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PIWIL1 encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. De plus, nous expédions Piwi-Like 1 (Drosophila) Anticorps (82) et et beaucoup plus de produits pour cette protéine.
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piwi plays a generally conserved role in germ cell development in Oryzias latipes.
the zebrafish homologue of the Drosophila piwi: co-localization with vasa (Montrer DDX4 Protéines) at the embryonic genital ridge and gonad-specific expression in the adults (ziwi protein).
Tdrd1 (Montrer TDRD1 Protéines) acts as a molecular scaffold for Ziwi.
Promoter activity of a 4.8-kb sequence isolated from the 5' end of the zebrafish germ cell-specific ziwi gene is sufficient to drive gene expression in all germ cells with stage-specific differences in expression levels.
study demonstrated that zebrafish Piwi, Ziwi is expressed in gonad of both sexes and is a component of a structure called nuage; loss of Ziwi function results in a progressive loss of germ cells due to apoptosis during larval development
Ziwi and Zili bind piRNAs of opposite polarity
Data show that Piwil1 and Piwil2 are mapped together onto the chromosome 14, at the q14 and q11 respectively.
Unlike most other Tudor domains TDRD2 preferentially recognizes an unmethylated arginine-rich sequence from PIWIL1.
HENMT1 and PIWI proteins are expressed in a germ-cell-specific manner and required for transposon control.
A statistically significantly higher level of PIWIL1 and PIWIL2 was found in IDC compared to mastopathy samples (p=0.0001). Increased expression of PIWIL1 was correlated with increased PIWIL2 expression in breast cancer tissue.
Expression of PIWIL1 in the cancer tissue was higher than that in the corresponding adjacent tissue. High PIWIL1 expression suggests a poor prognosis for colorectal cancer patients.
PIWIL3 and PIWIL4 (Montrer PIWIL4 Protéines) genes showed prognostic relevance. 306 gene targets exhibited reciprocal relationship with piRNA expression
Findings identify Piwi as a factor in human infertility and reveal its role in regulating the histone-to-protamine exchange during spermiogenesis.
In blood serum, piR (Montrer PIR Protéines)-823 is up-regulated, but with unsatisfactory analytical performance. Preliminary data indicate the promising diagnostic utility of urinary piR (Montrer PIR Protéines)-823 in patients with RCC (Montrer XRCC1 Protéines)
Overexpression of Hiwi significantly suppressed cell proliferation and cell migration and induced apoptosis in K562 cells.
Hiwi upregulation enhanced chemosensitivity of Chronic Myeloid Leukemia (Montrer BCL11A Protéines) cells to daunomycin, suppressed cell proliferation and promoted apoptosis.
HIWI promotes the activity of breast cancer cells while depression of HIWI may induce apoptosis of breast cancer cells.
full-length transcript present in testes, not in oocytes or early embryos; two shorter isoforms, PL1 (Montrer PRL3D1 Protéines)-10 and PL1 (Montrer PRL3D1 Protéines)-13, expressed in oocytes and early embryos
MIWI (or PIWIL1) depletion had a smaller effect. In oocytes lacking PLD6 (Montrer PLD6 Protéines) (or ZUCCHINI or MITOPLD (Montrer PLD6 Protéines)), a mitochondrial nuclease (Montrer DCLRE1C Protéines)/phospholipase involved in piRNA biogenesis in male germ cells, the piRNA level was decreased to 50% compared to wild-type.
Stem cell protein (Montrer TAL1 Protéines) Piwil1 plays an important role in regulating stem-like properties of endometrial cancer cells.
piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.
PIWIL1 regulates neuronal polarization and radial migration partly via modulating the expression of microtubule-associated proteins.
Results show that HIWI is highly expressed in high-grade squamous intraepithelial lesions and cervical cancer tissues suggesting its participation in the carcinogenesis of cervical cancer.
We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.
Mice with a global deletion of all three piwi genes, Miwi, Mili, and Miwi2 (Montrer PIWIL4 Protéines), are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.
Miwi protein might be an important functional protein in murine folliculogenesis
The in vitro studies show estrogen can downregulate the expression of miwi and mili.
This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
piwi-like 1 (Drosophila)
, PIWI-like protein 1
, argonaut-like protein
, piwi-like protein 1
, piwi homolog
, piwi-like 1
, piwi-like protein 1-like
, piwi like homolog 1
, piwi-like homolog 1