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PADI4 is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. De plus, nous expédions PADI4 Kits (16) et PADI4 Protéines (14) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 107 products:
Human Polyclonal PADI4 Primary Antibody pour ELISA, WB - ABIN250318
Wang, Wysocka, Sayegh, Lee, Perlin, Leonelli, Sonbuchner, McDonald, Cook, Dou, Roeder, Clarke, Stallcup, Allis, Coonrod: Human PAD4 regulates histone arginine methylation levels via demethylimination. dans Science (New York, N.Y.) 2004
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Cow (Bovine) Polyclonal PADI4 Primary Antibody pour WB - ABIN2785937
Costenbader, Chang, De Vivo, Plenge, Karlson: Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking. dans Arthritis research & therapy 2008
PADI4 contributes to gastric tumorigenesis by upregulating CXCR2 (Montrer CXCR2 Anticorps), KRT14 (Montrer KRT14 Anticorps) and TNF-alpha (Montrer TNF Anticorps) expression.
In this case-control study with sufficient sample size to detect associations, we observed that PADI4 SNPS rs11203367 and rs874881 do not significantly determine RA susceptibility
SNPs of PADI4 may be a risk factor for airway abnormalities in RA.
this meta-analysis suggested that PADI4 -92C/G polymorphism may be associated with the rheumatoid arthritis incidence in the Chinese population, especially for South China. Further studies conducted on other ethnic groups are required for definite conclusions.
PADI4 contributes to the pathogenesis of RA by protecting FLSs from apoptosis. PADI4 suppresses p21 (Montrer CDKN1A Anticorps) transcription through altering histone H3 (Montrer HIST3H3 Anticorps) arginine modifications on p21 (Montrer CDKN1A Anticorps) promoter region.
Proteolysis by granzyme B enhances presentation of autoantigenic PAD4 epitopes in rheumatoid arthritis.
No associations were found between clinical subtypes of JIA and PADI4 allele frequency. rs2240337 in the PADI4 gene was significantly associated with anti-cyclic citrullinated peptide antibody-positivity in juvenile idiopathic arthritis.
The effect of the PADI4-104C/T polymorphism on RA risk in the Chinese population was evaluated in a meta-analysis. The overall analysis indicated a significant association between the PADI4-104C/T polymorphism and RA risk in the Chinese population (T vs C: OR = 1.45, 95%CI = 1.18-1.78; TT vs CC: OR = 1.49, 95%CI = 1.24-1.80; TT vs CC+CT: OR = 1.28, 95%CI = 1.08-1.51; TT+CT vs CC: OR = 1.75, 95%CI = 1.30-2.37).
Overexpression of PAD4 constrains the activity of EMT (Montrer ITK Anticorps) via suppressing Elk1 (Montrer ELK1 Anticorps) expression.
Our study also demonstrated that PADI4 contributes to tumor metastasis by regulating the gene expression of insulin-like growth factor 1 (IGF1 (Montrer IGF1 Anticorps)) and WAS/WASL-interacting protein family member 1 (WIPF1 (Montrer WIPF1 Anticorps)).
PADi4 is critical for neutrophil extracellular traps formation, but is dispensable for generalized citrullination
sFlt-1 overexpression in Padi4(-/-) mice resulted in dramatically lower inflammatory and thrombotic response, which was accompanied by significant reduction in pregnancy losses. Inhibition of NETosis may serve as a novel target in disorders of impaired placentation.
a role for NETs in cardiac fibrosis and conclude that PAD4 regulates age-related organ fibrosis and dysfunction.
PADI4 exacerbates arthritis with diverse immunological modifications.
Selective inhibition of peptidylarginine deiminase IV with Cl-amidine blocked NET formation, reduced atherosclerotic lesion area, and delayed time to carotid artery thrombosis in a photochemical injury model.
Padi4 is part of the pluripotency transcriptional network, binding to regulatory elements of key stem-cell genes and activating their expression
PAD4 regulates the proliferation of multipotent progenitors in the bone marrow by controlling c-myc (Montrer MYC Anticorps) expression.
PAD4-mediated chromatin decondensation in the neutrophil is crucial for pathological venous thrombosis and present neutrophil activation and PAD4 as potential drug targets for deep vein thrombosis.
PAD4 is dispensable in this effector phase model of arthritis
analysis of regulation of histone modification and chromatin structure by the p53 (Montrer TP53 Anticorps)-PADI4 pathway
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.
peptidyl arginine deiminase, type IV
, protein-arginine deiminase type-4-like
, HL-60 PAD
, PADI-H protein
, peptidyl arginine deiminase, type V
, protein-arginine deiminase type IV
, protein-arginine deiminase type-4
, PAD type IV
, peptidylarginine deiminase IV
, peptidyl arginine deiminase, type 4
, peptidylarginine deiminase type alpha