Piwi-Like 1 (Drosophila) Protéines (PIWIL1)

PIWIL1 encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. De plus, nous expédions Piwi-Like 1 (Drosophila) Anticorps (101) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PIWIL1 9271 Q96J94
PIWIL1 57749 Q9JMB7
Rat PIWIL1 PIWIL1 363912  
Comment commander chez anticorps-enligne
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top Piwi-Like 1 (Drosophila) Protéines sur anticorps-enligne.fr

Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails

PIWIL1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Piwi-Like 1 (Drosophila) (PIWIL1) partenaires d'interaction

Medaka Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. piwi plays a generally conserved role in germ cell development in Oryzias latipes.

  2. These results suggest that both Olpiwi1 and Olpiwi2 are germ cell specific, and may play important roles in germ cell development and gametogenesis in this model species.

Zebrafish Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. the zebrafish homologue of the Drosophila piwi: co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults (ziwi protein).

  2. Tdrd1 acts as a molecular scaffold for Ziwi.

  3. Promoter activity of a 4.8-kb sequence isolated from the 5' end of the zebrafish germ cell-specific ziwi gene is sufficient to drive gene expression in all germ cells with stage-specific differences in expression levels.

  4. study demonstrated that zebrafish Piwi, Ziwi is expressed in gonad of both sexes and is a component of a structure called nuage; loss of Ziwi function results in a progressive loss of germ cells due to apoptosis during larval development

  5. Ziwi and Zili bind piRNAs of opposite polarity

Pig (Porcine) Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. Data show that Piwil1 and Piwil2 are mapped together onto the chromosome 14, at the q14 and q11 respectively.

Human Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. Study data in human gastric cancer cell line AGP01 reinforce the idea that PIWIL1 plays a crucial role in the signaling pathway of gastric cancer, regulating several genes involved in migration and invasion processes.

  2. piRNAs may function in gene silencing and gene modification upstream or downstream of oncogenes in cancer cell lines or cancer tissues. In addition to piRNAs, PIWI proteins can be used as biomarkers for prognosis, diagnosis and clinical evaluation and may be factors in cancer metastasis.

  3. Unlike most other Tudor domains TDRD2 preferentially recognizes an unmethylated arginine-rich sequence from PIWIL1.

  4. HENMT1 and PIWI proteins are expressed in a germ-cell-specific manner and required for transposon control.

  5. A statistically significantly higher level of PIWIL1 and PIWIL2 was found in IDC compared to mastopathy samples (p

  6. Expression of PIWIL1 in the cancer tissue was higher than that in the corresponding adjacent tissue. High PIWIL1 expression suggests a poor prognosis for colorectal cancer patients.

  7. PIWIL3 and PIWIL4 genes showed prognostic relevance. 306 gene targets exhibited reciprocal relationship with piRNA expression

  8. Findings identify Piwi as a factor in human infertility and reveal its role in regulating the histone-to-protamine exchange during spermiogenesis.

  9. In blood serum, piR-823 is up-regulated, but with unsatisfactory analytical performance. Preliminary data indicate the promising diagnostic utility of urinary piR-823 in patients with RCC

  10. Overexpression of Hiwi significantly suppressed cell proliferation and cell migration and induced apoptosis in K562 cells.

  11. Hiwi upregulation enhanced chemosensitivity of Chronic Myeloid Leukemia cells to daunomycin, suppressed cell proliferation and promoted apoptosis.

  12. HIWI promotes the activity of breast cancer cells while depression of HIWI may induce apoptosis of breast cancer cells.

  13. Our study reveals a novel mechanism for PIWIL1 in tumorigenesis.

  14. PIWIL1 expression emerged as an independent prognostic marker in non-small cell lung cancer.

  15. Among patients with high let-7a expression, those with medium HIWI had an increased risk of death compared to those with low HIWI (HR = 2.62, 95% CI: 1.30-5.30).

  16. results suggested that Piwil1 caused the loss of PTEN expression through DNMT1-mediated PTEN hypermethylation

  17. Results show that HIWI is highly expressed in high-grade squamous intraepithelial lesions and cervical cancer tissues suggesting its participation in the carcinogenesis of cervical cancer.

  18. Our results indicate a reciprocal regulation between HIWI, HILI and some CSCs markers in colorectal cancer

  19. Evidence of an active PIWI-interacting small non-coding RNAs pathway in BC suggests that these small non-coding RNAs do exert transcriptional and post-transcriptional gene regulatory actions also in cancer cells.

  20. Hiwi downregulation mediated by shRNA reduce the proliferation and migration of HCC cells.

Cow (Bovine) Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. full-length transcript present in testes, not in oocytes or early embryos; two shorter isoforms, PL1-10 and PL1-13, expressed in oocytes and early embryos

Mouse (Murine) Piwi-Like 1 (Drosophila) (PIWIL1) interaction partners

  1. the testis-expressed transcription factor, Tbx1, and the piRNA regulator of gamete development, Piwil1, were both found to be targeted for translational repression by MSI2.

  2. Unlike most other Tudor domains TDRD2 preferentially recognizes an unmethylated arginine-rich sequence from PIWIL1.

  3. MIWI (or PIWIL1) depletion had a smaller effect. In oocytes lacking PLD6 (or ZUCCHINI or MITOPLD), a mitochondrial nuclease/phospholipase involved in piRNA biogenesis in male germ cells, the piRNA level was decreased to 50% compared to wild-type.

  4. Stem cell protein Piwil1 plays an important role in regulating stem-like properties of endometrial cancer cells.

  5. piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.

  6. PIWIL1 regulates neuronal polarization and radial migration partly via modulating the expression of microtubule-associated proteins.

  7. Results show that HIWI is highly expressed in high-grade squamous intraepithelial lesions and cervical cancer tissues suggesting its participation in the carcinogenesis of cervical cancer.

  8. We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.

  9. Mice with a global deletion of all three piwi genes, Miwi, Mili, and Miwi2, are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.

  10. Miwi protein might be an important functional protein in murine folliculogenesis

  11. The in vitro studies show estrogen can downregulate the expression of miwi and mili.

  12. characterize the genome-wide target RNA repertoire of Mili (Piwil2) and Miwi (Piwil1), two Piwi proteins expressed in postnatal testis

  13. This work identifies an epigenetic regulation mechanism for the spatio-temporal expression of mouse Miwi during spermatogenesis.

  14. Co-immunoprecipitation assay in vivo and in vitro confirmed MIWI is a bona fide partner of STK31 in mice testes.

  15. Miwi is a small RNA-guided RNase (slicer) that requires extensive complementarity for target cleavage in vitro

  16. PIWI proteins function in meiosis during spermatogenesis.

  17. Mouse homologue of the Piwi Protein recognizes the 2'-O-Methylated 3'-End of piRNA by the PAZ Domain.

  18. MIWI, a murine Piwi protein, binds a previously uncharacterized class of approximately 29-30-nucleotide RNAs that are highly abundant in testes

  19. A functional interplay between KIF17b and MIWI might be needed for the loading of haploid RNAs in the chromatoid body.

  20. Piwi-interacting RNAs are fully modified by 2'-O-methylation at their 3' termini: this observation may provide a clue to the biogenesis and function of piRNAs in spermatogenesis

Profil protéine Piwi-Like 1 (Drosophila) (PIWIL1)

Profil protéine

This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PIWIL1

  • piwi like RNA-mediated gene silencing 1 (PIWIL1)
  • PIWI-like protein 1 (Tb10.70.5520)
  • putative PIWI-like protein 1 (LINJ_21_0470)
  • putative argonaut-like protein (LBRM_21_0470)
  • piwi like RNA-mediated gene silencing 1 (piwil1)
  • piwi-like RNA-mediated gene silencing 1 (piwil1)
  • piwi-like RNA-mediated gene silencing 1 (Piwil1)
  • HIWI Protéine
  • MIWI Protéine
  • PIWI Protéine
  • ziwi Protéine

Protein level used designations for PIWIL1

piwi-like 1 (Drosophila) , PIWI-like protein 1 , argonaut-like protein , piwi-like protein 1 , piwi homolog , piwi-like 1 , piwi-like protein 1-like , piwi like homolog 1 , piwi-like homolog 1

GENE ID SPECIES
452369 Pan troglodytes
3662385 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5068770 Leishmania infantum JPCM5
5415312 Leishmania braziliensis MHOM/BR/75/M2904
100301587 Oryzias latipes
368200 Danio rerio
477440 Canis lupus familiaris
100499508 Sus scrofa
416804 Gallus gallus
9271 Homo sapiens
537833 Bos taurus
57749 Mus musculus
363912 Rattus norvegicus
Fournisseurs de qualité sélectionnés pour Piwi-Like 1 (Drosophila) Protéines (PIWIL1)
Avez-vous cherché autre chose?