking and modulating protein
, dietary Pi-regulated RNA-1