Patatin-Like phospholipase Domain Containing 3 Protéines (PNPLA3)

The protein encoded by PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. De plus, nous expédions PNPLA3 Anticorps (100) et PNPLA3 Kits (18) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PNPLA3 80339 Q9NST1
PNPLA3 116939 Q91WW7
PNPLA3 362972  
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Showing 7 out of 9 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Escherichia coli (E. coli) Rat Inconjugué   100 μg Connectez-vous pour afficher 11 to 18 Days
$582.75
Détails
Escherichia coli (E. coli) Humain Inconjugué   100 μg Connectez-vous pour afficher 11 to 18 Days
$582.75
Détails
Escherichia coli (E. coli) Humain Inconjugué   5 applications Connectez-vous pour afficher 1 to 2 Days
$318.85
Détails

PNPLA3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

PNPLA3 Protéines mieux référencés

  1. Human PNPLA3 Protein expressed in Wheat germ - ABIN1315587 : Winberg, Motlagh, Stenkula, Holm, Jones: Adiponutrin: a multimeric plasma protein. dans Biochemical and biophysical research communications 2014 (PubMed)

Plus protéines pour Patatin-Like phospholipase Domain Containing 3 (PNPLA3) partenaires d'interaction

Human Patatin-Like phospholipase Domain Containing 3 (PNPLA3) interaction partners

  1. type 2 diabetes patients with the PNPLA3 (148M/M) genotype treated with BIL may be more susceptible to increased liver fat deposition. The current data provide further insights into the biological role of PNPLA3 in lipid metabolism.

  2. Our study suggests a significant increased association between PNPLA3 rs738409 C>G polymorphism and HCC risk in the entire populations studied, especially in Caucasians. Therefore, PNPLA3 rs738409 C>G polymorphism may be a risk factor for virus and alcoholic-related HCC.

  3. Intergroup comparisons showed that the severe grade of hepatic steatosis was more frequently observed in GG than in CC carriers (74% vs. 11.3%, p < 0.001, OR 21.8). PNPLA3 CG and GG carriers with CD have a higher susceptibility to hepatic steatosis, but not to metabolic syndrome. Moreover, patients with GG alleles display more severe forms of HS based on ultrasound.

  4. The unaltered proportion of DAG (FA18:1) in I148M PNPLA3 carriers with fatty liver may explain the normal insulin sensitivity in these subjects.

  5. PNPLA3 polymorphisms were associated with advanced liver fibrosis in patients with HCV mono-Infection and HCV/HIV Co-Infection.

  6. In this longitudinal study with liver biopsy to stage liver fibrosis, we affirm there is no influence of the PNPLA3 rs738409 (GG) genotype on the occurrence of hepatocellular carcinoma in Asian chronic hepatitis C patients, including cirrhotic patients.

  7. The authors results demonstrate that SNP in the PNPLA3 gene is significantly associated with the presence and severity of NAFLD in a Korean populations.

  8. case-control study confirmed that PNPLA3 rs738409 Single Nucleotide Polymorphism is associated with Alcoholic Liver Disease.

  9. These data indicate that the liver expression of the PNPLA3 p.148M variant confers a genetic predisposition to liver graft steatosis along with nutritional status and diabetes.

  10. Findings suggest a significant association between variants in COL13A1, ADIPOQ, SAMM50, and PNPLA3, and risk of NAFLD/elevated transaminase levels in Mexican adults with an admixed ancestry.

  11. PNPLA3 determines the risk of NASH and significant fibrosis.

  12. Our study suggested that PNPLA3 loci (rs2294918, rs2294919) were associated with HBV-related HCC in Han Chinese.

  13. In this Sri Lankan community cohort study, the annual incidence of non-alcoholic fatty liver disease (NAFLD) was 6.2%. Incident NAFLD was associated with general and central obesity, raised triglycerides and diabetes, and showed a tendency of association with PNPLA3 gene polymorphisms.

  14. Deleterious and protective mutations in MTTP, PNPLA3, and TM6SF2 have been found in Japanese males at risk for non-alcoholic fatty liver disease.

  15. Although no single variant reached genome-wide significance, an association signal was observed for PNPLA3 rs738409, a common single nucleotide polymorphism that has been associated with a variety of liver-related pathologies including alcoholic cirrhosis. This preliminary analysis suggests a role for PNPLA3 variation and several gene sets/pathways that may influence risk for alcoholic hepatitis among heavy drinkers.

  16. rs738409 polymorphism was not associated with premature coronary artery disease in the whole group of participants, however, when patients and controls were divided into those with and without type 2 diabetes mellitus patients, under additive model, the polymorphism was associated with the presence of coronary artery disease only in patients with type 2 diabetes mellitus patients

  17. These findings suggest that PNPLA3 rs1010023 may predispose chronic hepatitis B patients to hepatic steatosis but protects them from glucose dysregulation by attenuating insulin resistance.

  18. Its genotype showes an association with NAFLD, NASH, fibrosis, and cirrhosis.

  19. Individuals misusing alcohol who carry a particular variant of the gene PNPLA3 are more at risk of developing severe alcoholic hepatitis.

  20. PNPLA3 is the first locus to be reproducibly and strongly associated with steatosis, fibrosis/cirrhosis in various liver diseases with different etiologies and even HCC in fatty liver diseases.

Mouse (Murine) Patatin-Like phospholipase Domain Containing 3 (PNPLA3) interaction partners

  1. Histone acetylation plays a role in the modulation of PNPLA3 levels in the liver exposed to binge ethanol drinking.

  2. 148M variant disrupts ubiquitylation and proteasomal degradation

  3. Neither ablation nor overexpression of wild-type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M transgene causes steatosis.

  4. rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent.

  5. PNPLA3 plays a role in remodeling TAG in lipid droplets, as they accumulate in response to food intake

  6. adiponutrin/PNPLA3 is regulated by two key factors of the glycolytic and lipogenic pathways, raising the question of its implication in the metabolism of carbohydrates and lipids

  7. data argue against a role for Pnpla3 loss-of-function in fatty liver disease or metabolic syndrome in mice.

  8. Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin resistance in mice.

  9. Microarray-based gene profiling showed that the expression level of PNPLA3 in hepatocytes is correlated with that of genes associated with the lipogenic pathway such as ME1, SPOT14, and SCD1.

  10. data suggest that murine ATGL but not adiponutrin contributes to net adipocyte lipolysis and that ATGL and adiponutrin are oppositely regulated by insulin both in vitro and in vivo

Profil protéine PNPLA3

Profil protéine

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.

Gene names and symbols associated with PNPLA3

  • patatin like phospholipase domain containing 3 (PNPLA3)
  • patatin-like phospholipase domain containing 3 (Pnpla3)
  • Adpn Protéine
  • C22orf20 Protéine
  • iPLA(2)epsilon Protéine

Protein level used designations for PNPLA3

acylglycerol O-acyltransferase , adiponutrin , calcium-independent phospholipase A2-epsilon , iPLA2-epsilon , iPLA2epsilon , patatin-like phospholipase domain-containing protein 3

GENE ID SPECIES
80339 Homo sapiens
116939 Mus musculus
362972 Rattus norvegicus
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