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PER2 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. De plus, nous expédions PER2 Anticorps (109) et PER2 Protéines (4) et beaucoup plus de produits pour cette protéine.
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Data suggest that Per2 is not only a tumor suppressor gene but can also be regarded as a regulator of MDM2 (Montrer MDM2 Kits ELISA)-TP53 (Montrer TP53 Kits ELISA) pathway.
the clock gene PER2 polymorphisms account for the physiological variation of melatonin suppression as circadian light sensitivity
This study showed that Lack of Association between Genetic Polymorphism of PER2 gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population
Results show that PER2 expression and stability is regulated by CSNK1D (Montrer CSNK1D Kits ELISA) which can itself be regulated by phosphorylation on its regulatory domain in a site-specific manner.
miR (Montrer MLXIP Kits ELISA)-21 as cardioprotective downstream target of Per2
Per2 is closely and negatively associated with the occurrence and development of ovarian cancer. Per2 expression, and the clinical stage and TNM (Montrer ODZ1 Kits ELISA) development of ovarian cancer were identified to be correlated.
results indicate the involvement of PER2 in the homeostatic process of sleep
Immunostaining of CLOCK and PER2 protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation
clock gene Per2 plays an important role in cell cycle progression and the balance of cell proliferation and apoptosis by regulation of the cyclin/CDK/CKI cell cycle network.
Low Per2 gene expression is associated with colorectal liver metastases.
Atxn2 (Montrer ATXN2 Kits ELISA)(-/-) mice showed an unstable rhythmicity of locomotor activity, but the level of PER1 (Montrer PER1 Kits ELISA) and PER2 IR in the SCN (Montrer SRI Kits ELISA) did not differ between genotypes.
A knockin mouse expressing a fluorescent fusion of native PER2 protein (PER2::VENUS) for live imaging showed how the mobility and nuclear translocation of PER2 are regulated by casein kinase.
Data indicate that following removal of tetrodotoxin (TTX), the dorsal region attained a stable period after the ventral region and an earlier time of peak PERIOD2 (PER2) expression.
Data show that extracellular luciferin concentration significantly affects the apparent circadian amplitude and phase of PER2::LUC reporter in cultured fibroblasts, but not in suprachiasmatic nucleus (SCN (Montrer SRI Kits ELISA)).
The Per2 function in the bone marrow is required for the regulation of life span in circulating erythrocytes.
these results identify Per2 as a negative regulator of Ly-biased haematopoietic stem cells and immune functions in response to DNA damage and ageing.
beta-amyloid protein (31-35) altered the expression of the Per1 and Per2 in the suprachiasmatic nucleus, hippocampus and heart. These findings provide experimental evidence for circadian rhythm disturbances in patients with Alzheimer's disease.
Circadian PER2 rhythm in the olfactory bulb of freely moving mice is organized by the nucleus circadian pacemaker, and is independent of the circadian behavioral rhythm
Study showed that Mecp2 de fi ciency causes a reduced amplitude in the PER2 expression rhythms of the suprachiasmatic nucleus providing a new insight into behavioral dysfunction caused by Mecp2 de fi ciency in Rett syndrome.
Upon inhibition of protein synthesis, D-box mediated gene expression is abolished while the E-box confers light driven activation as observed in the per2 gene.
Opposing effects of circadian clock genes bmal1 and period2 in regulation of VEGF-dependent angiogenesis in developing zebrafish.
light-dependent crosstalk between E- and D-box binding factors is a central determinant of per2 expression.
PER2 regulates the sub-cellular distributions of zCLOCK and zBMAL proteins.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
circadian clock protein PERIOD 2
, period 2
, period circadian protein 2
, period circadian protein homolog 2
, period homolog 2
, period circadian clock 2