POU Class 2 Associating Factor 1 (POU2AF1) Kits ELISA

Transcriptional coactivator that specifically associates with either OCT1 or OCT2. De plus, nous expédions POU2AF1 Anticorps (166) et POU2AF1 Protéines (8) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
POU2AF1 5450 Q16633
Anti-Rat POU2AF1 POU2AF1 690528  
POU2AF1 18985 Q64693
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Top POU2AF1 Kits ELISA sur anticorps-enligne.fr

Showing 3 out of 5 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests 11 to 18 Days
$838.60
Détails
Souris < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests 11 to 18 Days
$838.60
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Boeuf (Vache)
  96 Tests 15 to 18 Days
$1,029.60
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Plus Kits ELISA pour POU2AF1 partenaires d'interaction

Human POU Class 2 Associating Factor 1 (POU2AF1) interaction partners

  1. The specific objective of this study was to measure the expression of SUMO1 and POU2AF1 on first-degree relatives of patients with rheumatoid arthritis.

  2. The number of follicular B2 lymphocytes and expression of the B-cell-specific transcriptional coactivator OcaB increase with age in spleen and in intra-abdominal epididymal white adipose tissue (eWAT), concomitantly with higher circulating levels of IgG and impaired glucose homeostasis.

  3. These findings demonstrate for the first time that functional polymorphism in the 3'-UTR of POU2AF1 is associated with susceptibility, and that single-nucleotide polymorphisms interaction with hsa-miR-633 affects gene expression and increases the risk of lymphoma.

  4. Oct2 and Bob1 are very reliable in determining B cell lineage in the absence of expression of other pan-B cell markers

  5. these findings suggest a novel function of POU2AF1 as a potential regulator of host defense genes in the human airway epithelium.

  6. It has been identified as a new disease susceptibility gene among Japanese. Though different from Europeans, it is indicated that a B lymphocyte differentiation route shares a common disease developing process. [Review]

  7. Two significant susceptibility loci, TNFSF15 (rs4979462) and POU2AF1 (rs4938534) (combined odds ratio [OR] = 1.56, p = 2.84 x 10(-14) for rs4979462.

  8. genetic polymorphism is associated with common variable immunodeficiency

  9. Data show that Igh 3' enhancer-bound OCA-B and promoter-bound TFII-I mediate promoter-enhancer interactions, in both cis and trans, that are important for Igh transcription.

  10. Twenty-two cases of nodular lymphocyte predominant Hodgkin lymphoma were studied for the immunohistochemical expression of Pax-5, Oct-2, BOB.1, Bcl-6 protein and MUM1/IRF-4.

  11. On multivariate analysis, co-expression of OCT-2/BOB.1 remained predictive for achievement of complete remission and increased risk of relapse.

  12. BOB.1 may be helpful marker in the differential diagnosis of classical Hodgkin's lymphoma and primary mediastinal B-cell lymphoma

  13. The expression of the octamer cofactor gene OBF-1 (Bob1/OCA-B) is sufficient to override the silencing effects of the B29 silencer, indicating that OBF-1 plays a critical role in B cell-specific B29 promoter expression.

  14. enhances transcriptional potential of Oct1

  15. OCA-B sustains expression of the immunoglobulin-secreting program when T lymphoma and plasmacytoma lines are fused, requiring Oct-2 coregulator for its function.

  16. POU2AF1 was observed to be differentially expressed in the cells of patients with chronic lymphocytic leukemia.

  17. Alteration of the BOB1 locus does not correlate with its suppressed expression in Hodgkin lymphoma.

  18. Novel germ cell markers BOB1 were significantly upregulated in seminoma specimens, compared to normal testes.

  19. Oct-2 and its cofactor Bob-1 have an important function in mediating the IgH enhancer-bcl-2 promoter region interactions

Mouse (Murine) POU Class 2 Associating Factor 1 (POU2AF1) interaction partners

  1. The number of follicular B2 lymphocytes and expression of the B-cell-specific transcriptional coactivator OcaB increase with age in spleen and in intra-abdominal epididymal white adipose tissue (eWAT), concomitantly with higher circulating levels of IgG and impaired glucose homeostasis.

  2. Bob1 promotes the development of follicular T helper cells via Bcl6.Bob1 is directly involved in follicular T helper cell differentiation and required for mounting normal T cell-dependent B-cell responses.

  3. Findings indicate octamer transcription factor-1 (Oct1) and Oct binding factor 1 protein (OCA-B) as central mediators of CD4(+) T cell memory.

  4. overexpression of DDX60 did not potentiate IFN induction

  5. Loss of Obf1 is associated with IgM-mediated glomerulonephritis.

  6. The transcription factor Bob1 counteracts B cell activation and regulates miR-146a in B cells.

  7. Expressing a stable Bob1 mutant in B cells suppresses cell proliferation and induces changes in surface marker expression commonly seen during B-cell differentiation.

  8. Data show that IL-6 and IL-21 act with different kinetics during the germinal centers (GCs) response and that B cells, in an Oct2/OBF-1-dependent manner, can supply the IL-6 for early induction of T follicular helper cells (T(FH) development.

  9. OcaB is essential for V(D)J recombination of a subset of Igkappa genes. We show that OcaB modulates recombination by directly enhancing Igkappa gene transcription in vivo.

  10. Data show that the expression of BOB.1/OBF.1 in peripheral B cells is required for the development of marginal zone B lymphocytes.

  11. Transcriptional coactivator OBF-1 is essential for germinal center formation in Aiolos-deficient mice; lack of OBF-1 reverses several Aiolos mutant mouse phenotypes.

  12. B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice

  13. OCA-B is involved in B cell expansion as well as B cell function.

  14. it was concluded OcaB is required for normal selection of the antibody repertoire in developing B cells

  15. BOB.1/OBF.1 has a widespread effect on B cell development and function

  16. Gene expression of myosin light chain 1 atrial isoform is regulated by BOB.1/OBF.1 coactivator.

  17. OBF-1 determines the cell-autonomous capacity of B cells to undergo terminal differentiation in response to different immunological signals.

  18. OCA-B may regulate BCR signaling through an association with galectin-1.

  19. Results suggest that OCA-B is required for pre-BCR and BCR signaling at multiple stages of B cell development through its nontranscriptional regulation of SYK.

  20. The present findings establish a hierarchy between these two factors and provide a molecular link between OBF-1 and B cell receptor signaling.

POU2AF1 profil antigène

Antigen Summary

Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.

Gene names and symbols associated with POU2AF1

  • POU class 2 associating factor 1 (POU2AF1) anticorps
  • POU class 2 associating factor 1 (Pou2af1) anticorps
  • POU domain, class 2, associating factor 1 (Pou2af1) anticorps
  • Bob-1 anticorps
  • BOB.1 anticorps
  • Bob1 anticorps
  • OBF-1 anticorps
  • OBF.1 anticorps
  • OBF1 anticorps
  • OCA-B anticorps
  • OCAB anticorps

Protein level used designations for POU2AF1

B-cell-specific coactivator OBF-1 , BOB-1 , OCA-B , OCT-binding factor 1 , POU domain class 2-associating factor 1 , POU domain, class 2, associating factor 1 , OCT binding factor 1

GENE ID SPECIES
5450 Homo sapiens
528475 Bos taurus
690528 Rattus norvegicus
18985 Mus musculus
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