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PER2 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. De plus, nous expédions PER2 Anticorps (105) et PER2 Kits (8) et beaucoup plus de produits pour cette protéine.
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The results of this study suggest that loss of PER2 expression is closely associated with the genesis and development of OSCC and that PER2 may be an important prognostic biomarker in OSCC.
Results indicate that PER2 plays a similar role in both mouse and human mammary epithelial cells and regulates cell fate commitment, with a trend towards a bipotent cell type
The interplay between Sirt1 (Montrer SIRT1 Protéines) and Per2 modulates aging gene expression and circadian-clock maintenance.
The results suggest that the PER2 gene may be a risk factor for RA, and expression of the PER2 protein may be affected by inflammation. Therefore, PER2 may contribute to the pathogenesis of RA.
p53 (Montrer TP53 Protéines)'s nuclear shuttling was significantly favored by ectopic expression of Per2 and reduced because of Per2 down-regulation.
In human oral squamous cell carcinoma cells PER2 through the regulation of the numerous important downstream tumor-related genes, plays a major role in tumor suppression.
Data suggest that Per2 is not only a tumor suppressor gene but can also be regarded as a regulator of MDM2 (Montrer MDM2 Protéines)-TP53 (Montrer TP53 Protéines) pathway.
the clock gene PER2 polymorphisms account for the physiological variation of melatonin suppression as circadian light sensitivity
This study showed that Lack of Association between Genetic Polymorphism of PER2 gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population
Results show that PER2 expression and stability is regulated by CSNK1D (Montrer CSNK1D Protéines) which can itself be regulated by phosphorylation on its regulatory domain in a site-specific manner.
Studied roles of CK1delta and CK1e in regulation of PER2 in circadian rhythm.
Collectively, SIK3 plays key roles in circadian rhythms by facilitating phosphorylation-dependent PER2 destabilization, either directly or indirectly.
The regulatory role of Per2 3'- UTR in circadian rhythm and PER2 protein accumulation.
proposal of models to determine the regulatory role Per2AS plays in the mammalian circadian clock and potential effects of interactions between Per2 and Per2AS RNAs on circadian rhythms
Results show that Per1 (Montrer PER1 Protéines) expression is associated with a short period and Per2 expression is associated with a long period and, that Per1 (Montrer PER1 Protéines) and Per2 cooperatively confine the range of circadian period length to approximately 24-h.
PML (Montrer PML Protéines) mediates the binding of PER2 to BMAL1 (Montrer ARNTL Protéines) in the BMAL1 (Montrer ARNTL Protéines)/CLOCK heterodimer and is an important component in the organization of a functional clock complex in the nucleus.
PER2 is required for proper mouse mammary gland development and thus has a crucial role outside of its circadian function.
Data suggest that, in the SCN (Montrer SRI Protéines) (suprachiasmatic nucleus), the day-night difference in PER2 expression is similar between chow-fed and fcHFHS-fed mice; in the LHb (Montrer LHB Protéines) (epithalamic lateral habenula), this day-night difference is altered in fcHFHS-fed mice compared to chow-fed mice. (fcHFHS = free choice high-fat high-sugar diet)
bioluminescence rhythm of peripheral clocks in PER2::LUC mice was strongly entrained by forced treadmill and forced wheel-running exercise rather than by voluntary wheel-running exercise at middle time during the inactivity period. Exercise-induced entrainment was accompanied by increased levels of serum corticosterone and norepinephrine in peripheral tissues, similar to the physical stress-induced response
Using a wounded zebrafish inflammation model, the authors found that under constant dark conditions (DD), the expression of pro-inflammatory cytokines is significantly downregulated in per1b gene mutant zebrafish and significantly upregulated in the per2 gene mutant zebrafish.
Upon inhibition of protein synthesis, D-box mediated gene expression is abolished while the E-box confers light driven activation as observed in the per2 gene.
Opposing effects of circadian clock genes bmal1 (Montrer ARNTL Protéines) and period2 in regulation of VEGF (Montrer VEGFA Protéines)-dependent angiogenesis in developing zebrafish.
light-dependent crosstalk between E- and D-box binding factors is a central determinant of per2 expression.
PER2 regulates the sub-cellular distributions of zCLOCK and zBMAL proteins.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
circadian clock protein PERIOD 2
, period 2
, period circadian protein 2
, period circadian protein homolog 2
, period homolog 2
, period circadian clock 2