anti-Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) Anticorps

PPIA encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. De plus, nous expédions PPIA Kits (77) et PPIA Protéines (57) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PPIA 5478 P62937
PPIA 25518 P10111
PPIA 268373 P17742
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Top anti-PPIA Anticorps sur anticorps-enligne.fr

Showing 10 out of 248 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-PPIA Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human brain 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué IHC (p), WB Western blot analysis of Cyclophilin A using anti- Cyclophilin A antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat lung tissue lysates,   Lane 2: rat brain tissue lysates,   Lane 3: mouse lung tissue lysates,  Lane 4: HELA whole Cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- Cyclophilin A antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for Cyclophilin A at approximately 18KD. The expected band size for Cyclophilin A is at 18KD. IHC analysis of Cyclophilin A using anti-Cyclophilin A antibody . Cyclophilin A was detected in immunocytochemical section of THP-1 cell. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml rabbit anti-Cyclophilin A Antibody  overnight at 4°C. DyLight®488 Conjugated Avidin was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1094) with DAB as the chromogen. 100 μg Connectez-vous pour afficher 4 to 6 Days
$280.00
Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Chèvre Inconjugué ELISA, WB ABIN185542 (2µg/ml) staining of human lymph node lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 6 to 7 Days
$358.02
Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), WB WB Image Cyclophilin A antibody detects Cyclophilin A protein by western blot analysis. Raji whole cell extracts and cytoplasma+membrane and nuclear extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Cyclophilin A antibody , at a dilution of 1:5000. IHC-P Image Immunohistochemical analysis of paraffin-embedded MDA-MB-468 xenograft, using Cyclophilin A, antibody at 1:500 dilution. 100 μL Connectez-vous pour afficher 1 to 2 Days
$358.60
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-PPIA Antibody Titration:  2.5ug/ml  Positive Control:  HepG2 cell lysate PPIA is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells Human Intestine 100 μL Connectez-vous pour afficher 2 to 3 Days
$229.00
Détails
Humain Lapin Inconjugué FACS, IHC (p), WB Western blot analysis of PPIA Antibody (N-term) (ABIN389487) in T47D cell line and mouse brain,bladder tissue lysates (35 µg/lane). PPIA (arrow) was detected using the purified polyclonal antibody.(2 µg/mL) Formalin-fixed and paraffin-embedded human brain tissue reacted with PPIA Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 10 to 11 Days
$335.50
Détails
Humain Lapin Inconjugué ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Rat Brain, antibody was diluted at 1:100. 100 μL Connectez-vous pour afficher 16 Days
$181.73
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: Cyclophilin A Antibody [NBP1-30993] - Paraffin-embedded MDA-MB-468 xenograft, using antibody at 1:500 dilution. Western Blot: Cyclophilin A Antibody [NBP1-30993] - Raji whole cell extracts and cytoplasma+membrane and nuclear extracts (30 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with Cyclophilin A antibody at a dilution of 1:5000. 100 μL Connectez-vous pour afficher 8 to 11 Days
$514.63
Détails
Boeuf (Vache) Chèvre Inconjugué EIA, WB   0.1 mg Connectez-vous pour afficher Disponible
$462.00
Détails

anti-PPIA Anticorps mieux référencés

  1. Human Monoclonal PPIA Primary Antibody pour ELISA, WB - ABIN562340 : Rho, Roehrl, Wang: Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma. dans Journal of proteome research 2009 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal PPIA Primary Antibody pour IF (p), IHC (p) - ABIN759716 : Kang, Kim, Hong, Park, Heinsen, Lee, Ravid, Ferrer, Yoo, Kwon, Park: Large-scale analysis of posttranslational modifications in the hippocampus of patients with Alzheimer's disease using pI shift and label-free quantification without enrichment. dans Analytical and bioanalytical chemistry 2014 (PubMed)

  3. Human Polyclonal PPIA Primary Antibody pour ELISA, WB - ABIN250906 : Berthoux, Sebastian, Sokolskaja, Luban: Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells. dans Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)

  4. Human Polyclonal PPIA Primary Antibody pour IHC, IHC (p) - ABIN4301644 : Yamamoto, Kudo, Peng, Takata, Takakura, Teduka, Fujii, Mitamura, Taga, Uchida, Naito: Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue. dans Tumour biology 2016 (PubMed)

Plus d’anticorps contre PPIA partenaires d’interaction

Xenopus laevis Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

Human Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

  1. Here, the binding site of AIF (Montrer AIFM1 Anticorps)(Delta1-121) and AIF (Montrer AIFM1 Anticorps)(370-394) on CypA has been mapped by NMR spectroscopy and biochemical studies, and a molecular model of the complex has been proposed. The authors show that AIF (Montrer AIFM1 Anticorps)(370-394) interacts with CypA on the same surface recognized by AIF (Montrer AIFM1 Anticorps)(Delta1-121) protein and that the region is very close to the CypA catalytic pocket.

  2. CyPA was significantly increased in convalescent COPD (Montrer ARCN1 Anticorps) patients and further elevated in COPD (Montrer ARCN1 Anticorps) patients with acute exacerbation.

  3. CypA expression was not an independent prognostic factor, but correlated with poor prognosis of lung adenocarcinoma

  4. Extracellular cyclophilin A augments platelet-dependent thrombosis and thromboinflammation.

  5. the increased expression of CyPA in ectopic endometrial tissue is associated with endometrioma recurrences and vascularity.

  6. Taken together, these findings reveal an essential role of CypA in boosting RIG-I (Montrer DDX58 Anticorps)-mediated antiviral immune responses by controlling the ubiquitination of RIG-I (Montrer DDX58 Anticorps) and MAVS (Montrer MAVS Anticorps).

  7. Data show that cyclophilin A (CypA) is up-regulated in oral squamous cell carcinoma (OSCC) arising from oral submucous fibrosis (OSF (Montrer OSTF1 Anticorps)).

  8. K308 of NS5A is indispensable for both RNA and NS5B binding, whereas W316 is essential for protein-protein interactions with CypA and NS5B.

  9. PPIA is differentially expressed in lesional biopsy specimens from patients with atopic eczema relative to normal skin

  10. inosine-5'-monophosphate dehydrogenase 2 (IMPDH2 (Montrer IMPDH2 Anticorps)) is an intracellular target of the PPIA-Sanglifehrin A binary complex.

Mouse (Murine) Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) interaction partners

  1. Extracellular cyclophilin A augments platelet-dependent thrombosis and thromboinflammation.

  2. Endothelial cell-derived CypA (especially AcK (Montrer TNK2 Anticorps)-CypA) causes pulmonary artery hypertension by a presumptive mechanism involving increased EC apoptosis, inflammation, and oxidative stress.

  3. ox-LDL-induced CyPA secretion requires vesicle transportation, actin remodeling and ROCK-dependent diphosphorylation of myosin light chains in vascular smooth muscle cells.

  4. knockdown of CD147 on Hepa1-6 cells resulted in significantly increased T cells chemotaxis induced by CypA both in vivo and in vitro.

  5. CypA dually exerts pro-osteogenic and anti-osteoclastic effects.

  6. Extracellular CyPA activates platelets via cluster of differentiation 147-mediated phosphoinositid-3-kinase/Akt (Montrer AKT1 Anticorps)-signaling, leading to enhanced adhesion and thrombus formation independently of intracellular CyPA.

  7. CypA provided stability for NF-kappaB (Montrer NFKB1 Anticorps) p65 (Montrer NFkBP65 Anticorps) and promoted NF-kappaB (Montrer NFKB1 Anticorps) p65 (Montrer NFkBP65 Anticorps) nuclear translocation, resulting in increased nuclear accumulation and enhanced NF-kappaB (Montrer NFKB1 Anticorps) activity.

  8. Newborn CypA-deficient pups exhibited generalized, pronounced skeletal defects, while high-resolution micro-computed tomography analyses of the femurs and lumbar vertebrae revealed delayed or incomplete endochondral ossification.

  9. Cyclophilin A secretion was increased in lymphocytes from atherogenic mice.

  10. CD137 (Montrer TNFRSF9 Anticorps)-CD137L (Montrer TNFSF9 Anticorps) interactions mediated via regulation of CyPA contribute to the progression of atherosclerosis.

PPIA profil antigène

Profil protéine

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.

Gene names and symbols associated with PPIA

  • peptidylprolyl isomerase A (PPIA) anticorps
  • peptidylprolyl isomerase Aa (cyclophilin A) (ppiaa) anticorps
  • peptidylprolyl isomerase A (cyclophilin A) L homeolog (ppia.L) anticorps
  • cyclophilin A (Cypa) anticorps
  • cyclophilin A (CNB01230) anticorps
  • cyclophilin A (CNB01290) anticorps
  • cyclophilin A (Tc00.1047053506925.300) anticorps
  • cyclophilin A (Tb11.03.0250) anticorps
  • cyclophilin a (CYPA) anticorps
  • peptidylprolyl isomerase A (cyclophilin A) (Ppia) anticorps
  • peptidylprolyl isomerase A (cyclophilin A) (ppia) anticorps
  • peptidylprolyl isomerase A (Ppia) anticorps
  • peptidylprolyl isomerase A (cyclophilin A) (PPIA) anticorps
  • 2700098C05 anticorps
  • Cphn anticorps
  • CYCA anticorps
  • CyP-18 anticorps
  • CyP-A anticorps
  • Cyp1 anticorps
  • cypA anticorps
  • CYPH anticorps
  • fa93g09 anticorps
  • MGC75715 anticorps
  • MT-ND1 anticorps
  • MTND1 anticorps
  • NADH1 anticorps
  • ND1 anticorps
  • ppia anticorps
  • PPIA-2 anticorps
  • PPIase A anticorps
  • wu:fa93g09 anticorps
  • wu:fb05e11 anticorps
  • wu:fb13h02 anticorps
  • wu:fb15a05 anticorps

Protein level used designations for PPIA

PPIase A , cyclophilin A , cyclophilin T , cyclophilin T-cell , cyclosporin A-binding protein , peptidyl-prolyl cis-trans isomerase A , rotamase A , 2-peptidylprolyl isomerase A , peptidylprolyl isomerase A (cyclophilin A) , cyclophilin 18 , immunophilin , cyclophilin-like , T cell cyclophilin , cyclophilin , cyclophilin a , p1B15 , p31 , Cyclophilin A , Cyclosporin A-binding protein , Rotamase A , SP18 , NADH dehydrogenase subunit 1 , NADH-ubiquinone oxidoreductase chain 1 , Peptidyl-prolyl cis-trans isomerase A

GENE ID SPECIES
281418 Bos taurus
336612 Danio rerio
100008724 Oryctolagus cuniculus
397637 Sus scrofa
463386 Pan troglodytes
398630 Xenopus laevis
692737 Bombyx mori
574102 Macaca mulatta
5478 Homo sapiens
3255869 Cryptococcus neoformans var. neoformans JEC21
3255972 Cryptococcus neoformans var. neoformans JEC21
3554513 Trypanosoma cruzi strain CL Brener
3664945 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5652501 Leishmania major strain Friedlin
25518 Rattus norvegicus
394470 Xenopus (Silurana) tropicalis
100594480 Nomascus leucogenys
268373 Mus musculus
776282 Gallus gallus
608151 Canis lupus familiaris
100173012 Pongo abelii
493966 Felis catus
443258 Ovis aries
100973085 Pan paniscus
100722609 Cavia porcellus
100769490 Cricetulus griseus
101925040 Macaca fascicularis
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