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Negative regulator of hepatic phosphatidylinositol 3- kinase (PI3K) activity (By similarity). De plus, nous expédions PIK3IP1 Protéines (10) et PIK3IP1 Kits (1) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal PIK3IP1 Primary Antibody pour WB - ABIN2784094
Podbielski, Rodriguez, Zhu, Worley, Fontaine, Connolly: Aortoesophageal fistula secondary to reflux esophagitis. dans Digestive surgery 2007
Show all 2 Pubmed References
Findings indicate that colon cancer associated transcript 1 (non-protein coding) (CCAT1) was upregulated in osteosarcoma tissues and cells, and was involved in the proliferation and migration of osteosarcoma via regulating miR-148a/phosphatidyl inositol 3-kinase interacting protein 1 (PIK3IP1) signal pathway.
These results suggest that the novel PI3K regulator PIK3IP1 plays an inhibitory role in T-cell activation.
PIK3IP1-v1 is a novel splicing isoform of PIK3IP1. Both of them are located on cell membrane and can induce cell apoptosis.
PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Suggested that PIK3IP1 is a new type of PI3K regulator.
PIK3IP1 is an important regulator of PI3K in vivo, and its dysregulation can contribute to liver carcinogenesis
PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt.
Mechanistically, phosphotidyl inositol 3'kinase interacting protein 1 (PIK3IP1), a negative regulator of PI3K, was identified as a novel target of miR-let-7. A conserved hypoxia-responsive Lin28-miR-let-7-Pik3ip1 regulatory axis is specific to cardiac myocytes and promotes apoptosis during myocardial ischemic injury.
Our results identified PIK3IP1 as a novel target of ARID1A and PGR in the murine uterus.
Pik3ip1 plays a compensatory negative role for physiologic cardiac hypertrophy. Collectively, our results elucidate the mechanisms for the roles of Pik3ip1 in PI3K/AKT signaling pathway
Data suggest that that neural progenitors are particularly vulnerable to FOXO3-induced apoptosis, which is mediated by PIK3IP1, a negative PI3 kinase regulator.
Negative regulator of hepatic phosphatidylinositol 3- kinase (PI3K) activity (By similarity).
kringle domain-containing protein HGFL
, phosphoinositide-3-kinase-interacting protein 1
, calcineurin-regulated kringle domain protein
, calcineurin-regulated kringle domain-containing protein
, HGFL protein