PITPNM Family Member 3 Protéines (PITPNM3)

PITPNM3 encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. De plus, nous expédions PITPNM Family Member 3 Anticorps (35) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PITPNM3 83394 Q9BZ71
PITPNM3 327958 Q3UHE1
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$547.80
Détails

PITPNM3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour PITPNM Family Member 3 (PITPNM3) partenaires d'interaction

Human PITPNM Family Member 3 (PITPNM3) interaction partners

  1. CCL18 can increase the invasive ability of non-small cell lung cancer cells by binding to its receptor Nir1.

  2. CCL18 (Montrer CCL18 Protéines) enhances hepatocellular carcinoma (HCC (Montrer FAM126A Protéines)) cell migration, invasion, and epithelial-mesenchymal transition (EMT (Montrer ITK Protéines)) through the expression of PITPNM3 and the activation of the NF-kappaB (Montrer NFKB1 Protéines) signaling pathway.

  3. Data indicate that PYK2 N-terminal domain interacting receptor 1 (Nir1) could induce epithelial-mesenchymal transition by stabilising Snail (Montrer SNAI1 Protéines) via the PI3K (Montrer PIK3CA Protéines)/Akt (Montrer AKT1 Protéines)/GSK3beta/Snail (Montrer SNAI1 Protéines) signalling pathway through binding to CCL18 (Montrer CCL18 Protéines).

  4. Our observations of the PITPNM3 p.Q626H mutation carriers confirm that CORD5 (Montrer GUCY2D Protéines) is a disease not to mix with other retinal degenerations mapped to 17p13.

  5. CCL18 (Montrer CCL18 Protéines) derived from Tumor-associated macrophages (TAMs) lays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3.

  6. Thus, mutations in PITPNM3 do not appear to be a major cause of cone or cone-rod dystrophy.

  7. Our finding on the first mutation in the human homologue of Drosophila rdgB (Montrer PITPNM1 Protéines) indicates novel pathways and a potential important role of the PITPNM3 in mammalian phototransduction.

  8. Mutation in the PYK2 (Montrer PTK2B Protéines)-binding domain of PITPNM3 causes autosomal dominant cone dystrophy (CORD5 (Montrer GUCY2D Protéines)) in two Swedish families.

Profil protéine PITPNM Family Member 3 (PITPNM3)

Profil protéine

This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PITPNM3

  • PITPNM family member 3 (PITPNM3)
  • PITPNM family member 3 (Pitpnm3)
  • A330068P14Rik Protéine
  • Ackr6 Protéine
  • AI848332 Protéine
  • CORD5 Protéine
  • Gm880 Protéine
  • NIR1 Protéine
  • RDGBA3 Protéine

Protein level used designations for PITPNM3

NIR-1 , PITPnm 3 , PYK2 N-terminal domain-interacting receptor 1 , atypical chemokine receptor 6 , cone rod dystrophy 5 , membrane-associated phosphatidylinositol transfer protein 3 , phosphatidylinositol transfer protein, membrane-associated 3 , retinal degeneration B alpha 3 , pyk2 N-terminal domain-interacting receptor 1

GENE ID SPECIES
83394 Homo sapiens
327958 Mus musculus
489445 Canis lupus familiaris
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