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The protein encoded by PRDM5 is a transcription factor of the PR-domain protein family. De plus, nous expédions PRDM5 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal PRDM5 Primary Antibody pour ELISA - ABIN6242536
Watanabe, Toyota, Kondo, Suzuki, Imai, Ohe-Toyota, Maruyama, Nojima, Sasaki, Sekido, Hiratsuka, Shinomura, Imai, Itoh, Tokino: PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Inhibiting PRDM5 expression by siRNA attenuated the IFN-gamma (Montrer IFNG Anticorps)-triggered accumulation of active caspase-3 (Montrer CASP3 Anticorps) and cleaved PARP (Montrer COL11A2 Anticorps) in intestinal epithelial cells. Moreover, flow cytometry assay and CCK-8 (Montrer CCK Anticorps) analysis revealed that PRDM5 knockdown significantly alleviated the IFN-gamma-induced (Montrer SAMHD1 Anticorps) cellular apoptosis in HT29 cells.
Both Prdm 4 (Montrer PRDM4 Anticorps) and Prdm 5 are expressed in human corneal endothelium, primary hCECs and in HCECs-12 cells, characterised by expression of the Na(+)/K(+)-ATPase (Montrer ATP1A1 Anticorps).
The miR (Montrer MLXIP Anticorps)-182 promoter is rarely methylated in epithelial ovarian cancers (EOCs), and its methylation status is associated with lower miR (Montrer MLXIP Anticorps)-182 expression. Deletion of the PRDM5 locus may play a supportive role in miR (Montrer MLXIP Anticorps)-182 overexpression in EOC. miR (Montrer MLXIP Anticorps)-182 is an unfavorable prognostic factor in EOC.
The current study revealed a novel mutation in the PRDM5 gene in a Brittle cornea syndrome (BCS (Montrer BCS1L Anticorps)) family and recurrent mutation in a sporadic BCS (Montrer BCS1L Anticorps) patient.
Genetic variants in PRDM5 can lead to various syndromic and nonsyndromic disorders affecting the anterior segment of the eye.
Defective interaction of PRDM5 with repressive complexes, and dysregulation of H3K9me2, play a role in PRDM5-associated disease.
Reduced expression of PRDM5 was observed in the cornea and retina of brittle cornea syndrome patients.
These data suggest that PRDM5 is a relevant tumour suppressor gene that is frequently targeted in colorectal tumourigenesis.
PRDM2 (Montrer PRDM2 Anticorps), PRDM5, PRDM16 (Montrer PRDM16 Anticorps) promoters are methylated and their expression is suppressed in lung cancer cells.
Data provide the first causal link between Prdm5 loss and intestinal carcinogenesis, and uncover an extensive and novel PRDM5 target repertoire likely facilitating the tumor-suppressive functions of PRDM5.
Prdm5 is expressed specifically in the area of the forming neurocranium during craniofacial development.
PRDM5 regulates the expression of components of both canonical and non canonical wnt (Montrer WNT2 Anticorps) pathways and negatively modulates wnt (Montrer WNT2 Anticorps) signaling in vivo
PRDM5 promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK (Montrer MAPK8 Anticorps) expression and strategies targeting PRDM5 may be promising for the therapy of melanoma.
These data indicate how Prdm5 modulates transcription by interacting with factors involved in genome organization in mouse embryonic stem cells.
we show that Prdm5 controls both Collagen I transcription and fibrillogenesis by binding inside the Col1a1 gene body and maintaining RNA polymerase II occupancy
The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis.
PR domain containing 5
, PR domain zinc finger protein 5-like
, PR domain zinc finger protein 5
, un-named hi61
, unm hi61
, PR domain-containing protein 5