Patatin-Like phospholipase Domain Containing 3 Protéines (PNPLA3)

The protein encoded by PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. De plus, nous expédions PNPLA3 Anticorps (85) et PNPLA3 Kits (10) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PNPLA3 80339 Q9NST1
PNPLA3 116939 Q91WW7
PNPLA3 362972  
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Showing 7 out of 9 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Escherichia coli (E. coli) Humain Inconjugué   1 mg 11 to 18 Days
Escherichia coli (E. coli) Rat Inconjugué   1 mg 11 to 18 Days
Escherichia coli (E. coli) Humain Inconjugué   5 applications 1 to 2 Days

PNPLA3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, , ,
Mouse (Murine) ,
Rat (Rattus)

PNPLA3 Protéines mieux référencés

  1. Human PNPLA3 Protein expressed in Wheat germ - ABIN1315587 : Winberg, Motlagh, Stenkula, Holm, Jones: Adiponutrin: a multimeric plasma protein. dans Biochemical and biophysical research communications 2014 (PubMed)

Plus protéines pour Patatin-Like phospholipase Domain Containing 3 (PNPLA3) partenaires d'interaction

Human Patatin-Like phospholipase Domain Containing 3 (PNPLA3) interaction partners

  1. We evaluated the effect of silymarin and the influence of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) variant on the response to treatment in patients with non-alcoholic fatty liver disease.

  2. The results of this large-scale cohort study imply that the combination of the PNPLA3 and TLL1 genotype may be associated with an increased risk of advanced fibrosis among patients with nonalcoholic fatty liver disease.

  3. PNPLA3-G/G-genotype seems to double the risks of hepatic decompensation and (liver-related) mortality in patients with portal hypertension due to fatty liver disease.

  4. Carriage of TM6SF2 rs58542926 is an additional risk factor for the development of hepatocellular carcinoma (HCC) in people with alcohol-related cirrhosis. Carriage of both PNPLA3 rs738409 and TM6SF2 rs58542926 accounts for half of the attributable risk for HCC in this population. The risk associated with carriage of MBOAT7 rs641738 was not significant.

  5. PNPLA3 rs738409 [C>G] variant occurred at a frequency of 0.46

  6. Taken together the independent associations between: (a) low bone mineral density (BMD) and PNPLA3 CG+GG genotype; (b) low BMD and non-alcoholic steatohepatitis (NASH); and (c) PNPLA3 CG+GG genotype and NASH, provide support for a causal relationship between NASH and low BMD.

  7. Participants were genotyped for PNPLA3 rs738409 and TM6SF2 rs58542926 variants. PNPLA3 G variant was independently associated with nonalcoholic fatty liver disease.

  8. Excessive gestational weight gain (GWG) was noticed in women that were overweight or obese before pregnancy. Study found a significant association between the variant genotype of GNB3 rs5443 and excessive GWG. Similarly, the presence of variant genotype of PNPLA3 rs738409 in mothers was associated with a lower ponderal index (PI) in their newborns. Study found no associations between GCKR rs780094 and birth weight or PI.

  9. PNPLA3 and TM6SF2 are common genetic variants among nonalcoholic fatty liver disease patients; both PNPLA3 I148M and TM6SF2 E167K genotypes are associated with increases in the size of low density lipoprotein and high density lipoprotein particles, phenotypes considered atheroprotective

  10. This study showed that polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with with chronic hepatitis C-related hepatocellular carcinoma development in Japanese patients with chronic hepatitis C virus infection.

  11. The risk alleles in PNPLA3, GCKR or TM6SF2 were not found to be individually associated with the presence of a disease risk factor and were not significantly more common in non-alcoholic fatty liver disease of patients with raised serum PIIINP.

  12. Non-alcoholic fatty liver disease patients carrying PNPLA3 I148M are characterized by a prominent activation of hepatic stem/progenitor cell niche.

  13. The I148M PNPLA3 variant has been identified as the major common genetic determinant of Non-alcoholic fatty liver disease.

  14. this review focuses on the genetic component of NAFLD, namely, the role of the PNPLA3 gene polymorphism in the development and course of the disease, and States its progression, such as non-alcoholic steatohepatitis, liver cirrhosis and hepatocellular carcinoma [review]

  15. Although the PNPLA3 rs738409 G allele has been associated with the risk of steatosis in chronic hepatitis B patients, no association between this polymorphism and the risk of cirrhosis was seen.

  16. In heavy drinkers, PNPLA3 GG primarily correlated with signs of liver damage (steatohepatitis, ballooning) but less with steatosis. Upon alcohol withdrawal, PNPLA3 GG carriers showed a delayed inflammation-associated resolution of liver stiffness.

  17. This study was planned to test whether follicular fluid (FF) levels of patatin-like phospholipase domain containing 3-gene (PNPLA3:adiponutrin), preptin, kisspeptin, and amylin change in polycystic ovarian syndrome.

  18. The PNPLA3 gene is associated with NAFLD in Mexican population.

  19. The association of PNPLA3 and TM6SF2 with HCC risk was confirmed in the prospective cohort with ALD. A genetic score including PNPLA3 and TM6SF2 minor alleles showed a progressive significant increased risk of HCC in ALD patients. PNPLA3-rs738409 and TM6SF2-rs58542926 are inherited risk variants of HCC development in patients with ALD in a dose dependent manner.

  20. PNPLA3 rs738409 polymorphism appears to be related to the increased progression of liver fibrosis in hepatitis C virus infected patients.

Mouse (Murine) Patatin-Like phospholipase Domain Containing 3 (PNPLA3) interaction partners

  1. conclude that the fatty liver disease associated with genetic variation in PNPLA3 is not related to the enzyme's role in remodeling lipid droplets.

  2. Histone acetylation plays a role in the modulation of PNPLA3 levels in the liver exposed to binge ethanol drinking.

  3. 148M variant disrupts ubiquitylation and proteasomal degradation

  4. Neither ablation nor overexpression of wild-type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M transgene causes steatosis.

  5. rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent.

  6. PNPLA3 plays a role in remodeling TAG in lipid droplets, as they accumulate in response to food intake

  7. adiponutrin/PNPLA3 is regulated by two key factors of the glycolytic and lipogenic pathways, raising the question of its implication in the metabolism of carbohydrates and lipids

  8. data argue against a role for Pnpla3 loss-of-function in fatty liver disease or metabolic syndrome in mice.

  9. Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin resistance in mice.

  10. Microarray-based gene profiling showed that the expression level of PNPLA3 in hepatocytes is correlated with that of genes associated with the lipogenic pathway such as ME1, SPOT14, and SCD1.

  11. data suggest that murine ATGL but not adiponutrin contributes to net adipocyte lipolysis and that ATGL and adiponutrin are oppositely regulated by insulin both in vitro and in vivo

Profil protéine PNPLA3

Profil protéine

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.

Gene names and symbols associated with PNPLA3

  • patatin like phospholipase domain containing 3 (PNPLA3)
  • patatin-like phospholipase domain containing 3 (Pnpla3)
  • Adpn Protéine
  • C22orf20 Protéine
  • iPLA(2)epsilon Protéine

Protein level used designations for PNPLA3

acylglycerol O-acyltransferase , adiponutrin , calcium-independent phospholipase A2-epsilon , iPLA2-epsilon , iPLA2epsilon , patatin-like phospholipase domain-containing protein 3

80339 Homo sapiens
116939 Mus musculus
362972 Rattus norvegicus
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