Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 2 Protéines (PLEKHG2)

May be a transforming oncogene with exchange activity for CDC42. De plus, nous expédions PLEKHG2 Anticorps (10) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PLEKHG2 64857 Q9H7P9
PLEKHG2 101497 Q6KAU7
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails

PLEKHG2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 2 (PLEKHG2) partenaires d'interaction

Human Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 2 (PLEKHG2) interaction partners

  1. This is the first report to show that PLEKHG2 is a novel effector of Galphas (Montrer GNAS Protéines), and is negatively regulated by the Galphas (Montrer GNAS Protéines) subunit through direct interaction.

  2. results provide evidence that FHL1A (Montrer FHL1 Protéines) interacts with PLEKHG2 and regulates cell morphological change through the activity of PLEKHG2.

  3. Role of PLEKHG2 in actin polymerization and clinical and radiological findings in PLEKHG2 deficiency.

  4. Autoantibodies binding to Plekhg2 were found in 19 of 29 patients (66%) with active mycobacterial infections.

  5. The tyrosine phosphorylation of PLEKHG2 plays an important role in EphB2 (Montrer EPHB2 Protéines) signaling, which is closely related to cell growth and the proliferation of tumor.

  6. results provide evidence that stimulation of the Ras/MAPK (Montrer MAPK1 Protéines) pathway by EGFR (Montrer EGFR Protéines) results in FLJ00018 phosphorylation at Thr (Montrer TRH Protéines)-680, which in turn controls changes in cell shape.

  7. PLEKHG2 may serve as a key Gbeta-gamma-stimulated RhoGEF that regulates lymphocyte chemotaxis via Rac and Cdc42 activation and actin polymerization.

  8. These results suggest that FLJ00018 is targeted via its pleckstrin (Montrer PLEK Protéines) homology domain to cellular membranes.

  9. The binding of Rho family specific guanine nucleotide exchange factor(FLJ00018), at least two actin binding regions of FLJ00018, and actin negatively regulates for FLJ00018 function.

  10. Activation of clg (Montrer MMP1 Protéines), a novel dbl (Montrer MCF2 Protéines) family guanine nucleotide exchange factor (Montrer RASGRF1 Protéines) gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias

Profil protéine PLEKHG2

Profil protéine

May be a transforming oncogene with exchange activity for CDC42. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (By similarity).

Gene names and symbols associated with PLEKHG2

  • pleckstrin homology and RhoGEF domain containing G2 (PLEKHG2)
  • pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2)
  • AI194308 Protéine
  • ARHGEF42 Protéine
  • Clg Protéine
  • Cslg Protéine

Protein level used designations for PLEKHG2

PH domain-containing family G member 2 , common-site lymphoma/leukemia guanine nucleotide exchange factor , pleckstrin homology domain-containing family G member 2 , common site lymphoma/leukemia GEF , common site lymphoma/leukemia guanine nucleotide exchange factor , common-site lymphoma/leukemia GEF

GENE ID SPECIES
64857 Homo sapiens
101497 Mus musculus
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