Peroxisomal Biogenesis Factor 19 Protéines (PEX19)

PEX19 is necessary for early peroxisomal biogenesis. De plus, nous expédions PEX19 Anticorps (87) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PEX19 5824 P40855
PEX19 19298 Q8VCI5
PEX19 289233  
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Showing 10 out of 17 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Humain Inconjugué 0.1 mg 2 to 3 Days
Escherichia coli (E. coli) Humain His tag 100 μg 15 to 18 Days
Escherichia coli (E. coli) Souris His tag 100 μg 15 to 18 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Escherichia coli (E. coli) Humain Inconjugué SDS-PAGE analysis of Human PEX19 Protein. 100 μg 11 to 18 Days
Escherichia coli (E. coli) Souris Inconjugué SDS-PAGE analysis of Mouse PEX19 Protein. 100 μg 11 to 18 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Humain His tag 100 μg 15 to 19 Days

PEX19 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Plus protéines pour Peroxisomal Biogenesis Factor 19 (PEX19) partenaires d'interaction

Fruit Fly (Drosophila melanogaster) Peroxisomal Biogenesis Factor 19 (PEX19) interaction partners

  1. a Drosophila Pex19 mutant is lethal due to a deficit in medium-chain fatty acids

Human Peroxisomal Biogenesis Factor 19 (PEX19) interaction partners

  1. studies indicate that Pex3 and Pex19 can also facilitate sorting of certain membrane proteins to other cellular organelles, including the endoplasmic reticulum, lipid droplets, and mitochondria

  2. The summarize recent insights into the biogenesis and function of Lipid droplets and peroxisomes with emphasis on the role of PEX19 in these processes.

  3. Hnf4-induced lipotoxicity and accumulation of free fatty acids is the cause for mitochondrial damage in consequence of peroxisome loss in Pex19 mutants

  4. Thus, PEX19 and PEX3 peroxisome biogenesis factors provide an alternative posttranslational route for membrane insertion of the reticulon homology domain-containing proteins, implying that endoplasmic reticulum membrane shaping and peroxisome biogenesis may be coordinated.

  5. The results demonstrate an allosteric mechanism for the modulation of PEX19 function by farnesylation.

  6. that newly synthesized UBXD8 is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis

  7. suggest a novel regulatory mechanism for peroxisome biogenesis through the interaction between Pex19p and PLA/AT-3

  8. Thus within the cell, PEX3 is stabilized by PEX19 preventing PEX3 aggregation.

  9. PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway.

  10. PEX3-PEX19 interaction is crucial for de novo formation of peroxisomes in peroxisome-deficient cells.

  11. The Pex19p peptide contains a characteristic motif, consisting of the leucine triad (Leu18, Leu21, Leu22), and Phe29, which are critical for the Pex3p binding and peroxisome biogenesis.

  12. The crystal structure of the cytosolic domain of PEX3 in complex with a PEX19-derived peptide. PEX3 adopts a novel fold that is best described as a large helical bundle.

  13. data indicate a divided N-terminal and C-terminal structural arrangement in Pex19p, which is reminiscent of a similar division in the Pex5p receptor, to allow separation of cargo-targeting signal recognition and additional functions.

  14. a considerable functional diversity of the proteins encoded by two PEX19 splice variants and thereby provide first experimental evidence for specific biological functions of the different predicted domains of the PEX19 protein.

  15. PEX19 binds and stabilizes newly synthesized PMPs in the cytosol, binds to multiple PMP targeting signals (mPTSs), interacts with the hydrophobic domains of PMP targeting signals, and is essential for PMP targeting and import.

  16. Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET).

  17. Pex19p has a role in assembly of PTS-receptor docking complexes

  18. Results suggest that PEX3 plays a selective, essential, and direct role in class I peroxisomal membrane protein import as a docking factor for PEX19.

  19. human Pex19p domain architecture and activity

  20. analysis of the PEX19-binding site of human adrenoleukodystrophy protein

Profil protéine PEX19

Profil protéine

This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PEX19

  • Peroxin 19 (Pex19)
  • Peroxisomal farnesylated protein (Bm1_19905)
  • peroxisomal biogenesis factor 19 (PEX19)
  • peroxisomal biogenesis factor 19 (Pex19)
  • BEST:GH03076 Protéine
  • CG5325 Protéine
  • D1S2223E Protéine
  • DmelPex19 Protéine
  • Dmel\\CG5325 Protéine
  • HK33 Protéine
  • PBD12A Protéine
  • Peroxin-19 Protéine
  • PMP1 Protéine
  • PMPI Protéine
  • PxF Protéine
  • PXMP1 Protéine

Protein level used designations for PEX19

CG5325-PA , CG5325-PB , Pex19-PA , Pex19-PB , peroxin 19 , peroxisomal farnesylated protein , Peroxisomal farnesylated protein , 33 kDa housekeeping protein , housekeeping gene, 33kD , peroxin-19 , peroxisome biogenesis factor 19

34630 Drosophila melanogaster
6098885 Brugia malayi
5824 Homo sapiens
19298 Mus musculus
289233 Rattus norvegicus
521522 Bos taurus
100689302 Cricetulus griseus
100173241 Pongo abelii
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