Poly-U Binding Splicing Factor 60KDa (PUF60) Kits ELISA

PUF60 encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. De plus, nous expédions PUF60 Anticorps (104) et PUF60 Protéines (10) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
PUF60 22827 Q9UHX1
Anti-Souris PUF60 PUF60 67959 Q3UEB3
Anti-Rat PUF60 PUF60 84401  
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Top PUF60 Kits ELISA sur anticorps-enligne.fr

Showing 2 out of 2 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Boeuf (Vache) 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$1,026.67
Détails
Humain < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests 11 to 18 Days
$838.60
Détails

Plus Kits ELISA pour PUF60 partenaires d'interaction

Human Poly-U Binding Splicing Factor 60KDa (PUF60) interaction partners

  1. PUF60-activated exons uncover altered 3' splice-site selection by germline missense mutations in a single RNA recognition motif.

  2. 3 Verheij syndrome patients with de novo pathogenic variants in PUF60 are described. Mutations in gene PUF60 were analyzed.

  3. PUF60 is involved in: 1) up-regulation of core promoter activity through its interaction with transcription factor TCF7L2, 2) promotion of 3.5 kb RNA degradation and 3) suppression of 3.5 kb RNA splicing.

  4. Anti-PUF60 antibodies were nonspecific for myositis, since they could be detected in other rheumatic diseases.

  5. Authors report the identification of 25 DNVs out of which five were classified as pathogenic or likely pathogenic. A two base pair deletion was identified in the PUF60 gene. Result adds to the growing evidence that PUF60 is responsible for the majority of the symptoms reported for carriers of a microdeletion across this region.

  6. The present report describes a de novo missense mutation in PUF60, detected in a boy with multiple congenital anomalies.

  7. PUF60 auto-antibodies are detected in the sera of early-stage colon cancer patients and level decreases after surgery.

  8. These results confirm that PUF60 is a major driver for the developmental, craniofacial, skeletal and cardiac phenotypes associated with the 8q24.3 microdeletion

  9. Heterozygote loss-of-function variants in PUF60 cause a phenotype comprising growth/developmental delay and craniofacial, cardiac, renal, ocular and spinal anomalies.

  10. Mutations in PUF60 gene is associated with idiopathic hypereosinophilic syndrome.

  11. Concomitant over expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer cells.

  12. Overexpression of far upstream element (FUSE) binding protein (FBP)-interacting repressor (FIR) supports growth of hepatocellular carcinoma.

  13. High FBP-interacting repressor expression is associated with hepatocellular carcinoma.

  14. The interaction between SAP155 and FIR/FIRDeltaexon2 not only integrates cell-cycle progression and c-Myc transcription by modifying P27 and P89 expression.

  15. Haploinsufficiency of each of SCRIB or PUF60 contribute uniquely to specific endophenotypes (e.g., coloboma, heart defects), and binary interaction potentially exacerbates other aspects of the clinical pathology of individuals with 8q24.3 deletion.

  16. Circulating FIR variant mRNA in the peripheral blood of cancer patients were significantly overexpressed compared to that in healthy volunteers.

  17. Data indicate that altered FIR and c-myc pre-mRNA splicing, in addition to c-Myc expression by augmented FIR/FIRDeltaexon2-SAP155 complex, potentially contribute to colorectal cancer development.

  18. FIR is monomeric in solution but dimerizes upon DNA binding; DNA-induced dimerization is mediated by FIR's RNA recognition motif.

  19. study identified PUF60 as a factor that promotes splicing of an intron with a weak 3' splice-site; demonstrated that PUF60 can functionally substitute for U2AF(65)in vitro, but splicing is strongly stimulated by the presence of both proteins

  20. Results describe the roles of the FarUpStream Element (FUSE), FUSE Binding Protein (FBP), FBP Interacting Repressor (FIR), and TFIIH in the regulation of c-myc expression.

Zebrafish Poly-U Binding Splicing Factor 60KDa (PUF60) interaction partners

  1. Suppression of scrib and puf60 in zebrafish leads to reduction in body length, small head size, and craniofacial defects.

PUF60 profil antigène

Antigen Summary

This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PUF60

  • poly(U) binding splicing factor 60 (PUF60) anticorps
  • poly-U binding splicing factor a (puf60a) anticorps
  • poly-U binding splicing factor 60 (Puf60) anticorps
  • poly(U) binding splicing factor 60 (Puf60) anticorps
  • 2410104I19Rik anticorps
  • 2810454F19Rik anticorps
  • fc21a05 anticorps
  • FIR anticorps
  • RoBPI anticorps
  • Siahbp1 anticorps
  • wu:fc21a05 anticorps
  • wu:fi43a08 anticorps

Protein level used designations for PUF60

FBP interacting repressor , FUSE-binding protein-interacting repressor , Ro ribonucleoprotein-binding protein 1 , Siah binding protein 1 , poly(U)-binding-splicing factor PUF60 , pyrimidine tract binding splicing factor , 60 kDa poly(U)-binding-splicing factor , fuse-binding protein-interacting repressor , RNA-binding protein Siah-BP , poly-U binding splicing factor 60K , siah binding protein 1; FBP interacting repressor; pyrimidine tract binding splicing factor; Ro ribonucleoprotein-binding protein 1 , siah-binding protein 1 , LOW QUALITY PROTEIN: poly(U)-binding-splicing factor PUF60 , poly(U) binding splicing factor 60KDa

GENE ID SPECIES
22827 Homo sapiens
562370 Danio rerio
67959 Mus musculus
84401 Rattus norvegicus
607245 Canis lupus familiaris
512824 Bos taurus
100174042 Pongo abelii
100734967 Cavia porcellus
426402 Gallus gallus
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