Poly(rC) Binding Protein 1 (PCBP1) Kits ELISA

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. De plus, nous expédions PCBP1 Anticorps (111) et PCBP1 Protéines (10) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
PCBP1 5093 Q15365
PCBP1 23983 P60335
Anti-Rat PCBP1 PCBP1 500242  
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Top PCBP1 Kits ELISA sur anticorps-enligne.fr

Showing 4 out of 6 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests 11 to 18 Days
Souris < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 to 18 Days
Boeuf (Vache)
  96 Tests 15 to 18 Days
Veuillez renseigner
  10 reactions 4 to 6 Days

Plus Kits ELISA pour PCBP1 partenaires d'interaction

Human Poly(rC) Binding Protein 1 (PCBP1) interaction partners

  1. PCBP2 appears to be an oncogenic splicing factor. A growing body of evidence has shown that PCBP1 regulates alternative splicing, translation, and RNA stability of many cancer-related genes. Taking together, PCBP1 has distinctive tumor suppressive functions, and increasing PCBP1 expression may represent a new approach for cancer treatment.

  2. PCBP1 and miR-3978 are sequestered in normal peritoneal tissue, but disrupted following metastatic progression. PCBP1 expression mimicked miR-3978 expression across gastric cancer patients. Replenishment of miR-3978 in the peritoneal metastasis cell line MKN45 resulted in induction of PCBP1 protein expression, potentially indicating that miR-3978 expression might downregulate a negative regulator targeting PCBP1.

  3. Results thereby indicate that loss of PCBP1 expression firstly attenuates p27 expression at post-transcriptional level, and subsequently promotes carcinogenesis.

  4. the actions of PCBP1 and NCOA4 on ferritin allow erythroid cells to rapidly respond to changes in cellular iron availability, which could provide a strategy to maintain cellular iron storage and utilization at a constant rate despite fluctuation in the total cellular iron supply.

  5. Knockdown of PCBP1 promoted both tumorigenesis and metastatic progression in prostate cancer, suggestive of PCBP1 functioning as a tumor suppressor in normal prostate epithelial cells and potentiates tumor formation by up-regulation of MAPK1 expression.

  6. PCBP1 binds to more severely oxidized RNA to activate apoptosis-related reactions. PCBP1 does not bind to such oligoribonucleotides but instead binds firmly to oligoribonucleotides in which two 8-oxoG residues are located nearby. The structure-function relationship of PCBP1 was established with the use of PCBP1 mutant proteins with defective conserved KH domains. PCBP1 operates when RNA is more severely damaged.

  7. High HNRPE1 expression is associated with pancreatic cancer metastasis.

  8. UBE4A targets PCBP1 for proteasomal degradation and that UBE4A expression can serve as a novel biomarker in thyroid cancer patients.

  9. Study report a novel interaction between mutant HSPB1-P182L and the RNA binding protein PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 in neurodegenerative diseases.

  10. It is reported here that TGF-beta directly regulates alternative splicing of cancer stem cell marker CD44 through a phosphorylated threonine179 of SMAD3-mediated interaction with RNA-binding protein PCBP1.

  11. our findings suggest that PCBP1 is a molecular marker of oxaliplatin resistance in colorectal cancer

  12. Data suggest a 216-nucleotide proximal cis-element in LIF mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin and PCBP1, 2 trans-acting factors that bind to and stabilize LIF mRNA. [LIF = leukemia inhibitory factor; PCBP1 = poly(rC) binding protein 1]

  13. It was concluded that a novel positive feedback loop amplifies hnRNP-E1 during prolonged folate deficiency and thereby maximizes upregulation of folate receptors in order to restore folate homeostasis toward normalcy in placental cells.

  14. TGF-beta signaling through Akt2 induces phosphorylation of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) at serine-43 (p-hnRNP E1), driving epithelial to mesenchymal transition and metastasis.

  15. These results establish the role of hnRNP K and PCPB1 in the translational control of morphine-induced MOR expression in human neuroblastoma (NMB) cells as well as cells stably expressing MOR (NMB1).

  16. The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1, Pcbp1, and RBM39 stabilizes or increases U2 snRNP recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39-mediated splicing regulation.

  17. BC200 RNA interacts with hnRNP E1 and E2 mainly through its unique 3' C-rich domain.

  18. Low expression of PCBP1 is associated with lung cancer metastasis.

  19. We found a C-rich element (CRE) in mu-opioid receptor (MOR) 3'-untranslated region (UTR) to which poly (rC) binding protein 1 (PCBP1) binds, resulting in MOR mRNA stabilization. AUF1 phosphorylation also led to an increased interaction with PCBP1.

  20. miR-7977 in extracellular vesicles may be a critical factor that induces failure of normal hematopoiesis via poly(rC) binding protein 1 suppression in myeloid neoplasms.

Mouse (Murine) Poly(rC) Binding Protein 1 (PCBP1) interaction partners

  1. Iron promoted proinflammatory cytokine expression in T cells via regulating the stability of an RNA-binding protein PCBP1. Intracellular iron protects PCBP1 protein from caspase-mediated proteolysis, and PCBP1 promoted messenger RNA stability of Csf2 and Il2 by recognizing UC-rich elements in the 3' untranslated region.

  2. Study report a novel interaction between mutant HSPB1-P182L and the RNA binding protein PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 in neurodegenerative diseases.

  3. These studies demonstrate the importance of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin.

  4. Pcbp1 modulated the processing of muscle-enriched miR-1, miR-133, and miR-206 by physically interacting with argonaute 2 (AGO2) and other miRNA pathway components.

  5. These data reveal that Pcbp1 and Pcbp2 are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.

  6. PCBP1 may serve as a novel maternal factor.

  7. Our analysis of PCBP1 and PCBP2 expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.

  8. knockdown of PCBP1 led to a reversal effect on the transcriptional inactivation during oocyte growth, which highlights the important role of PCBP1 in maintaining the gobal transcriptional silencing when the growth phase is completed

  9. TGF-beta modulates the expression of Dab2 and ILEI mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1, resulting in its release from a structural, 33-nucleotide BAT element in the 3'UTR of Dab2 and ILEI.

  10. To define the mechanism of STAT3C suppression of transcript. and/or translational activity of NF-kappaB we found that a alphaCP-1 interacted with STAT3C. alphaCP-1 is a K-homol. domain-containing RNA-binding prot with specific for C-rich pyrimidine tracts

PCBP1 profil antigène

Antigen Summary

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Gene names and symbols associated with PCBP1

  • poly(rC) binding protein 1 (PCBP1) anticorps
  • poly(rC) binding protein 1 L homeolog (pcbp1.L) anticorps
  • poly(rC)-binding protein 1 (LOC100388387) anticorps
  • poly(rC) binding protein 1 (Pcbp1) anticorps
  • alphaCP-1 anticorps
  • hnRNP-E1 anticorps
  • hnRNP-X anticorps
  • hnRNP E1 anticorps
  • HNRPE1 anticorps
  • HNRPX anticorps
  • PCBP1 anticorps
  • RGD1561319 anticorps
  • WBP17 anticorps
  • [a]CP-1 anticorps

Protein level used designations for PCBP1

poly(rC) binding protein 1 , poly(rC)-binding protein 1-like , alpha-CP1 , heterogeneous nuclear ribonucleoprotein E1 , heterogenous nuclear ribonucleoprotein E1 , heterogenous nuclear ribonucleoprotein X , nucleic acid-binding protein SUB2.3 , poly(rC)-binding protein 1 , hnRNP-E1 protein , hnRNP E1 , hnRNP-E1

459300 Pan troglodytes
100037147 Xenopus laevis
100388387 Callithrix jacchus
100459720 Pongo abelii
5093 Homo sapiens
509917 Bos taurus
100008848 Oryctolagus cuniculus
23983 Mus musculus
500242 Rattus norvegicus
481417 Canis lupus familiaris
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