anti-Pituitary Tumor-Transforming 1 (PTTG1) Anticorps

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. De plus, nous expédions PTTG1 Protéines (19) et PTTG1 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
PTTG1 9232 O95997
PTTG1 30939 Q9CQJ7
PTTG1 64193 P97613
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Top anti-PTTG1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 106 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué WB Anti-Securin antibody, Western blotting All lanes: Anti PTTG1  at 0.5ug/ml Lane 1: HELA Whole Cell Lysate at 40ug Lane 2: MCF-7 Whole Cell Lysate at 40ug Lane 3: SKOV Whole Cell Lysate at 40ug Lane 4: A375 Whole Cell Lysate at 40ug Predicted bind size: 22KD Observed bind size: 22KD 100 μg 4 to 6 Days
$240.00
Détails
Humain Lapin Inconjugué IHC, ELISA, WB Western blot analysis of extracts from RAW264.7 cells, using PTTG Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PTTG Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué IF, ELISA, WB Western blot analysis of extracts from HepG2/Jurkat/293 cells, using PTTG1 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HuvEc cells, using PTTG1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, IHC, WB ABIN6274144 staining HepG2 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. ABIN6274144 staining MCF7 cells by ICC/IF. Cells were fixed with PFA and permeabilized in 0.1% saponin prior to blocking in 10% serum for 45 minutes at 37°C. The primary antibody was diluted 1/200 and incubated with the sample for 1 hour at 37°C. A Alexa Fluor 594 conjugated goat polyclonal to rabbit IgG (H+L), diluted 1/600 was used as secondary antibody. 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, WB Western blot analysis on Jurkat and K562 cell lysate using PTTG1 Antibody,The lane on the left is treated with the antigen-specific peptide. Western blot analysis of extracts from various samples, using PTTG1 Antibody. Lane 1: 293 treated with blocking peptide. Lane 2: 293; Lane 3: hela; 100 μL 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué WB Western blot analysis of extract of various cells, using PTTG1 antibody. Immunohistochemistry of paraffin-embedded human lung cancer using PTTG1 antibody at dilution of 1:100 (40x lens). 100 μL 11 to 13 Days
$366.77
Détails
Humain Chèvre Inconjugué IHC, IHC (p) Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$484.00
Détails
Humain Souris Inconjugué IF, IHC (p), IP, WB 0.1 mg 6 to 8 Days
$357.50
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, IHC, WB Western blot analysis of extracts from RAW264.7 cells, using PTTG antibody. ABIN6274290 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Détails
Humain Souris Inconjugué ELISA, WB 100 μg 11 to 14 Days
$551.83
Détails

anti-PTTG1 Anticorps mieux référencés

  1. Human Polyclonal PTTG1 Primary Antibody pour WB - ABIN3042643 : Zhang, Liu, Xu, Huang, Tan, Sun, Lu: Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in oral squamous cell carcinoma (OSCC) and promotes migration, invasion and epithelial-mesenchymal transition (EMT) in SCC15 cells. dans Tumour biology 2014 (PubMed)

  2. Human Monoclonal PTTG1 Primary Antibody pour IHC (p), IHC - ABIN153436 : Hong, Joo, Park, Seo, Kim, Shin, Cheong, Lee, Kim: Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis. dans Annals of neurology 2019 (PubMed)

Plus d’anticorps contre PTTG1 partenaires d’interaction

Human Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. PTTG and PBF interact in head and neck squamous cell carcinoma to reduce p53 stability and function

  2. Higher levels of PTTG1 were observed in hepatocellular carcinoma (HCC) tumor tissues. Its expression is regulated by PTTG3P in HCC.

  3. Cancer-associated fibroblasts (CAFs) could induce pituitary tumor transforming gene (PTTG) over-expression and increase endometrial cancer (EC) cell invasion and migration in vitro.

  4. We found that PTTG overexpression in pituitary tumor cells is explained by its protein stabilization, is regulated by RSUME and accounts for PTTG tumor abundance and pathogenic action. There is no evidence so far that this mechanism operates in normal cells. This finding puts in a central role the protein stabilization-overexpression of proto-oncogenes as major regulators of cellular dysfunction.

  5. High PTTG1 expression was associated with Adrenocortical Carcinoma.

  6. the short form of securin does not influence the expression of MYC transcriptional targets, such as TP53 and IL-8.

  7. Data strongly indicated that PTTG1 is a target gene of miR186 in osteosarcoma (OS) cells and is involved in miR186mediated suppressive effects of OS cells.

  8. Results show that PTTG1 oncoprotein overexpression may modulate cell proliferation-related regulators in myeloid leukemia.

  9. In ACTH-secreting pituitary tumors, IHC staining showed strong cytoplasmic and moderate nucleic PTTG immunoreactivity in 22 of 28 nonrecurrent tumors and in 21 of 27 recurrent tumors but no staining in the 2 normal pituitaries. PTTG was significantly increased in both the nonrecurrent and recurrent groups compared with normal pituitary glands, but there was no difference between the nonrecurrent and recurrent groups.

  10. Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.

  11. PTTG-1 oexpression in meningiomas were correlated with tumor grade and proliferation rate.

  12. Results found that PTTG1 expression was significantly increased in androgen-independent prostate cancer cells and, elucidates that interleukin-6/STAT3 activation can increase PTTG1 expression and, consequently, promote the resistance to androgen deprivation therapy in castration-resistant prostate cancer by inducing EMT and increasing the cancer stem cell population.

  13. we confirmed the oncogenic function of PTTG1 in BC and demonstrated that PTTG1 is a target of miR-146a-3p.

  14. PTTG1 is an independent prognostic factor and acts as an oncogene in colorectal cancer

  15. High PTTG1 expression is associated with aggressive meningiomas.

  16. These results indicate PTTG1 may be a valuable biomarker in ovarian cancer to predict sensitivity to saracatinib, and could form the basis of a targeted prospective saracatinib trial for ovarian cancer.

  17. A relatively stable genome in retinoblastoma tumor cells is maintained by TRb1 and TRb2-mediated PTTG1 inhibition, counteracting Rb-deficiency-related genomic instability.

  18. Findings indicate that PBF and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome.

  19. PTTG-mediated FGF2 upregulation is associated with more aggressive tumor features in patients with acromegaly. Also, locally produced estrogen through aromatization might have a role in this phenomenon.

  20. All these suggest that the MAP3K M1P site is a potential interacting partner of MAP3K SH3 domain, which may mediate the intermolecular recognition between hPTTG1 and MAP3K.

Pig (Porcine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. PTTG1 is a new candidate maternal effect gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis

Mouse (Murine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. The findings show that maternal aging compromises the oocyte SAC-APC/C axis leading to a decrease in securin that ultimately causes sister chromatid cohesion loss.

  2. Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.

  3. High PTTG1 expression is associated with pituitary tumor development.

  4. PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.

  5. RasGrf1 is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.

  6. these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.

  7. Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis

  8. PBF is the first protein to interact with the critical TH transporter MCT8 and modulate its function in vivo

  9. CSN3 and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 and Securin via APC/C.

  10. The genetically deleting Tff3 in mice altered down-regulated Pttg1 and up-regulated serpina3n expression, indicating a potential role of these factors during the development of presbyacusis.

  11. data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function

  12. Pituitary tumor transforming gene 1 (PTTG1), an oncogene, was the most up-regulated transcript in KLF6+/- liver. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6.

  13. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes.

  14. homologue disjunction in mouse oocytes is dependent on proteolysis of the separase inhibitor securin and cyclin B1

  15. Physiological functions of PTTG are revealed by PTTG-null mice who exhibit a variety of cell growth abnormalities including diabetes mellitus secondary to defective beta-cell proliferation. Review.

  16. Securin phosphorylation act redundantly to prevent sister chromatid separation.

  17. results suggest that Rae1 and Nup98 are temporal regulators of APC(Cdh1) that maintain euploidy by preventing unscheduled degradation of securin

  18. results suggest that the proteolysis of securin is dependent on ubiquitin-proteasome pathway and is necessary for the degradation of Rec8 during meiotic metaphase-to-anaphase transitions in oocytes

  19. PTTG1 and its binding protein PTTG binding factor are expressed in pituitary FS TtT/GF cells.

  20. PTTG1, an oncogene, is regulated by the liganded thyroid hormone receptor beta

PTTG1 profil antigène

Profil protéine

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Gene names and symbols associated with PTTG1

  • pituitary tumor-transforming 1 (PTTG1) anticorps
  • pituitary tumor-transforming gene 1 (Pttg1) anticorps
  • pituitary tumor-transforming 1 (Pttg1) anticorps
  • securin, sister chromatid separation inhibitor (cut2) anticorps
  • AW555095 anticorps
  • C87862 anticorps
  • EAP1 anticorps
  • HPTTG anticorps
  • Protein Cut2 anticorps
  • Pttg anticorps
  • PTTG1 anticorps
  • Pttg3 anticorps
  • Securin anticorps
  • TUTR1 anticorps

Protein level used designations for PTTG1

ESP1-associated protein 1 , pituitary tumor-transforming gene 1 protein , securin , tumor-transforming protein 1 , pituitary tumor-transforming protein 1 , pituitary tumor-transforming 1 , Pituitary tumor transforming , Pituitary tumor-transforming gene 1 protein , Cell untimely torn protein 2

GENE ID SPECIES
9232 Homo sapiens
397015 Sus scrofa
416158 Gallus gallus
479307 Canis lupus familiaris
508043 Bos taurus
696143 Macaca mulatta
30939 Mus musculus
64193 Rattus norvegicus
462238 Pan troglodytes
100848911 Bos taurus
2539641 Schizosaccharomyces pombe 972h-
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