Peroxisomal Biogenesis Factor 3 Protéines (PEX3)

The product of PEX3 is involved in peroxisome biosynthesis and integrity. De plus, nous expédions PEX3 Anticorps (31) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PEX3 8504 P56589
PEX3 56535 Q9QXY9
Rat PEX3 PEX3 83519 Q9JJK4
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Top PEX3 Protéines sur anticorps-enligne.fr

Showing 7 out of 8 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,227.64
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
$7,294.44
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,122.60
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,227.64
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails
Levure Yeast His tag   1 mg 60 to 71 Days
$3,113.00
Détails
Levure Yeast His tag   1 mg 60 to 71 Days
$3,175.33
Détails

PEX3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine) ,
,

Plus protéines pour Peroxisomal Biogenesis Factor 3 (PEX3) partenaires d'interaction

Human Peroxisomal Biogenesis Factor 3 (PEX3) interaction partners

  1. studies indicate that Pex3 and Pex19 can also facilitate sorting of certain membrane proteins to other cellular organelles, including the endoplasmic reticulum, lipid droplets, and mitochondria

  2. BAG1, CHMP2B, PEX3, and WIPI1 confirmed a strong differential gene expression, in 355 melanoma samples.

  3. Thus, PEX19 and PEX3 peroxisome biogenesis factors provide an alternative posttranslational route for membrane insertion of the reticulon homology domain-containing proteins, implying that endoplasmic reticulum membrane shaping and peroxisome biogenesis may be coordinated.

  4. that newly synthesized UBXD8 is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis

  5. This insertion of PEX3 into the ER is physiologically relevant.

  6. PEX16 mediates the peroxisomal trafficking of two distinct peroxisomal membrane proteins, PEX3 and PMP34, via the endoplasmic reticulum

  7. Thus within the cell, PEX3 is stabilized by PEX19 preventing PEX3 aggregation.

  8. Mutations in the PEX19-binding domain of PEX3 reduce the affinity for PEX19 and destabilize PEX3.

  9. The Pex19p peptide contains a characteristic motif, consisting of the leucine triad (Leu18, Leu21, Leu22), and Phe29, which are critical for the Pex3p binding and peroxisome biogenesis.

  10. The crystal structure of the cytosolic domain of PEX3 in complex with a PEX19-derived peptide. PEX3 adopts a novel fold that is best described as a large helical bundle.

  11. Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET).

  12. Results suggest that PEX3 plays a selective, essential, and direct role in class I peroxisomal membrane protein import as a docking factor for PEX19.

  13. Data suggest that Pex19p probably functions as a chaperone for membrane proteins and transports them to peroxisomes by anchoring to Pex3p using residues 12-73 and 40-131.

  14. either one or two tryptophan residues of Pex3p (Trp-104 and Trp-224) are directly involved in binding to Pex19p.

  15. Pex3p follows the ER-to-peroxisomal route; Pex3p requires Pex16p for ER location but is dispensable for the ER location of Pex16p

  16. The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids.

Profil protéine PEX3

Profil protéine

The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS).

Gene names and symbols associated with PEX3

  • peroxisomal biogenesis factor 3 (LOC692959)
  • peroxisomal biogenesis factor 3 (CpipJ_CPIJ013204)
  • peroxin 3 (pex3)
  • peroxisomal biogenesis factor 3 (PEX3)
  • peroxisomal biogenesis factor 3 (pex3)
  • peroxisomal biogenesis factor 3 L homeolog (pex3.L)
  • peroxisomal biogenesis factor 3 (Pex3)
  • 1700014F15Rik Protéine
  • 2810027F19Rik Protéine
  • 2900010N04Rik Protéine
  • DDBDRAFT_0204086 Protéine
  • DDBDRAFT_0238047 Protéine
  • DDB_0204086 Protéine
  • DDB_0238047 Protéine
  • PBD10A Protéine
  • Peroxin-3 Protéine
  • TRG18 Protéine
  • zgc:56313 Protéine

Protein level used designations for PEX3

peroxisomal biogenesis factor 3 , transmembrane protein , peroxin-3 , peroxisomal assembly protein PEX3 , transformation-related protein 18 , Peroxisomal assembly protein PEX3 , peroxisomal assembly protein 3 , Peroxisomal biogenesis factor 3

GENE ID SPECIES
692959 Bombyx mori
6046074 Culex quinquefasciatus
8622947 Dictyostelium discoideum AX4
100230879 Taeniopygia guttata
100582200 Nomascus leucogenys
393197 Danio rerio
444067 Xenopus laevis
421669 Gallus gallus
8504 Homo sapiens
484015 Canis lupus familiaris
515730 Bos taurus
56535 Mus musculus
83519 Rattus norvegicus
100760471 Cricetulus griseus
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