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This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. De plus, nous expédions PCBP1 Anticorps (127) et PCBP1 Protéines (10) et beaucoup plus de produits pour cette protéine.
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Knockdown of PCBP1 promoted both tumorigenesis and metastatic progression in prostate cancer, suggestive of PCBP1 functioning as a tumor suppressor in normal prostate epithelial cells and potentiates tumor formation by up-regulation of MAPK1 (Montrer MAPK3 Kits ELISA) expression.
PCBP1 binds to more severely oxidized RNA to activate apoptosis-related reactions. PCBP1 does not bind to such oligoribonucleotides but instead binds firmly to oligoribonucleotides in which two 8-oxoG residues are located nearby. The structure-function relationship of PCBP1 was established with the use of PCBP1 mutant proteins with defective conserved KH domains. PCBP1 operates when RNA is more severely damaged.
High HNRPE1 expression is associated with pancreatic cancer metastasis.
UBE4A targets PCBP1 for proteasomal degradation and that UBE4A expression can serve as a novel biomarker in thyroid cancer patients.
Study report a novel interaction between mutant HSPB1 (Montrer HSPB1 Kits ELISA)-P182L and the RNA binding protein (Montrer PTBP1 Kits ELISA) PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 (Montrer HSPB1 Kits ELISA) in neurodegenerative diseases.
It is reported here that TGF-beta (Montrer TGFB1 Kits ELISA) directly regulates alternative splicing of cancer stem cell marker CD44 (Montrer CD44 Kits ELISA) through a phosphorylated threonine179 of SMAD3 (Montrer SMAD3 Kits ELISA)-mediated interaction with RNA-binding protein (Montrer PTBP1 Kits ELISA) PCBP1.
our findings suggest that PCBP1 is a molecular marker of oxaliplatin resistance in colorectal cancer
Data suggest a 216-nucleotide proximal cis-element in LIF (Montrer LIF Kits ELISA) mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin (Montrer NCL Kits ELISA) and PCBP1, 2 trans-acting factors that bind to and stabilize LIF (Montrer LIF Kits ELISA) mRNA. [LIF (Montrer LIF Kits ELISA) = leukemia inhibitory factor (Montrer LIF Kits ELISA); PCBP1 = poly(rC) binding protein 1]
It was concluded that a novel positive feedback loop amplifies hnRNP-E1 during prolonged folate deficiency and thereby maximizes upregulation of folate receptors in order to restore folate homeostasis toward normalcy in placental cells.
TGF-beta (Montrer TGFB1 Kits ELISA) signaling through Akt2 (Montrer AKT2 Kits ELISA) induces phosphorylation of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) at serine-43 (p-hnRNP E1), driving epithelial to mesenchymal transition and metastasis.
Study report a novel interaction between mutant HSPB1 (Montrer HSPB1 Kits ELISA)-P182L and the RNA binding protein PCBP1, leading to a reduction in its translational repression activity. Identifying PCBP1 mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 (Montrer HSPB1 Kits ELISA) in neurodegenerative diseases.
These studies demonstrate the importance of ferritin (Montrer FTL Kits ELISA) for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin (Montrer FTL Kits ELISA).
Pcbp1 modulated the processing of muscle-enriched miR-1, miR (Montrer MLXIP Kits ELISA)-133, and miR (Montrer MLXIP Kits ELISA)-206 by physically interacting with argonaute 2 (AGO2 (Montrer EIF2C2 Kits ELISA)) and other miRNA pathway components.
These data reveal that Pcbp1 and Pcbp2 are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.
PCBP1 may serve as a novel maternal factor.
Our analysis of PCBP1 and PCBP2 expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.
knockdown of PCBP1 led to a reversal effect on the transcriptional inactivation during oocyte growth, which highlights the important role of PCBP1 in maintaining the gobal transcriptional silencing when the growth phase is completed
TGF-beta (Montrer TGFB1 Kits ELISA) modulates the expression of Dab2 (Montrer DAB2 Kits ELISA) and ILEI (Montrer FAM3C Kits ELISA) mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1, resulting in its release from a structural, 33-nucleotide BAT element in the 3'UTR (Montrer UTS2R Kits ELISA) of Dab2 (Montrer DAB2 Kits ELISA) and ILEI (Montrer FAM3C Kits ELISA).
To define the mechanism of STAT3C suppression of transcript. and/or translational activity of NF-kappaB we found that a alphaCP-1 interacted with STAT3C. alphaCP-1 is a K-homol. domain-containing RNA-binding prot with specific for C-rich pyrimidine tracts
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
poly(rC) binding protein 1
, poly(rC)-binding protein 1-like
, heterogeneous nuclear ribonucleoprotein E1
, heterogenous nuclear ribonucleoprotein E1
, heterogenous nuclear ribonucleoprotein X
, nucleic acid-binding protein SUB2.3
, poly(rC)-binding protein 1
, hnRNP-E1 protein
, hnRNP E1