anti-PDZ Domain Containing 1 (PDZK1) Anticorps

PDZK1 encodes a PDZ domain-containing scaffolding protein. De plus, nous expédions PDZK1 Kits (7) et PDZK1 Protéines (7) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PDZK1 5174 Q5T2W1
PDZK1 59020 Q9JIL4
PDZK1 65144 Q9JJ40
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Top anti-PDZK1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 96 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-PDZK1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate PDZK1 is supported by BioGPS gene expression data to be expressed in HepG2 WB Suggested Anti-PDZK1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: HepG2 cell lysate  PDZK1 is supported by BioGPS gene expression data to be expressed in HepG2 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue reacted with PDZK1 Antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of PDZK1 Antibody (Center) in NCI-H292 cell line lysates (35ug/lane). This demonstrates the PDZK1 antibody detected the PDZK1 protein (arrow). 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$484.00
Détails
Chien Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Roussette (Chauve-souris) Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of A549 whole cell lysates, using PDZK1 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277517 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Souris Inconjugué ELISA, IHC, IHC (p), WB Anti-PDZK1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μL Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Souris Inconjugué ELISA, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-PDZK1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Connectez-vous pour afficher 11 to 14 Days
$561.00
Détails
Humain Lapin Inconjugué IHC, WB 100 μL Connectez-vous pour afficher 11 to 13 Days
$366.77
Détails
Humain Lapin Inconjugué IHC (p), WB Western Blot at 1:1000 dilution + MCF-7 whole cell lysate Lysates/proteins at 20 ug per lane. PDZK1 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$446.88
Détails

anti-PDZK1 Anticorps mieux référencés

  1. Cow (Bovine) Polyclonal PDZK1 Primary Antibody pour ICC, IF - ABIN152917 : Lan, Silver: Fenofibrate induces a novel degradation pathway for scavenger receptor B-I independent of PDZK1. dans The Journal of biological chemistry 2005 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal PDZK1 Primary Antibody pour IHC (p), ELISA - ABIN562170 : Walker, MacLeod, Williams, Cameron, Smyth, Langdon: Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer. dans Gynecologic oncology 2007 (PubMed)

Plus d’anticorps contre PDZK1 partenaires d’interaction

Human PDZ Domain Containing 1 (PDZK1) interaction partners

  1. Pdzk1 protein level was also reduced in the spermatozoa in case of asthenozoospermic patients compared with that in normozoospermic men, suggesting that Pdzk1 may participate in sperm maturation regulation and may be associated with male infertility.

  2. Our and other data predict that the urate-raising T allele of rs1967017 enhances HNF4A binding to the PDZK1 promoter, thereby increasing PDZK1 expression. As PDZK1 is a scaffold protein for many ion channel transporters, increased expression can be predicted to increase activity of urate transporters and alter excretion of urate.

  3. transactivation of the PDZK1-promoter by triiodothyronine mediated by thyroid hormone receptors (THR) alpha and beta.

  4. PDZK1 directly interacts with OATP2B1 resulting in a change of the amount of transporter in the membrane, and thereby in an increased transport function.

  5. These findings have provided first lines of evidences that PDZK1 expression is negatively correlated with SHP-1 activation and poor clinical outcomes in clear cell renal cell carcinoma (ccRCC) . PDZK1 was identified as a novel tumor suppressor in ccRCC by negating SHP-1 activity

  6. HNF1alpha, which has previously been described as a modulator of several transporters of the renal transportosome, is also a key determinant of PDZK1 transcription.

  7. a PDZK1 single nucleotide polymorphism rs12129861 was found to be significantly associated with gout susceptibility (meta-analysis)

  8. PDZK1 was defined as an independent prognostic factor for both OS and DFS. These findings indicated that low level of PDZK1 could predict poor clinical outcome in patients with ccRCC.

  9. Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 dysfunction observed in the inflamed intestine.

  10. PARP regulates estradiol-mediated cell growth by controlling the ER/IGF-1R/PDZK1 axis.

  11. PDZKA1 adaptor protein gene of urate transporters, is not associated with gout.

  12. PDZK1, negatively regulates 5-HT2AR endocytosis and has no effect upon 5-HT2AR-mediated ERK1/2 phosphorylation.

  13. Described is a structure of D-AKAP2 in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta-strand to PDZK1.

  14. PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability.

  15. Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37

  16. IRF3 activation by innate antiviral signaling represses TGF-beta-induced growth inhibition, gene regulation and epithelial-mesenchymal transition, and the generation of Treg effector lymphocytes from naive CD4(+) lymphocytes.

  17. NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.

  18. These results clarify the relationship between ER-alpha and PDZK1, propose a direct relationship between PDZK1 and IGF1R, and identify a novel oncogenic activity for PDZK1 in breast cancer.

  19. Antibody screening revealed 3 candidate prognostic markers in breast cancer: the Anillin (ANLN); PDZ-Binding Kinase (PBK); and, PDZ-Domain Containing 1 (PDZK1).

  20. Upregulation of PDZK1 could have an important role in the development of melasma in connection with estrogen through NHE, CFTR, and SLC26A3.

Mouse (Murine) PDZ Domain Containing 1 (PDZK1) interaction partners

  1. Pdzk1, which plays a critical role in cholesterol metabolism and carnitine transport, was found in sperm lipid metabolism. Western blotting and immunofluorescence analyses showed that Pdzk1 was expressed in the epididymis but not in the testis, and localized at the middle piece of the sperm tail.

  2. NHERF2 and NHERF3 have overlapping roles in NHE3 stimulation by LPA and inhibition by elevated Ca(2+) and cGMP.

  3. Dysfunction of intestinal OCTN1 in mouse model of chronic kidney disease (CKD) impaired the OCTN1-ergothioneine axis, an adaptive antioxidant system, and that decreased antioxidant ergothioneine levels may contribute to CKD progression in a PDZK1-dependent manner.

  4. These results suggest that the PDZ domain of PICK1 directly interacts with calcineurin B in osteoclast progenitor cells and promotes osteoclast differentiation through activation of calcineurin-NFAT signaling.

  5. Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 dysfunction observed in the inflamed intestine.

  6. PDZK1 has novel SR-BI-independent function in VSM that affords protection from neointima formation, and this involves PDZK1 suppression of VSM cell proliferation via an inhibitory interaction with Bcr

  7. Data show that interaction of the inducible nitric oxide synthase (iNOS) C-terminus with the PDZ domains of EBP50 protein or Pdzk1 protein CAP70 resulted greater nitric oxide (NO) synthesis.

  8. PDZK1 regulates intracellular trafficking of Oatp1a1.

  9. PDZK1(NHERF3) is entirely non-raft associated with lipid rafts in brush border membrane fractions of NHE3.

  10. NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.

  11. SR-BI and PDZK1 protein and mRNA expression levels fell rapidly in primary hepatocyte cultures, indicating this system does not adequately mimic hepatocytes in vivo for analysis of the PDZK1 dependence of SR-BI.

  12. the localization of PDZK1 on hepatocyte cell surface membranes in vivo is dependent on its PDZ4 domain and the presence of SR-BI.

  13. The impairment of the absorptive function of the inflamed colon in the IL-10(-/-) mouse, in spite of unaltered NHE3 expression and localization, is accompanied by the downregulation of the NHE3-regulatory PDZ adaptors NHERF2 and PDZK1.

  14. PDZK1 plays a pivotal role in the apical localization of BCRP.

  15. PDZK1-mediated control of hepatic SR-BI requires direct binding of the SR-BI C terminus to either the PDZ1 or PDZ3 domains, and that binding to both domains simultaneously is not required for PDZK1 control of hepatic SR-BI.

  16. The differential affinity of the Na/P(i) transporters for NHERF-1 and PDZK1 proteins could partially explain their differential regulation and/or stability in the apical membrane.

  17. PDZK1 appears to act as an adaptor for Oatp1a

  18. Although PDZK1 binding is required for optimal cell surface expression of oatp1a1, phosphorylation provides a mechanism for fast regulation of the distribution of oatp1a1 between the cell surface and intracellular vesicular pools.

  19. These findings demonstrate that deficiency of an adaptor protein essential for normal expression of a lipoprotein receptor promotes atherosclerosis in a murine model.

  20. there may be an additional site(s) within PDZK1 that bind(s) SR-BI and mediate(s) productive SR-BI-PDZK1 interaction previously attributed exclusively to the canonical binding of the C-terminal SR-BI to PDZ1.

PDZK1 profil antigène

Profil protéine

This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PDZK1

  • PDZ domain containing 1 (PDZK1) anticorps
  • PDZ domain containing 1 L homeolog (pdzk1.L) anticorps
  • PDZ domain containing 1 (pdzk1) anticorps
  • PDZ domain containing 1 (Pdzk1) anticorps
  • 1700023D20Rik anticorps
  • 2610507N21Rik anticorps
  • 4921513F16Rik anticorps
  • AI267131 anticorps
  • AI314638 anticorps
  • AL022680 anticorps
  • CAP70 anticorps
  • Clamp anticorps
  • D3Ertd537e anticorps
  • mPDZK1 anticorps
  • NHERF-3 anticorps
  • NHERF3 anticorps
  • Pdzd1 anticorps
  • PDZK1 anticorps
  • xpdzk1 anticorps

Protein level used designations for PDZK1

PDZ domain containing 1 , Na(+)/H(+) exchange regulatory cofactor NHE-RF3-like , CFTR-associated protein of 70 kDa , Na(+)/H(+) exchange regulatory cofactor NHE-RF3 , PDZ-containing kidney protein 1 , na/Pi cotransporter C-terminal-associated protein 1 , naPi-Cap1 , sodium-hydrogen exchanger regulatory factor 3 , NHERF-3 , Na(+)/H(+) exchanger regulatory factor 3 , PDZ domain-containing protein 1 , PDZK1-like protein , C-terminal linking and modulating protein , C-terminal-linking and modulating protein , dietary Pi-regulated RNA-1 , diphor-1

GENE ID SPECIES
418460 Gallus gallus
446272 Xenopus laevis
696698 Macaca mulatta
100065636 Equus caballus
100145801 Xenopus (Silurana) tropicalis
100152549 Sus scrofa
100403156 Callithrix jacchus
100482698 Ailuropoda melanoleuca
100012609 Monodelphis domestica
100588075 Nomascus leucogenys
100611671 Pan troglodytes
5174 Homo sapiens
59020 Mus musculus
475823 Canis lupus familiaris
534439 Bos taurus
100008900 Oryctolagus cuniculus
65144 Rattus norvegicus
100173285 Pongo abelii
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