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Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. De plus, nous expédions Potassium Channel, Subfamily K, Member 4 Protéines (5) et beaucoup plus de produits pour cette protéine.
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Cow (Bovine) Polyclonal KCNK4 Primary Antibody pour WB - ABIN2776270
Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: The LIFEdb database in 2006. dans Nucleic acids research 2005
Show all 2 Pubmed References
Functional alanine-mutagenesis screens of TASK-1 and TRAAK were used to build an in silico model of the TASK-1 cap.
KCNK4 promoter methylation is associated with Breast Cancer.
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.
findings uncover a unique aspect of potassium channel modulation, indicate a means for how the channel C-terminal cytoplasmic domain affects the C-type gate, and suggest how lipids and bilayer inner leaflet deformations gate the channel.
TRAAK is responsive to mechanical forces similar to the ion channel Piezo1; mechanical activation of TRAAK can electrically counter Piezo1 activation.
structure reveals a domain-swapped chain connectivity enabled by the helical cap that exchanges two opposing outer helices 180 degrees around the channel
crystal structure of TRAAK at 3.8 angstroms resolution; channel comprises 2 protomers that create 2-fold symmetric K(+) channel; extracellular surface has a helical cap; 2 diagonally opposed gate-forming inner helices form membrane-interacting structures
role for TREK-1 in contributing to uterine quiescence during gestation
Human TASK-3 was cloned and expressed; protein sequence and activity compared to similar two pore domain potassium channels, including KCNK4 (TRAAK).
Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins
The beneficial effects of TRAAK deletion designate this channel as a promising pharmacological target for the treatment against stroke.
Polycystins protect renal epithelial cells against apoptosis in response to mechanical stress, and this function is mediated through the opening of stretch-activated K(2P) channels.
The TRAAK appears to be strongly involved in regulating airway mechanosensing since it was found to be expressed on the terminals of all subpopulations of potential vagal mechanosensors.
TREK-1, TREK-2, and TRAAK are lysophosphatidic acid-operated K+ channels
primary observation is that the mechanosensitive K2P channels TREK-1 and TRAAK desensitize; desensitization and its regulation by chemical messengers is predicted to condition the physiological role of K2P channels
Together TREK-1 and TRAAK channels are important regulators of nociceptor activation by cold, particularly in the nociceptor population that is not activated by menthol.
Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids.
K2P4.1 potassium channel
, TWIK-related arachidonic acid-stimulated potassium channel protein
, potassium channel subfamily K member 4
, two pore K(+) channel KT4.1
, two pore K+ channel KT4.1
, two pore potassium channel KT4.1
, protein expressed in male leptotene and zygotene spermatocytes 622
, potassium inwardly-rectifying channel subfamily K member 4
, potassium inwardly-rectifying channel, subfamily K, member 4