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PHF6 is a member of the plant homeodomain (PHD)-like finger (PHF) family. De plus, nous expédions PHF6 Protéines (7) et PHF6 Kits (4) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 54 products:
Human Polyclonal PHF6 Primary Antibody pour ICC, IF - ABIN261177
Meacham, Lawton, Soto-Feliciano, Pritchard, Joughin, Ehrenberger, Fenouille, Zuber, Williams, Young, Hemann: A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. dans Genes & development 2015
Human Polyclonal PHF6 Primary Antibody pour ICC, IF - ABIN4345225
Pontén, Jirström, Uhlen: The Human Protein Atlas--a tool for pathology. dans The Journal of pathology 2008
EZH2 (Montrer EZH2 Anticorps) mutations coexisted with mutations of NOTCH1 (Montrer NOTCH1 Anticorps), IL7R (Montrer IL7R Anticorps), and PHF6 in the two Adult T-cell Acute Lymphoblastic Leukemia patients, and they responded poorly to chemotherapy and experienced difficult clinical histories and inferior outcomes
PHF6 mutations occur at a low frequency in pediatric acute myeloid leukemia (Montrer BCL11A Anticorps) in both female and male patients
PHF6 defects most likely result in their loss of function and have a substantial effect on the evolution into the aggressive types of myeloid neoplasms, associated with other concomitant genetic defects including RUNX1 (Montrer RUNX1 Anticorps) mutations
The mutations of the gene encoding plant homeodomain (PHD (Montrer PDC Anticorps))-like finger protein 6 (PHF6) contribute to the pathogenesis of the X-linked intellectual disability disorder Borjeson-Forssman-Lehmann syndrome.
PHF6 localizes to the sub-nucleolar fibrillar center where it binds to rDNA-coding sequences. PHF6 mediates the overall levels of ribosome biogenesis within a cell.
Our results suggest that PHF6 may function as an oncogenic factor in several types of cancer. We also hypothesize that PHF6 may also play its role in a tissue-specific manner. Our findings suggest further investigations regarding the exact role of PHF6 in tumor types.
Female phenotypes of Borjeson-Forssman-Lehmann syndrome patients with PHF6 mutations
Our RBBP4 (Montrer RBBP4 Anticorps)-PHF6 complex structure provides insights into the molecular basis of PHF6-NuRD complex interaction and implicates a role for PHF6 in chromatin structure modulation and gene regulation.
Phf6 is a "lineage-specific" cancer gene that plays opposing roles in developmentally distinct hematopoietic malignancies.
The PHF6 tumor suppressor gene was targeted in acute lymphoblastic leukemia by microRNA-128-3p.
active maintenance of a precise chromatin landscape is essential for sustaining proper leukemia cell identity and that loss of a single factor (PHF6) can cause focal changes in chromatin accessibility and nucleosome positioning that render cells susceptible to lineage transition
These results place miR (Montrer MLXIP Anticorps)-128 upstream of PHF6 in a pathway vital for cortical lamination as well as for the development of neuronal morphology and intrinsic excitability.
As part of a cell-intrinsic transcriptional pathway, PHF6 regulates neuronal migration in the brain.
Strongest Phf6 gene expression and nuclear localisation of Phf6 protein were observed in the developing central nervous system, the anterior pituitary gland, the primordia of facial structures and the limb buds.
This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms.
PHD finger protein 6
, PHD-like zinc finger protein
, centromere protein 31