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POU6F2 encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. De plus, nous expédions POU Class 6 Homeobox 2 Protéines (5) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal POU6F2 Primary Antibody pour ELISA, WB - ABIN4346896
Perotti, De Vecchi, Testi, Lualdi, Modena, Mondini, Ravagnani, Collini, Di Renzo, Spreafico, Terenziani, Sozzi, Fossati-Bellani, Radice: Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14. dans Human mutation 2004
Retina-derived POU domain factor 1 coordinates expression of genes relevant to renal and neuronal development
observations suggest that POU6F2 is a tumor suppressor and is involved in hereditary predisposition to Wilms tumor
mutations in the zinc-binding domain of Apobec2 (Montrer APOBEC2 Anticorps) diminish its ability to stimulate Pou6f2 binding to DNA, and knockdown of Ubc9 (Montrer UBE2I Anticorps) or Pou6f2 suppressed retina regeneration
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
POU domain, class 6, transcription factor 2
, Wilms tumor suppressor locus
, retina-derived POU domain factor 1
, retina-derived POU-domain factor-1
, POU class 6 homeobox 2