Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 6 Protéines (PLEKHG6)

Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. De plus, nous expédions PLEKHG6 Anticorps (51) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PLEKHG6 55200 Q3KR16
PLEKHG6 213522 Q8R0J1
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Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails

PLEKHG6 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 6 (PLEKHG6) partenaires d'interaction

Human Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 6 (PLEKHG6) interaction partners

  1. Intramolecular interactions between MyoGEF domains act as an autoinhibitory mechanism for the regulation of MyoGEF functions.

  2. Taken together, these results suggest that aurora B coordinates with Plk1 to regulate MyoGEF activation and localization, thus contributing to the regulation of cytokinesis.

  3. GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.

  4. ezrin allows the local activation of RhoG at the apical pole of epithelial cells by recruiting upstream and downstream regulators of RhoG and that both PLEKHG6 and ezrin are required for efficient macropinocytosis

  5. Plk1 can regulate MyoGEF activity and localization, contributing to the regulation of cytokinesis

  6. MyoGEF cooperates with nonmuscle myosin IIA to regulate the polarity and invasion activity of breast cancer cells through activation of RhoA and RhoC.

Mouse (Murine) Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 6 (PLEKHG6) interaction partners

  1. GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.

Profil protéine PLEKHG6

Profil protéine

Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Gene names and symbols associated with PLEKHG6

  • pleckstrin homology and RhoGEF domain containing G6 (PLEKHG6)
  • pleckstrin homology domain containing, family G (with RhoGef domain) member 6 (Plekhg6)
  • BC026778 Protéine
  • Gm155 Protéine
  • MyoGEF Protéine

Protein level used designations for PLEKHG6

PH domain-containing family G member 6 , myosin interacting guanine nucleotide exchange factor , myosin-interacting guanine nucleotide exchange factor , pleckstrin homology domain-containing family G member 6

GENE ID SPECIES
55200 Homo sapiens
213522 Mus musculus
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