Peroxisomal Biogenesis Factor 26 Protéines (PEX26)

PEX26 belongs to the peroxin-26 gene family. De plus, nous expédions PEX26 Anticorps (33) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PEX26 55670 Q7Z412
PEX26 74043 Q8BGI5
Rat PEX26 PEX26 297570  
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Showing 6 out of 8 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Humain His tag 100 μg 13 to 16 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days
Levure Cynomolgus His tag   1 mg 60 to 71 Days

PEX26 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine) ,

Plus protéines pour Peroxisomal Biogenesis Factor 26 (PEX26) partenaires d'interaction

Human Peroxisomal Biogenesis Factor 26 (PEX26) interaction partners

  1. Data support an alternative PEX14-dependent mechanism of peroxisomal membrane association for the splice variant, which lacks a transmembrane domain. Structure-function relationships of PEX26 isoforms explain an extended function in peroxisomal homeostasis and these findings may improve our understanding of the broad phenotype of PEX26-associated human disorders.

  2. In yeast, PEX26 follows the pathway that also ensures correct targeting of Pex15: PEX26 enters the endoplasmic reticulum (ER) in a GET-dependent and Pex19-independent manner.

  3. results suggested that peroxisome biogenesis requires Pex1p- and Pex6p-regulated dissociation of Pex14p from Pex26p

  4. PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway.

  5. degree of temperature sensitivity in pex26 cell lines is predictive of the clinical phenotype in patients with PEX26 deficiency

  6. PEX26 deficiency impairs peroxisomal import of both PTS1- and PTS2-targeted matrix proteins. It undergoes alternative splicing to produce several splice forms, including PEX26-delta, which rescues peroxisome biogenesis in PEX26-deficient cells.

  7. Pex26p functions in recruiting to peroxisomes the complexes of the AAA ATPase peroxins.

  8. We analyzed targeting of human PEX26. Its C-terminal-targeting signal contains two binding sites for PEX19 and we conclude C-terminal PEX19-binding sites mark tail-anchored proteins for delivery to peroxisomes.

  9. the relative fraction of disease-causing alleles that occur in the coding and splice junction sequences of PEX26 gene.

Profil protéine PEX26

Profil protéine

This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene.

Gene names and symbols associated with PEX26

  • peroxisomal biogenesis factor 26 (pex26)
  • peroxisomal biogenesis factor 26 (PEX26)
  • peroxisomal biogenesis factor 26 L homeolog (pex26.L)
  • peroxisomal biogenesis factor 26 (Pex26)
  • 4632428M11Rik Protéine
  • AI853212 Protéine
  • fk41g06 Protéine
  • PBD7A Protéine
  • PBD7B Protéine
  • PEX26M1T Protéine
  • Pex26pM1T Protéine
  • wu:fk41g06 Protéine
  • zgc:64014 Protéine

Protein level used designations for PEX26

peroxisome assembly protein 26 , peroxisome biogenesis factor 26 , peroxin-26 , peroxisome biogenesis disorder, complementation group 8 , peroxisome biogenesis disorder, complementation group A

334644 Danio rerio
418165 Gallus gallus
446477 Xenopus laevis
477743 Canis lupus familiaris
537878 Bos taurus
710470 Macaca mulatta
55670 Homo sapiens
74043 Mus musculus
297570 Rattus norvegicus
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