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POLDIP3 encodes a protein that interacts with the DNA polymerase delta p50 subunit. De plus, nous expédions POLDIP3 Anticorps (76) et beaucoup plus de produits pour cette protéine.
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Altered expression of PDIP46 or its mutation may affect Pol delta functions in vivo, and thereby be a nexus for altered genomic stability.
hnRNP-U inhibits TDP-43-mediated alterations in splicing of POLDIP3 mRNA.
PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export.
these findings establish critical and essential roles for SKAR in the regulation of mRNA translation of IFN-sensitive genes and induction of IFN-alpha biological responses.
Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with amyotrophic lateral sclerosis (ALS) .
SKAR is a specific target of S6K1 and regulates cell growth.
This study showed that PDIP46 aka SKAR, a protein possessing one RNA recognition motif (RRM) and being a protein partner of both the p50 subunit of DNA polymerase delta and p70 ribosomal protein S6 kinase 1 (S6K1).
SKAR-mediated recruitment of activated S6K1 to newly processed mRNPs serves as a conduit between mTOR checkpoint signaling and the pioneer round of translation when cells exist in conditions supportive of protein synthesis.
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.
DNA polymerase delta interacting protein 3
, polymerase delta-interacting protein 3
, 46 kDa DNA polymerase delta interaction protein
, RNA-binding protein P46
, S6K1 Aly/REF-like target
, polymerase delta interacting protein 46