Peptidyl Arginine Deiminase, Type IV Protéines (PADI4)

PADI4 is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. De plus, nous expédions PADI4 Anticorps (119) et PADI4 Kits (20) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PADI4 23569 Q9UM07
PADI4 18602 Q9Z183
PADI4 29512 O88807
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Top PADI4 Protéines sur anticorps-enligne.fr

Showing 10 out of 14 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,626.73
Détails
Escherichia coli (E. coli) Humain His tag   50 μg Connectez-vous pour afficher 4 Days
$522.50
Détails
Baculovirus infected Insect Cells Humain His tag,GST tag,GST tag 10 μg Connectez-vous pour afficher 14 to 16 Days
$298.32
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Baculovirus infected Insect Cells Humain His tag SDS-PAGE 50 μg Connectez-vous pour afficher 14 to 16 Days
$547.80
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,934.33
Détails
Escherichia coli (E. coli) Humain T7 tag,His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$672.00
Détails
Cellules d'insectes Souris GST tag   100 μg Connectez-vous pour afficher 25 to 30 Days
$860.64
Détails

PADI4 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , ,
, , , ,
Mouse (Murine)
,
Rat (Rattus)

Plus protéines pour Peptidyl Arginine Deiminase, Type IV (PADI4) partenaires d'interaction

Human Peptidyl Arginine Deiminase, Type IV (PADI4) interaction partners

  1. Molecular interplay between the dimer interface and the substrate-binding site of human PAD4 has been reported.

  2. PADI4 may be closely associated with hypoxiainduced autophagy, and the inhibition of hypoxiainduced autophagy by PADI4 knockdown may contribute to an increase in the apoptosis of RAFLS.

  3. MiRNA-146a rs2910164 and IRAK1 rs3027898 polymorphisms were a risk factor for predisposition to Rheumatoid Arthritis in Egyptian Population in codominant and dominant tested inheritance models, while, the miRNA-499 rs3746444 and PADI4 rs1748033 polymorphisms were a risk factor in codominant and recessive one.

  4. our meta-analysis demonstrated that the PADI4_94 polymorphisms might contribute to RA susceptibility especially in Asian populations but not in Caucasian populations.

  5. Meta-analysis indicated a significantly increased association between PADI -104C/T polymorphism and rheumatoid arthritis (RA) in Chinese and Japanese populations (which were the majority of included populations in the analysis).

  6. PADI4 interacted with SYVN1 directly and that overexpression of PADI4 suppressed the ubiquitination of proteins. Thus, a reduction in ER stress induced by PADI4 may abrogate the initiation of chronic RA by suppressing the proliferative signals of RA synoviocytes.

  7. mRNA expression of PADI2, PADI4 and Sp1 is upregulated in rheumatoid arthritis bone marrow CD34+ cells independently of the systemic inflammation or treatment regimen.

  8. this study in a Southern Mexican population suggests that PADI4 individual polymorphisms and the related susceptibility haplotype (GTG) are also genetic risk markers for rheumatoid arthritis

  9. The T allele of PADI4 rs2240340 is associated with Rheumatoid Arthritis in Asians.

  10. PADI4 contributes to gastric tumorigenesis by upregulating CXCR2, KRT14 and TNF-alpha expression.

  11. In this case-control study with sufficient sample size to detect associations, we observed that PADI4 SNPS rs11203367 and rs874881 do not significantly determine RA susceptibility

  12. SNPs of PADI4 may be a risk factor for airway abnormalities in RA.

  13. this meta-analysis suggested that PADI4 -92C/G polymorphism may be associated with the rheumatoid arthritis incidence in the Chinese population, especially for South China. Further studies conducted on other ethnic groups are required for definite conclusions.

  14. PADI4 contributes to the pathogenesis of RA by protecting FLSs from apoptosis. PADI4 suppresses p21 transcription through altering histone H3 arginine modifications on p21 promoter region.

  15. Proteolysis by granzyme B enhances presentation of autoantigenic PAD4 epitopes in rheumatoid arthritis.

  16. No associations were found between clinical subtypes of JIA and PADI4 allele frequency. rs2240337 in the PADI4 gene was significantly associated with anti-cyclic citrullinated peptide antibody-positivity in juvenile idiopathic arthritis.

  17. The effect of the PADI4-104C/T polymorphism on RA risk in the Chinese population was evaluated in a meta-analysis. The overall analysis indicated a significant association between the PADI4-104C/T polymorphism and RA risk in the Chinese population (T vs C: OR = 1.45, 95%CI = 1.18-1.78; TT vs CC: OR = 1.49, 95%CI = 1.24-1.80; TT vs CC+CT: OR = 1.28, 95%CI = 1.08-1.51; TT+CT vs CC: OR = 1.75, 95%CI = 1.30-2.37).

  18. Overexpression of PAD4 constrains the activity of EMT via suppressing Elk1 expression.

  19. Our study also demonstrated that PADI4 contributes to tumor metastasis by regulating the gene expression of insulin-like growth factor 1 (IGF1) and WAS/WASL-interacting protein family member 1 (WIPF1).

  20. PAD4 levels were significantly higher in patients with rheumatoid arthritis than in patients with systemic lupus erythematosis or healthy controls. Anti-PAD4 antibodies were detected in 30% of patients with rheumatoid arthritis, but not in patients with SLE, systemic sclerosis or controls.

Mouse (Murine) Peptidyl Arginine Deiminase, Type IV (PADI4) interaction partners

  1. PAD4 in neutrophils is essential for kidney NET formation and ischemic kidney injury.

  2. PADi4 is critical for neutrophil extracellular traps formation, but is dispensable for generalized citrullination

  3. sFlt-1 overexpression in Padi4(-/-) mice resulted in dramatically lower inflammatory and thrombotic response, which was accompanied by significant reduction in pregnancy losses. Inhibition of NETosis may serve as a novel target in disorders of impaired placentation.

  4. a role for NETs in cardiac fibrosis and conclude that PAD4 regulates age-related organ fibrosis and dysfunction.

  5. PADI4 exacerbates arthritis with diverse immunological modifications.

  6. Selective inhibition of peptidylarginine deiminase IV with Cl-amidine blocked NET formation, reduced atherosclerotic lesion area, and delayed time to carotid artery thrombosis in a photochemical injury model.

  7. Padi4 is part of the pluripotency transcriptional network, binding to regulatory elements of key stem-cell genes and activating their expression

  8. PAD4 regulates the proliferation of multipotent progenitors in the bone marrow by controlling c-myc expression.

  9. peptidyl-arginine deiminases inhibiion reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis.

  10. PAD4-mediated chromatin decondensation in the neutrophil is crucial for pathological venous thrombosis and present neutrophil activation and PAD4 as potential drug targets for deep vein thrombosis.

  11. PAD4 is dispensable in this effector phase model of arthritis

  12. analysis of regulation of histone modification and chromatin structure by the p53-PADI4 pathway

  13. An increase in citrullinated proteins resulting from increased PAD2 and 4 is an important change in the pathogenesis of multiple sclerosis.

Profil protéine PADI4

Profil protéine

This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.

Gene names and symbols associated with PADI4

  • peptidyl arginine deiminase 4 (PADI4)
  • peptidyl arginine deiminase, type IV (Padi4)
  • peptidyl arginine deiminase 4 (Padi4)
  • PAD Protéine
  • Pad4 Protéine
  • PADI5 Protéine
  • Pdi4 Protéine
  • PDI5 Protéine

Protein level used designations for PADI4

peptidyl arginine deiminase, type IV , protein-arginine deiminase type-4-like , HL-60 PAD , PADI-H protein , peptidyl arginine deiminase, type V , protein-arginine deiminase type IV , protein-arginine deiminase type-4 , PAD type IV , peptidylarginine deiminase IV , PAD-R4 , peptidyl arginine deiminase, type 4 , peptidylarginine deiminase type alpha

GENE ID SPECIES
100026011 Monodelphis domestica
100049826 Equus caballus
100415489 Callithrix jacchus
100471129 Ailuropoda melanoleuca
100592291 Nomascus leucogenys
23569 Homo sapiens
18602 Mus musculus
456530 Pan troglodytes
29512 Rattus norvegicus
606921 Canis lupus familiaris
508161 Bos taurus
100524749 Sus scrofa
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