anti-PHD Finger Protein 6 (PHF6) Anticorps

PHF6 is a member of the plant homeodomain (PHD)-like finger (PHF) family.

afficher tous les anticorps Gène GeneID UniProt
Anti-Humain PHF6 PHF6 84295 Q8IWS0
Anti-Souris PHF6 PHF6 70998 Q9D4J7
Anti-Rat PHF6 PHF6 100359714  
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Top anti-PHF6 Anticorps sur anticorps-enligne.fr

Showing 10 out of 51 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB WB Suggested Anti-PHF6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human brain 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-PHF6 Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$229.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-PHF6 Antibody Titration:  5.0ug/ml  Positive Control:  Jurkat cell lysate Sample Type: HEK293T cells transfected with a plasmid for over expression of myc-tagged PHF6Primary Dilution: 1:1000Secondary (goat anti-rabbit HRP) Dilution: 1:1000 100 μL Connectez-vous pour afficher 2 to 3 Days
$229.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: PHF6 Antibody [NBP1-88646] - Staining of human colon shows strong nuclear positivity in glandular cells. Immunocytochemistry/Immunofluorescence: PHF6 Antibody [NBP1-88646] - Staining of human cell line U-251MG shows positivity in nucleus & nucleoli. 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$491.63
Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: PHF6 Antibody [ABIN2611761] - Detection of Mouse PHF6 by Immunohistochemistry. Sample: FFPE section of mouse renal cell carcinoma. Antibody: Affinity purified rabbit anti-PHF6 used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$556.31
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), IP, WB Western Blot: PHF6 Antibody [ABIN2611772] - Image from a customer review testing on 293T cells. 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$556.31
Détails
Roussette (Chauve-souris) Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 7 to 9 Days
$493.17
Détails
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 7 to 9 Days
$493.17
Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), IP, IHC, WB Western Blot: PHF6 Antibody [ABIN2611750] - Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-PHF6 antibody ABIN2611750 used for WB at 0.04 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. PHF6 was also immunoprecipitated by rabbit anti-PHF6 antibodies ABIN2611751 and ABIN2611752, which recognize downstream epitopes. Detection: Chemiluminescence with exposure times of 10 seconds (A) and 3 seconds (B). 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$556.31
Détails
Humain Lapin Inconjugué WB Western Blot at 1:2000 dilution Lane 1: 293T/17 whole cell lysate Lane 2: A431 whole cell lysate Lane 3: Hela whole cell lysate Lane 4: Jurkat whole cell lysate Lane 5: K562 whole cell lysate Lysates/proteins at 20 ug per lane. 200 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails

anti-PHF6 Anticorps mieux référencés

  1. Human Polyclonal PHF6 Primary Antibody pour ICC, IF - ABIN261177 : Meacham, Lawton, Soto-Feliciano, Pritchard, Joughin, Ehrenberger, Fenouille, Zuber, Williams, Young, Hemann: A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. dans Genes & development 2015 (PubMed)

  2. Human Polyclonal PHF6 Primary Antibody pour ICC, IF - ABIN4345225 : Pontén, Jirström, Uhlen: The Human Protein Atlas--a tool for pathology. dans The Journal of pathology 2008 (PubMed)

Plus d’anticorps contre PHF6 partenaires d’interaction

Human PHD Finger Protein 6 (PHF6) interaction partners

  1. PHF6 mutations occur at a low frequency in pediatric acute myeloid leukemia (Montrer BCL11A Anticorps) in both female and male patients

  2. PHF6 defects most likely result in their loss of function and have a substantial effect on the evolution into the aggressive types of myeloid neoplasms, associated with other concomitant genetic defects including RUNX1 (Montrer RUNX1 Anticorps) mutations

  3. The mutations of the gene encoding plant homeodomain (PHD (Montrer PDC Anticorps))-like finger protein 6 (PHF6) contribute to the pathogenesis of the X-linked intellectual disability disorder Borjeson-Forssman-Lehmann syndrome.

  4. PHF6 localizes to the sub-nucleolar fibrillar center where it binds to rDNA-coding sequences. PHF6 mediates the overall levels of ribosome biogenesis within a cell.

  5. Our results suggest that PHF6 may function as an oncogenic factor in several types of cancer. We also hypothesize that PHF6 may also play its role in a tissue-specific manner. Our findings suggest further investigations regarding the exact role of PHF6 in tumor types.

  6. Female phenotypes of Borjeson-Forssman-Lehmann syndrome patients with PHF6 mutations

  7. Our RBBP4 (Montrer RBBP4 Anticorps)-PHF6 complex structure provides insights into the molecular basis of PHF6-NuRD complex interaction and implicates a role for PHF6 in chromatin structure modulation and gene regulation.

  8. Phf6 is a "lineage-specific" cancer gene that plays opposing roles in developmentally distinct hematopoietic malignancies.

  9. The PHF6 tumor suppressor gene was targeted in acute lymphoblastic leukemia by microRNA-128-3p.

  10. Our report confirms that PHF6 loss in females results in a recognizable phenotype overlapping with Coffin-Siris syndrome and distinct from Borjeson-Forssman-Lehmann syndrome.

Mouse (Murine) PHD Finger Protein 6 (PHF6) interaction partners

  1. active maintenance of a precise chromatin landscape is essential for sustaining proper leukemia cell identity and that loss of a single factor (PHF6) can cause focal changes in chromatin accessibility and nucleosome positioning that render cells susceptible to lineage transition

  2. These results place miR (Montrer MLXIP Anticorps)-128 upstream of PHF6 in a pathway vital for cortical lamination as well as for the development of neuronal morphology and intrinsic excitability.

  3. As part of a cell-intrinsic transcriptional pathway, PHF6 regulates neuronal migration in the brain.

  4. Strongest Phf6 gene expression and nuclear localisation of Phf6 protein were observed in the developing central nervous system, the anterior pituitary gland, the primordia of facial structures and the limb buds.

PHF6 profil antigène

Profil protéine

This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms.

Gene names and symbols associated with PHF6

  • PHD finger protein 6 (phf6) anticorps
  • PHD finger protein 6 L homeolog (phf6.L) anticorps
  • PHD finger protein 6 (PHF6) anticorps
  • PHD finger protein 6 (Phf6) anticorps
  • 2700007B13Rik anticorps
  • 4931428F02Rik anticorps
  • BFLS anticorps
  • BORJ anticorps
  • CENP-31 anticorps
  • mKIAA1823 anticorps
  • wu:fa22g03 anticorps
  • zgc:55403 anticorps

Protein level used designations for PHF6

PHD finger protein 6 , PHD-like zinc finger protein , centromere protein 31

GENE ID SPECIES
327070 Danio rerio
495066 Xenopus laevis
707390 Macaca mulatta
779543 Xenopus (Silurana) tropicalis
100151997 Sus scrofa
100225613 Taeniopygia guttata
100346149 Oryctolagus cuniculus
100379647 Monodelphis domestica
735789 Pan troglodytes
100054177 Equus caballus
84295 Homo sapiens
422235 Gallus gallus
612921 Canis lupus familiaris
518186 Bos taurus
70998 Mus musculus
100359714 Rattus norvegicus
100174671 Pongo abelii
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