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May be a transforming oncogene with exchange activity for CDC42. De plus, nous expédions PLEKHG2 Anticorps (10) et beaucoup plus de produits pour cette protéine.
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This is the first report to show that PLEKHG2 is a novel effector of Galphas, and is negatively regulated by the Galphas subunit through direct interaction.
results provide evidence that FHL1A interacts with PLEKHG2 and regulates cell morphological change through the activity of PLEKHG2.
Role of PLEKHG2 in actin polymerization and clinical and radiological findings in PLEKHG2 deficiency.
Autoantibodies binding to Plekhg2 were found in 19 of 29 patients (66%) with active mycobacterial infections.
The tyrosine phosphorylation of PLEKHG2 plays an important role in EphB2 signaling, which is closely related to cell growth and the proliferation of tumor.
results provide evidence that stimulation of the Ras/MAPK pathway by EGFR results in FLJ00018 phosphorylation at Thr-680, which in turn controls changes in cell shape.
PLEKHG2 may serve as a key Gbeta-gamma-stimulated RhoGEF that regulates lymphocyte chemotaxis via Rac and Cdc42 activation and actin polymerization.
These results suggest that FLJ00018 is targeted via its pleckstrin homology domain to cellular membranes.
The binding of Rho family specific guanine nucleotide exchange factor(FLJ00018), at least two actin binding regions of FLJ00018, and actin negatively regulates for FLJ00018 function.
Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias
signaling pathway by which G(i)-coupled receptor specifically induces Rac and Cdc42 activation through direct interaction of Gbetagamma with FLJ00018.
May be a transforming oncogene with exchange activity for CDC42. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (By similarity).
PH domain-containing family G member 2
, common-site lymphoma/leukemia guanine nucleotide exchange factor
, pleckstrin homology domain-containing family G member 2
, common site lymphoma/leukemia GEF
, common site lymphoma/leukemia guanine nucleotide exchange factor
, common-site lymphoma/leukemia GEF