Piwi-Like 4 (Drosophila) Protéines (PIWIL4)

PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008].. De plus, nous expédions PIWIL4 Anticorps (62) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PIWIL4 143689 Q7Z3Z4
PIWIL4 330890 Q8CGT6
Rat PIWIL4 PIWIL4 689972  
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
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PIWIL4 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Piwi-Like 4 (Drosophila) (PIWIL4) partenaires d'interaction

Human Piwi-Like 4 (Drosophila) (PIWIL4) interaction partners

  1. these findings revealed that Piwil4 is a novel regulator of ER signaling that could be targeted to inhibit breast cancer growth and migration.

  2. Results revealed that Piwil4 exhibits lower expression in the cell nucleus than in the cytoplasm. Along with nuclear location of PIWIL2, PIWIL4 expression is associated with worse prognosis of hepatocellular carcinoma.

  3. HIWI2 is aberrantly expressed in cells of the Retinoblastoma (RB) line (Y79) and silencing of HIWI2 downregulates OTX2, suggesting that HIWI2 might affects cell cycle and plays a role in the progression of RB.

  4. data delineate MIWI2-dependent functions outside of the germline and demonstrate the presence of distinct subsets of airway multiciliated cells that can be discriminated by MIWI2 expression.

  5. PIWIL2 and PIWIL4 genes expression in synovial fibroblasts of the rheumatoid arthritis patients.PIWIL4 does not regulate methylation or expression of LINE-1.

  6. MiR-384 functioned as tumor suppressor by decreasing PIWIL4 in glioma cell lines.

  7. study demonstrates the presence of PIWI-like proteins in somatic cells and the possible role of HIWI2 in preserving the functional integrity of epithelial cells probably by modulating the phosphorylation status of Akt.

  8. PIWIL4 is highly expressed in both breast cancer tissues and the cytoplasm of MDA-MB-231 cells derived from breast cancer. Reducing PIWIL4 expression drastically impairs the migration ability of MDA-MB-231 cells, significantly increases their apoptosis, and mildly affects their proliferation.

  9. Results show that three CpG loci within FYN were hypermethylated in obese individuals, while obesity was associated with lower methylation of CpG loci within PIWIL4 and TAOK3.

  10. study to evaluate frequency of PIWIL4 genetic variants in order to better define the relationship between PIWIL4 SNPs and defective spermatogenesis and specific spermatogenic disorders; results suggest genetic and epigenetic alterations that affect the PIWI pathway contribute to unsuccessful sperm production

  11. Data suggest that MIWI2 and MIWI2-associated piRNAs have functions beyond TE suppression.

  12. Immunoprecipitation of Hiwi2 from MDAMB231 cancer cells enriches for piRNAs that are predominantly derived from processed tRNAs and expressed genes.

  13. associations were determined between the Piwi-like family member expression levels and clinicopathological parameters of ccRCC, suggesting a potential role for these genes/proteins in ccRCC diagnostics and tumorigenesis

  14. we identified a significant association between the expression of Piwi-like 2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients.

  15. PIWIL4 might play an oncogenic role in cervical cancer

  16. An SNP in the 3'untranslated region of HIWI2 and a non-synonymous SNP in HIWI3 were significantly associated with an altered risk of oligozoospermia.

  17. EIF2C2-4 and PIWIL4 appear increased in advanced tumors with distant metastasis, suggesting they may promote tumor invasion

  18. PIWIL4 plays important roles in the chromatin-modifying pathway in human somatic cells

Mouse (Murine) Piwi-Like 4 (Drosophila) (PIWIL4) interaction partners

  1. MIWI2 functions as an effector of de novo DNA methylation of the retrotransposon.

  2. data delineate MIWI2-dependent functions outside of the germline and demonstrate the presence of distinct subsets of airway multiciliated cells that can be discriminated by MIWI2 expression.

  3. Miwi2 deficiency had only a minor impact on piRNA biogenesis. Miwi2-knockout mice indicated overexpression of several LINE1 TE families.

  4. piRNA biogenesis triggered by PIWI slicing, and promoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.

  5. MIWI2 is not solely necessary for hematopoiesis within the normal life span of a mouse.

  6. Mice with a global deletion of all three piwi genes, Miwi, Mili, and Miwi2, are able to maintain long-term hematopoiesis with no observable effect on the homeostatic hematopoietic stem cells compartment in adult mice.

  7. Icariin induced a decrease in piwil4 protein expression and piwil4 silencing significantly enhanced the cytotoxic effects of icariin in MLTC-1 cells.

  8. Results identify TDRD9 as a functional partner of MIWI2 and indicate that the tudor-piwi association is a conserved feature, while two separate axes, TDRD9-MIWI2 and TDRD1-MILI, cooperate in the piwi-small RNA pathway in the mouse male germline.

  9. Data strongly suggest that MILI and MIWI2 play essential roles in establishing de novo DNA methylation of retrotransposons in fetal male germ cells.

  10. purified the three murine Piwi family proteins, MILI, MIWI, and MIWI2, from mouse germ cells and characterized their interacting protein partners

Profil protéine PIWIL4

Profil protéine

PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003

Gene names and symbols associated with PIWIL4

  • piwi like RNA-mediated gene silencing 4 (PIWIL4)
  • piwi-like RNA-mediated gene silencing 4 (Piwil4)
  • 9230101H05Rik Protéine
  • HIWI2 Protéine
  • Miwi2 Protéine

Protein level used designations for PIWIL4

piwi-like 4 , piwi-like protein 4 , mAgo5 , piwi-like homolog 4

GENE ID SPECIES
485123 Canis lupus familiaris
143689 Homo sapiens
330890 Mus musculus
689972 Rattus norvegicus
509545 Bos taurus
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