Profil protéine

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Gene names and symbols associated with PTTG1

• pituitary tumor-transforming 1 (PTTG1) anticorps
• pituitary tumor-transforming gene 1 (Pttg1) anticorps
• pituitary tumor-transforming 1 (Pttg1) anticorps
• securin, sister chromatid separation inhibitor (cut2) anticorps

• AW555095 anticorps
• C87862 anticorps
• EAP1 anticorps
• HPTTG anticorps
• Protein Cut2 anticorps
• Afficher tous les alias de synonymes
• Pttg anticorps
• PTTG1 anticorps
• Pttg3 anticorps
• Securin anticorps
• TUTR1 anticorps

Protein level used designations for PTTG1

ESP1-associated protein 1 , pituitary tumor-transforming gene 1 protein , securin , tumor-transforming protein 1 , pituitary tumor-transforming protein 1 , pituitary tumor-transforming 1 , Pituitary tumor transforming , Pituitary tumor-transforming gene 1 protein , Cell untimely torn protein 2