Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 Protéines (KCNJ6)

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. De plus, nous expédions Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 Anticorps (73) et beaucoup plus de produits pour cette protéine.

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KCNJ6 3763 P48051
KCNJ6 16522 P48542
KCNJ6 25743 P48550
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Top Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 Protéines sur anticorps-enligne.fr

Showing 7 out of 7 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
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Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
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Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
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Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,493.38
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Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$230.67
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$888.80
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Escherichia coli (E. coli) Humain Inconjugué   5 applications Connectez-vous pour afficher 1 to 2 Days
$318.85
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KCNJ6 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

Plus protéines pour Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6) partenaires d'interaction

Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6) interaction partners

  1. Gi/o-coupled muscarinic receptors co-localize with GIRK channel for efficient channel activation

  2. The KCNJ6 -1250A and COMT Val alleles are predisposing preterm newborns to diminished opioid-induced pain relief.

  3. The major findings of the current study are 1) an additive genotypic effect of the KCNJ6 SNP on the ERO theta power phenotype during reward processing, increasing significantly across genotypes.

  4. Three of the four KCNJ6 SNPs studied here were found to be significantly associated with the same theta event related oscillations in adults.

  5. The findings of this study suggest that variations in KCNJ6 genes are associated with both mild and severe persistent breast pain after breast cancer surgery.

  6. KCNJ6 (GIRK2) gene polymorphism rs2835859 could serve as a marker that predicts sensitivity to analgesics and pain and susceptibility to nicotine dependence.

  7. In this transgenic mouse model, GIRK2 plays a major role in the genesis of infantile spasms.

  8. Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6.

  9. For KCNJ6, three SNPs (i.e., rs2835914, rs8129919, rs2836050) were associated with the occurrence of preoperative breast pain.

  10. Eight KCNNJ6 single nucleotide polymorphisms(SNPs) are significantly associated with pain-related phenotypes.

  11. Ethanol associates directly with the GIRK channel, leading to enhanced interaction with a membrane phospholipid phosphatidylinositol 4,5-bisphosphate and activation of the channel.

  12. 3.5 A resolution crystal structure of the mammalian GIRK2 channel in complex with betagamma G-protein subunits, the central signalling complex that links G-protein-coupled receptor stimulation to K(+) channel activity

  13. KCNJ6 (or its product GIRK2) accounts for some of the variations in frontal theta; band oscillations.

  14. Conformational information encoded by ligand binding to delta-opioid receptors (DORs) is transmitted to Kir3.1/Kir3.2 channels.

  15. GIRK2 is expressed in nearly every human pigmented neuron or mouse tyrosine hydroxylase-immunoreactive neuron in both the substantia nigra and ventral tegmental areas.

  16. GIRK overexpression in Ts65Dn mice has functional consequences affecting balance between GABA(A) and GABA(B) inhibition of CA1 pyramidal neurons in a pathway specific manner, that may contribute to cognitive deficits in Ts65 mouse model of Down syndrome.

  17. KCNJ6 is associated with alcohol dependence and may moderate the effect of early psychosocial stress on risky alcohol drinking in adolescents

  18. This study is the first to identify the expression of GIRK2-4 subunits in human esophageal smooth muscle cells.

  19. The KCNJ6 promoter is activated by Trichostatin A (TSA) treatment and by serum depletion according to promoter reporter assays in HEK 293 cells.

  20. significant interaction between the TT genotype of rs2070995 (located in KCNJ6) and the GG genotype of rs2253206 (located in CREB1) on rumination were found

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6) interaction partners

  1. These results reveal selective small molecule binding and uncover a mechanism by which rotation of the cytoplasmic domain can modulate GIRK*phosphatidylinositide interactions.

  2. The results of this study indicated that Kcnj6 triploid mice show an increase in GIRK2 protein levels compared to WT mice in the cortex and thalamus.

  3. GIRK2 isoform balance within a neuron can impact the processing of afferent inhibitory input and associated behavior.

  4. Locomotor activity of the mice was not changed compared to that of GIRK2(floxed) mice, when tested in the open field

  5. Results indicate that the properties and inhibitory activity of dorsal raphe neurons are highly regulated by G protein-coupled inwardly rectifying K+ (GIRK) 2 subunit-containing channels, introducing GIRK channels as potential candidates for studying the pathophysiology and treatment of affective disorders.

  6. Increased Kcnj6 gene dose is necessary for synaptic and cognitive dysfunction in the animal model of Down Syndrome.

  7. The GABABR-coupled GIRK2 channel is necessary for the GABABR agonist-induced infantile spasms phenotype in the Ts mouse and may represent a novel therapeutic target for the treatment of infantile spasms in Down syndrome.

  8. It was concluded that GIRK2, through its dual responsiveness to G protein beta-gamma and Na+, mediates a form of neuronal inhibition that is amplifiable in the setting of excess electrical activity.

  9. cholesterol did not affect the unitary conductance of GIRK2, it significantly enhanced the frequency of channel openings.

  10. Results indicate that GIRK channels formed by GIRK2 subunits determine depression-related behaviors as well as basal and 5-HT1A receptor-mediated dorsal raphe neuronal activity

  11. This study showed that spontaneous GIRK2 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.

  12. This study demonstrated that the residue Ser-196 in Kir3.2 is involved in conferring PKC-mediated inhibition to the channel.

  13. In the ventral tegmental area, GABA neurons express both GIRK2 (and GIRK1) subunits.

  14. Gbeta-gamma and PIP2 must be present simultaneously to activate GIRK2.

  15. Ligand-operated activation of Kir3.2 appears to cause dilation of the pore at the cytoplasmic domain, and is regulated conformationally.

  16. A subcellular GIRK2c/GIRK3 pathway is identified that regulates excitability of ventral tegmental area dopamine neurons.

  17. The results of this study show that Girk2 gene mutation alters electric activity of LC neurons in vivo.

  18. Altogether, these findings shed new light on the developmental regulation of GIRK channels in the cerebellum

  19. In the dorsal horn of the developing rat, K(ir)3.1 and K(ir)3.2 were expressed at mature levels from birth.

  20. GIRK2 mediates the mGluR-sensitive current in unipolar brush cells

Profil protéine Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6)

Profil protéine

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.

Gene names and symbols associated with KCNJ6

  • potassium voltage-gated channel subfamily J member 6 (KCNJ6)
  • potassium channel, inwardly rectifying subfamily J, member 5 (kcnj5)
  • potassium inwardly-rectifying channel, subfamily J, member 6 (KCNJ6)
  • potassium inwardly-rectifying channel, subfamily J, member 6 (Kcnj6)
  • potassium voltage-gated channel subfamily J member 6 (Kcnj6)
  • BIR1 Protéine
  • GIRK-2 Protéine
  • GIRK2 Protéine
  • hiGIRK2 Protéine
  • KATP-2 Protéine
  • KATP2 Protéine
  • kcnj6 Protéine
  • KCNJ7 Protéine
  • Kir3.2 Protéine
  • weaver Protéine
  • wv Protéine

Protein level used designations for KCNJ6

potassium inwardly-rectifying channel, subfamily J, member 6 , G-protein-coupled inward rectifier potassium channel , G protein-activated inward rectifier potassium channel 2 , inward rectifier K(+) channel Kir3.2 , inward rectifier potassium channel KIR3.2 , GIRK-2 , potassium channel, inwardly rectifying subfamily J member 6 , potassium inwardly-rectifying channel J6 , BIR1 , GIRK2 , KATP-2 , Inward rectifier K(+) channel Kir3.2 , Potassium channel, inwardly rectifying subfamily J member 6 , potassium channel-like protein

GENE ID SPECIES
427983 Gallus gallus
520743 Bos taurus
549655 Xenopus (Silurana) tropicalis
100625084 Sus scrofa
3763 Homo sapiens
16522 Mus musculus
25743 Rattus norvegicus
101823647 Mesocricetus auratus
100174134 Pongo abelii
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