Paired Box 7 Protéines (PAX7)

PAX7 is a member of the paired box (PAX) family of transcription factors. De plus, nous expédions PAX7 Anticorps (223) et PAX7 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PAX7 5081 P23759
Rat PAX7 PAX7 500574  
PAX7 18509 P47239
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Showing 3 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days

PAX7 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
Mouse (Murine)

Plus protéines pour Paired Box 7 (PAX7) partenaires d'interaction

Turkey Paired Box 7 (PAX7) interaction partners

  1. These data suggested that expression of the myogenic regulatory transcription factors are dependent upon expression of glypican-1 and syndecan-4 during satellite cell proliferation and differentiation, and Pax7 expression is influenced by glypican-1.

Human Paired Box 7 (PAX7) interaction partners

  1. we have confirmed PAX7 reactivity in most Ewing sarcoma cases

  2. Data suggest that paired box gene 7 protein (PAX7) target gene repression is a hallmark of facioscapulohumeral muscular dystrophy (FSHD) that should be considered in the investigation of FSHD pathology and therapy.

  3. Transfection experiments showed that the PAX7 splice-site mutation putatively causes nonsense-mediated mRNA decay affecting onlyPAX7 isoform 3.

  4. The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.

  5. EWSR1 fusion protein is required for PAX7 expression in Ewing sarcoma and identify a candidate EWSR1-FLI1-bound PAX7 enhancer that coincides with both a consensus GGAA repeat-containing binding site and a peak of regulatory H3K27 acetylation.

  6. miR-206 acts as a tumor suppressor in fusion-negative RMS at least partially through downregulation of PAX7.

  7. PAX7 expression is a useful marker of skeletal muscle differentiation in rhabdomyosarcoma, particularly of the embryonal subtype, with specificity for rhabdomyosarcoma and Ewing sarcoma.

  8. NTN1 rs9788972 is identified as a risk locus for nonsyndromic orofacial clefts susceptibility in a northern Chinese population; SNPs in PAX7 were not associated with any increased risk

  9. Our results on Pax7 and MyoD protein expression suggest that proliferation and differentiation of skeletal muscle stem cells are affected in ALS patients, and the myogenic processes cannot overcome the denervation-induced wasting.

  10. these results suggest that sarcoma metastasis can be partially controlled through Pax7/MyoD-dependent activation of miR-182 and provide insight into the role that myogenic transcription factors have in sarcoma progression

  11. RAGE upregulates myogenin which upregulates MyoD and downregulates PAX7, with consequent inhibition of proliferation and stimulation of differentiation.

  12. Pax7 responds to NF-kappaB by impairing the regenerative capacity of myogenic cells in the muscle microenvironment to drive muscle wasting in cancer.

  13. High prevalence of 1p36 microdeletions in B-cell non-Hodgkin lymphomas is associated with PAX7 loss.

  14. Our study replicated previous GWAS findings for markers in VAX1 in the Asian population, and identified rare variants in PAX7 and VAX1 that may contribute to the etiology of CL(P)

  15. In addition, eight genes classified as 'second tier' hits in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and association in this replication sample.

  16. SUMOylation of Pax7 is essential for neural crest development in chick embryos and for the inhibitory roles of Pax7 in C2C12-muscle differentiation.

  17. PAX3/7-FKHR gene fusions expression was detected in 56% of ARMS tumor samples.

  18. Detection of PAX3/PAX7-FKHR fusion transcripts is a novel tool for Rhabdomyosarcoma diagnosis

  19. PAX7-FKHR fusion gene inhibits myogenic differentiation via NF-kappaB upregulation.

  20. The presence of PAX3/7-FOXO1 translocation was significantly associated with a higher frequency of metastatic disease.

Xenopus laevis Paired Box 7 (PAX7) interaction partners

  1. Our results show that the expression of Pax6 and Pax7 is widely maintained in the adult brain of Xenopus

  2. The Pax3 and Pax7 paralogs cooperate in neural and neural crest patterning using distinct molecular mechanisms, in Xenopus laevis embryos.

  3. Results show that inhibition of pax7 does not prevent differentiation of satellite cells to myofibres, but it does prevent their maintenance as a stem cell population.

Cow (Bovine) Paired Box 7 (PAX7) interaction partners

  1. The authors detected a novel 10-bp insertion/deletion (indel) polymorphism in the bovine PAX7 promoter and revealed that the indel altered the binding of the transcriptional factor ZNF219.

  2. four novel polymorphisms were identified in the Pax7 gene; the association analysis of genotypes in the single and combined SNP(s) revealed consistent effects on growth traits in NY cattle

Mouse (Murine) Paired Box 7 (PAX7) interaction partners

  1. Asymmetrically dividing muscle stem cells in skeletal muscle give rise to committed cells, where the myogenic determination factor Myf5 is transcriptionally activated by Pax7.

  2. Enhancers opened by Pax7 show a loss of DNA methylation and acquire stable epigenetic memory, as evidenced by binding of nonpioneer factors after Pax7 withdrawal. Transient Pax7 expression is sufficient for stable specification of cell identity.

  3. Prepubertal depletion of satellite cells in Pax7(CreERT2/+) ; Rosa26(DTA/+) mice reduced myofiber size and myonuclear number, and caused force generation deficits to a similar extent in both fast and slow-contracting muscles.

  4. It inhibits adipogenesis.

  5. Transfection experiments showed that the PAX7 splice-site mutation putatively causes nonsense-mediated mRNA decay affecting onlyPAX7 isoform 3.

  6. The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.

  7. Pax7 activates Zac1 to regulate GPR39 expression in myocytes.

  8. Barx2 and Pax7 regulate the canonical Wnt target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt signals.

  9. Stat3 regulates self-renewal of adult muscle satellite cells during injury-induced muscle regeneration through various partners, such as Pax7.

  10. Lkb1 activates the Notch signaling pathway, which subsequently increases Pax7 expression and promotes self-renewal and proliferation while inhibiting differentiation. Mechanistic studies reveal that Lkb1 regulates Notch activation through AMPK-mTOR pathway in myoblasts.

  11. Pax7 binding induces dramatic, localized remodeling of chromatin characterized by the acquisition of histone marks associated with enhancer activity and induction of chromatin accessibility in both muscle precursors and lineage-committed myoblasts. Conversely, removal of Pax7 leads to rapid reversal of these features on a subset of enhancers.

  12. the absence of functional Pax7 in differentiating embryonic stem cells modulates cell cycle facilitating their proliferation.

  13. findings demonstrate a key role for the lingual epithelial signals in supporting the integrity of the lamina propria and muscular tissue during tongue development and that a Wnt/Notch/Pax7 genetic hierarchy is involved in this development.

  14. results support the concept that lack of functional Pax7 promotes proliferation of differentiating ESCs and for this reason more of them can turn into myogenic lineage.

  15. the absence of functional Pax7 does not prevent the in vitro myogenic differentiation of embryonic stem cells.

  16. These results underscore DNA demethylation as a key mechanism driving myogenesis and identify specific Pax7-mediated DNA demethylation signatures to acquire and maintain the muscle-cell identity.

  17. we propose that Nedd4 functions as a novel Pax7 regulator, which activity is temporally and spatially controlled to modulate the Pax7 protein levels and therefore satellite cell fate.

  18. miR-431 transgenic mice are a unique genetic model for investigating the cellular features and biological functions of Pax7(Lo) satellite cells during muscle development and regeneration.

  19. Caspase 3 cleavage of Pax7 has a role in inhibiting self-renewal of satellite cells

  20. Brg1 functions as a positive regulator for cellular proliferation and survival of primary myoblasts via pax7.

Zebrafish Paired Box 7 (PAX7) interaction partners

  1. Cells marked by pax7a only or by both pax7a and pax7b enter the wound rapidly and contribute to muscle wound repair, but each behaves differently.

  2. Pax7 is required for adult skeletal muscle repair.

  3. Pax7 identifies neural crest, chromatophore lineages and pigment stem cells during development.

Profil protéine PAX7

Profil protéine

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Paired Box 7 Protéines (PAX7)

  • paired box 7 (PAX7)
  • paired box protein Pax-7 (PAX7)
  • paired box 7 L homeolog (pax7.L)
  • paired box protein Pax-7 (LOC536229)
  • paired box 7 (Pax7)
  • paired box 7a (pax7a)
  • HUP1 Protéine
  • Pax-7 Protéine
  • pax7 Protéine
  • PAX7B Protéine
  • pax7c Protéine
  • pax7d Protéine
  • pax7e Protéine
  • RGD1564360 Protéine
  • RMS2 Protéine

Protein level used designations for Paired Box 7 Protéines (PAX7)

paired box 7 , paired box gene 7 , transcription factor pax-7 , PAX7 transcriptional factor , paired box homeotic gene 7 , paired box protein Pax-7 , paired domain gene 7 , myogenic specification paired-box transcription factor Pax7 , paired box transcription factor PAX7 , paired box homeotic gene 7a , paired box homeotic gene 7c , paired box homeotic gene 7d , paired box homeotic gene 7e

456574 Pan troglodytes
494466 Sus scrofa
100322892 Meleagris gallopavo
100346989 Oryctolagus cuniculus
5081 Homo sapiens
496378 Xenopus laevis
395942 Gallus gallus
487408 Canis lupus familiaris
536229 Bos taurus
500574 Rattus norvegicus
18509 Mus musculus
30587 Danio rerio
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