Period Homolog 2 (Drosophila) Protéines (PER2)

PER2 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. De plus, nous expédions PER2 Anticorps (111) et PER2 Kits (8) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PER2 8864 O15055
PER2 18627 O54943
PER2 63840 Q9Z301
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Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
Escherichia coli (E. coli) Rat S tag,His tag 100 μg Connectez-vous pour afficher 15 to 18 Days

PER2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour Period Homolog 2 (Drosophila) (PER2) partenaires d'interaction

Human Period Homolog 2 (Drosophila) (PER2) interaction partners

  1. The computational and experimental approaches suggest SIRT1 positively regulates circadian clock function through actions on PER2 and PGC1a.

  2. These results indicate that the loss of Per2 is one of the factors underlying tumourigenesis in nonsmall cell lung cancer , and it may function as a novel molecular target for nonsmall cell lung cancer .

  3. The results of this study suggest that loss of PER2 expression is closely associated with the genesis and development of OSCC and that PER2 may be an important prognostic biomarker in OSCC.

  4. Results indicate that PER2 plays a similar role in both mouse and human mammary epithelial cells and regulates cell fate commitment, with a trend towards a bipotent cell type

  5. The interplay between Sirt1 and Per2 modulates aging gene expression and circadian-clock maintenance.

  6. The results suggest that the PER2 gene may be a risk factor for RA, and expression of the PER2 protein may be affected by inflammation. Therefore, PER2 may contribute to the pathogenesis of RA.

  7. p53's nuclear shuttling was significantly favored by ectopic expression of Per2 and reduced because of Per2 down-regulation.

  8. In human oral squamous cell carcinoma cells PER2 through the regulation of the numerous important downstream tumor-related genes, plays a major role in tumor suppression.

  9. Data suggest that Per2 is not only a tumor suppressor gene but can also be regarded as a regulator of MDM2-TP53 pathway.

  10. the clock gene PER2 polymorphisms account for the physiological variation of melatonin suppression as circadian light sensitivity

  11. This study showed that Lack of Association between Genetic Polymorphism of PER2 gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population

  12. Results show that PER2 expression and stability is regulated by CSNK1D which can itself be regulated by phosphorylation on its regulatory domain in a site-specific manner.

  13. miR-21 as cardioprotective downstream target of Per2

  14. Per2 is closely and negatively associated with the occurrence and development of ovarian cancer. Per2 expression, and the clinical stage and TNM development of ovarian cancer were identified to be correlated.

  15. results indicate the involvement of PER2 in the homeostatic process of sleep

  16. Immunostaining of CLOCK and PER2 protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation

  17. clock gene Per2 plays an important role in cell cycle progression and the balance of cell proliferation and apoptosis by regulation of the cyclin/CDK/CKI cell cycle network.

  18. Low Per2 gene expression is associated with colorectal liver metastases.

  19. The levels of circadian protein Per2 were significantly increased and E-cadherin was significantly decreased in the tissue of human esophageal cancer with metastasis as compared with non-metastatic esophageal cancer.

  20. The effect of genotype AC or allele C of Per2 on insomnia was relatively stronger than that of high work stress, suggesting that individual's susceptibility should be taken into consideration when intervening and controlling insomnia of workers.

Mouse (Murine) Period Homolog 2 (Drosophila) (PER2) interaction partners

  1. This study found that oncogene-transformed embryonic fibroblasts prepared from Per2-mutant (Per2(m/m) ) mice, which are susceptible to both spontaneous and radiation-induced tumorigenesis, were resistant against common chemotherapeutic drugs and that this resistance is associated with up-regulation of the aldehyde dehydrogenase 3a1 (Aldh3a1) gene.

  2. Study shows abnormal circadian locomotor rhythms and Per1 and Per 2 gene expression in six-month-old triple transgenic mice model of Alzheimer's disease.

  3. Period genes not only orchestrate dynamic changes in metabolic activity, but also regulate homeostatic self-renewal of hepatocytes through Mkp1-Erk1/2 signaling pathway.

  4. Studied roles of CK1delta and CK1e in regulation of PER2 in circadian rhythm.

  5. Collectively, SIK3 plays key roles in circadian rhythms by facilitating phosphorylation-dependent PER2 destabilization, either directly or indirectly.

  6. The regulatory role of Per2 3'- UTR in circadian rhythm and PER2 protein accumulation.

  7. proposal of models to determine the regulatory role Per2AS plays in the mammalian circadian clock and potential effects of interactions between Per2 and Per2AS RNAs on circadian rhythms

  8. Results show that Per1 expression is associated with a short period and Per2 expression is associated with a long period and, that Per1 and Per2 cooperatively confine the range of circadian period length to approximately 24-h.

  9. PML mediates the binding of PER2 to BMAL1 in the BMAL1/CLOCK heterodimer and is an important component in the organization of a functional clock complex in the nucleus.

  10. PER2 is required for proper mouse mammary gland development and thus has a crucial role outside of its circadian function.

  11. Data suggest that, in the SCN (suprachiasmatic nucleus), the day-night difference in PER2 expression is similar between chow-fed and fcHFHS-fed mice; in the LHb (epithalamic lateral habenula), this day-night difference is altered in fcHFHS-fed mice compared to chow-fed mice. (fcHFHS = free choice high-fat high-sugar diet)

  12. The interplay between Sirt1 and Per2 modulates aging gene expression and circadian-clock maintenance.

  13. bioluminescence rhythm of peripheral clocks in PER2::LUC mice was strongly entrained by forced treadmill and forced wheel-running exercise rather than by voluntary wheel-running exercise at middle time during the inactivity period. Exercise-induced entrainment was accompanied by increased levels of serum corticosterone and norepinephrine in peripheral tissues, similar to the physical stress-induced response

  14. Expression of Per2 and Bmal1 in the ovary did not display clear diurnal oscillation.

  15. Per2 acted here as a liver tumor suppressor from initiation to progression.

  16. Atxn2(-/-) mice showed an unstable rhythmicity of locomotor activity, but the level of PER1 and PER2 IR in the SCN did not differ between genotypes.

  17. A knockin mouse expressing a fluorescent fusion of native PER2 protein (PER2::VENUS) for live imaging showed how the mobility and nuclear translocation of PER2 are regulated by casein kinase.

  18. Data indicate that following removal of tetrodotoxin (TTX), the dorsal region attained a stable period after the ventral region and an earlier time of peak PERIOD2 (PER2) expression.

  19. Data show that extracellular luciferin concentration significantly affects the apparent circadian amplitude and phase of PER2::LUC reporter in cultured fibroblasts, but not in suprachiasmatic nucleus (SCN).

  20. The Per2 function in the bone marrow is required for the regulation of life span in circulating erythrocytes.

Zebrafish Period Homolog 2 (Drosophila) (PER2) interaction partners

  1. Using a wounded zebrafish inflammation model, the authors found that under constant dark conditions (DD), the expression of pro-inflammatory cytokines is significantly downregulated in per1b gene mutant zebrafish and significantly upregulated in the per2 gene mutant zebrafish.

  2. Upon inhibition of protein synthesis, D-box mediated gene expression is abolished while the E-box confers light driven activation as observed in the per2 gene.

  3. Opposing effects of circadian clock genes bmal1 and period2 in regulation of VEGF-dependent angiogenesis in developing zebrafish.

  4. light-dependent crosstalk between E- and D-box binding factors is a central determinant of per2 expression.

  5. PER2 regulates the sub-cellular distributions of zCLOCK and zBMAL proteins.

  6. Analysis of zper2 mRNA expression in zebrafish embryos exposed to different photoperiodic regimes indicated that zper2 expression is transiently up-regulated by light but is not regulated by the circadian oscillator.

  7. Period2 has a role in the development of the pineal circadian clock in zebrafish [review]

  8. Treatment of light responsive cells with hydrogen peroxide triggers induction of this gene.

Profil protéine PER2

Profil protéine

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.

Gene names and symbols associated with PER2

  • period circadian regulator 2 (PER2)
  • period circadian clock 2 (Per2)
  • period circadian clock 2 (PER2)
  • period circadian clock 2 (per2)
  • FASPS Protéine
  • FASPS1 Protéine
  • fj43b09 Protéine
  • gPer2 Protéine
  • mKIAA0347 Protéine
  • mPer2 Protéine
  • rPER2 Protéine
  • wu:fj43b09 Protéine

Protein level used designations for PER2

circadian clock protein PERIOD 2 , hPER2 , period 2 , period circadian protein 2 , period circadian protein homolog 2 , period homolog 2 , cPER2 , period circadian clock 2 , per2a , zper2

8864 Homo sapiens
100221513 Taeniopygia guttata
18627 Mus musculus
63840 Rattus norvegicus
374116 Gallus gallus
100034167 Equus caballus
140633 Danio rerio
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