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PITPNM3 encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. De plus, nous expédions PITPNM Family Member 3 Anticorps (36) et beaucoup plus de produits pour cette protéine.
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CCL18 can increase the invasive ability of non-small cell lung cancer cells by binding to its receptor Nir1.
CCL18 enhances hepatocellular carcinoma (HCC) cell migration, invasion, and epithelial-mesenchymal transition (EMT) through the expression of PITPNM3 and the activation of the NF-kappaB signaling pathway.
Data indicate that PYK2 N-terminal domain interacting receptor 1 (Nir1) could induce epithelial-mesenchymal transition by stabilising Snail via the PI3K/Akt/GSK3beta/Snail signalling pathway through binding to CCL18.
Our observations of the PITPNM3 p.Q626H mutation carriers confirm that CORD5 is a disease not to mix with other retinal degenerations mapped to 17p13.
CCL18 derived from Tumor-associated macrophages (TAMs) lays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3.
Thus, mutations in PITPNM3 do not appear to be a major cause of cone or cone-rod dystrophy.
Our finding on the first mutation in the human homologue of Drosophila rdgB indicates novel pathways and a potential important role of the PITPNM3 in mammalian phototransduction.
Mutation in the PYK2-binding domain of PITPNM3 causes autosomal dominant cone dystrophy (CORD5) in two Swedish families.
This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
, PITPnm 3
, PYK2 N-terminal domain-interacting receptor 1
, atypical chemokine receptor 6
, cone rod dystrophy 5
, membrane-associated phosphatidylinositol transfer protein 3
, phosphatidylinositol transfer protein, membrane-associated 3
, retinal degeneration B alpha 3
, pyk2 N-terminal domain-interacting receptor 1