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PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008].. De plus, nous expédions PIWIL4 Anticorps (62) et beaucoup plus de produits pour cette protéine.
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Results revealed that Piwil4 exhibits lower expression in the cell nucleus than in the cytoplasm. Along with nuclear location of PIWIL2, PIWIL4 expression is associated with worse prognosis of hepatocellular carcinoma.
HIWI2 is aberrantly expressed in cells of the Retinoblastoma (RB) line (Y79) and silencing of HIWI2 downregulates OTX2 (Montrer OTX2 Protéines), suggesting that HIWI2 might affects cell cycle and plays a role in the progression of RB.
data delineate MIWI2-dependent functions outside of the germline and demonstrate the presence of distinct subsets of airway multiciliated cells that can be discriminated by MIWI2 expression.
PIWIL2 and PIWIL4 genes expression in synovial fibroblasts of the rheumatoid arthritis patients.PIWIL4 does not regulate methylation or expression of LINE-1.
MiR (Montrer MLXIP Protéines)-384 functioned as tumor suppressor by decreasing PIWIL4 in glioma cell lines.
study demonstrates the presence of PIWI (Montrer PIWIL1 Protéines)-like proteins in somatic cells and the possible role of HIWI2 in preserving the functional integrity of epithelial cells probably by modulating the phosphorylation status of Akt (Montrer AKT1 Protéines).
PIWIL4 is highly expressed in both breast cancer tissues and the cytoplasm of MDA-MB-231 cells derived from breast cancer. Reducing PIWIL4 expression drastically impairs the migration ability of MDA-MB-231 cells, significantly increases their apoptosis, and mildly affects their proliferation.
Results show that three CpG loci within FYN (Montrer FYN Protéines) were hypermethylated in obese individuals, while obesity was associated with lower methylation of CpG loci within PIWIL4 and TAOK3 (Montrer TAOK3 Protéines).
study to evaluate frequency of PIWIL4 genetic variants in order to better define the relationship between PIWIL4 SNPs and defective spermatogenesis and specific spermatogenic disorders; results suggest genetic and epigenetic alterations that affect the PIWI pathway contribute to unsuccessful sperm production
Data suggest that MIWI2 and MIWI2-associated piRNAs have functions beyond TE suppression.
MIWI2 functions as an effector of de novo DNA methylation (Montrer HELLS Protéines) of the retrotransposon.
Miwi2 deficiency had only a minor impact on piRNA biogenesis. Miwi2-knockout mice indicated overexpression of several LINE1 TE families.
piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.
MIWI2 is not solely necessary for hematopoiesis within the normal life span of a mouse.
Mice with a global deletion of all three piwi (Montrer PIWIL1 Protéines) genes, Miwi (Montrer PIWIL1 Protéines), Mili, and Miwi2, are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.
Icariin induced a decrease in piwil4 protein expression and piwil4 silencing significantly enhanced the cytotoxic effects of icariin in MLTC-1 cells.
Results identify TDRD9 as a functional partner of MIWI2 and indicate that the tudor-piwi association is a conserved feature, while two separate axes, TDRD9-MIWI2 and TDRD1-MILI, cooperate in the piwi-small RNA pathway in the mouse male germline.
Data strongly suggest that MILI and MIWI2 play essential roles in establishing de novo DNA methylation (Montrer HELLS Protéines) of retrotransposons in fetal male germ cells.
purified the three murine Piwi (Montrer PIWIL1 Protéines) family proteins, MILI, MIWI (Montrer PIWIL1 Protéines), and MIWI2, from mouse germ cells and characterized their interacting protein partners
PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003
, piwi-like protein 4
, piwi-like homolog 4