anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Anticorps

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. De plus, nous expédions Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
KCNQ2 3785 O43526
KCNQ2 16536 Q9Z351
KCNQ2 170848 O88943
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Top anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 109 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-KCNQ2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Jurkat cell lysate Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5µg/ml using anti-KCNQ2 antibody (ARP35458_P050) 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB WB Suggested Anti-KCNQ2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  NCI-H226 cell lysate There is BioGPS gene expression data showing that KCNQ2 is expressed in NCIH226 Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5µg/ml using anti-KCNQ2 antibody (ARP35457_P050) 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-KCNQ2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  HepG2 cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-Kcnq2 Antibody   Titration: 1.0 ug/ml   Positive Control: Mouse Brain 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB Anti-KCNQ2 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN958389 concentration 5 ug/ml. Anti-KCNQ2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Ot ... 50 μg Connectez-vous pour afficher 11 to 14 Days
$727.83
Détails
Humain Souris Inconjugué ICC, IHC, IHC (p), IP, WB Anti-KCNQ2 antibody IHC staining of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1102723 concentration 20 ug/ml. IHC analysis of KCNQ2 in frozen sections of mouse brain using KCNQ2 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested. 100 μg Connectez-vous pour afficher 11 to 14 Days
$727.83
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB 100 μg Connectez-vous pour afficher 11 to 14 Days
$493.17
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB Human Heart (formalin-fixed, paraffin-embedded) stained with KCNQ2 antibody ABIN214789 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-KCNQ2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other form ... 50 μg Connectez-vous pour afficher 11 to 14 Days
$727.83
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB Anti-KCNQ2 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN958996 concentration 5 ug/ml. Anti-KCNQ2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product ... 50 μg Connectez-vous pour afficher 11 to 14 Days
$727.83
Détails
Hamster Souris HRP AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 µl for 5 minutes at RT. Western Blot analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Clone S26A-23 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed. 100 μg Connectez-vous pour afficher 3 to 4 Days
$499.20
Détails

anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Anticorps mieux référencés

  1. Mammalian Monoclonal KCNQ2 Primary Antibody pour ISt, IHC - ABIN1304776 : Miceli, Soldovieri, Ambrosino, De Maria, Migliore, Migliore, Taglialatela: Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 (PubMed)
    Show all 12 Pubmed References

  2. Cow (Bovine) Polyclonal KCNQ2 Primary Antibody pour IHC, WB - ABIN2776304 : Tang, Li, Xia, Jiang, Pan, Shen, Long, Zhao, Cai: A novel mutation in KCNQ2 gene causes benign familial neonatal convulsions in a Chinese family. dans Journal of the neurological sciences 2004 (PubMed)
    Show all 3 Pubmed References

Plus d’anticorps contre Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 partenaires d’interaction

Human Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. An optimum cholesterol level in the plasma membrane is required for the proper functioning of Kv7.2/Kv7.3 (Montrer KCNQ3 Anticorps) channels.

  2. Study describes the interactions of hposphatidylinositol-4,5-bisphosphate with both the open and closed states of a KCNQ2 channel. Through these methods, results show that a lipid can migrate between different binding sites in a protein and this migration modulates protein functions.

  3. A distinctive ictal amplitude-integrated EEG pattern occurs in newborns with neonatal epilepsy associated with KCNQ2 mutations.

  4. patients with the KCNQ2 E515D mutation are susceptible to seizures.

  5. he present study involves identification of newer anti-epileptic agents by means of a computer-aided drug design adaptive protocol involving both structure-based virtual screening of Asinex library using homology model of KCNQ2 and 3D-QSAR based virtual screening with docking analysis, followed by dG bind and ligand efficiency calculations with ADMET studies, of which 20 hits qualified all the criterions.

  6. This study provided evidence to suggests that the p.R213Q mutation has a dominant-negative effect on the current amplitude of homomeric wild-type and mutant KCNQ2 constructs, which correlates with clinical seizure frequencies and neurodevelopmental outcomes.

  7. Mutations in STXBP1 (Montrer STXBP1 Anticorps) encoding the syntaxin binding protein 1 (Montrer STXBP1 Anticorps) can produce a phenotype similar to that of KCNQ2 mutations

  8. whole exome sequencing in families with ID and history of autosomal dominant inheritance pattern with or without seizures, may further broaden the phenotypic spectrum of KCNQ2 associated epileptic encephalopathy or encephalopathy

  9. The direct effect of heat on KCNQ2 channels may be involved in excitability regulation of neurons, and the P-loop region is critical for temperature-dependent modulation of the expression and trafficking of KCNQ2 channels.

  10. Epileptic encephalopathy with burst suppression without brain malformations is associated with pathogenic variation in KCNQ2.

Mouse (Murine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. The data of this study showed that, in Kcnq2 mutant slices, burst activity was modulated by GABAA (Montrer GABRg1 Anticorps) receptor blockade.

  2. Kcnq2 ablation leads to increased neuronal excitability of neocortex layer 2/3 pyramidal neurons.

  3. USP36 (Montrer USP36 Anticorps) actions extend beyond TrkA (Montrer NTRK1 Anticorps) because the presence of USP36 (Montrer USP36 Anticorps) interferes with Nedd4-2 (Montrer NEDD4L Anticorps)-dependent Kv7.2/3 channel regulation.

  4. Mechanosensitivity of Skin Down-hair mechanoeceptors is increased in Kcnq3 (Montrer KCNQ3 Anticorps)-/- and in Kcnq2+/-/Kcnq3 (Montrer KCNQ3 Anticorps)-/- Mutant Mice.

  5. Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity.

  6. Reduced M-current in the superior cervical ganglion neurons of Kcnq2 truncation mutation heterozygotic mice.

  7. Data show that a reduction in Kv7.2/3 channel activity is essential for tinnitus induction and for the tinnitus-specific hyperactivity.

  8. Retigabine is more effective on KCNQ3 (Montrer KCNQ3 Anticorps) than KCNQ2, whereas ZnPy is more effective on KCNQ2 with no detectable effect on KCNQ3 (Montrer KCNQ3 Anticorps).

  9. Results show that in the same protein complex in which PKA augments L currents, AKAP79 (Montrer AKAP5 Anticorps)/150 directs calcineurin to activate NFAT (Montrer NFATC1 Anticorps) and initiate a longer-term feedback loop that upregulates M-channel expression, countering increased neuronal excitability.

  10. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 (Montrer KCNQ3 Anticorps) > KCNQ4 (Montrer KCNQ4 Anticorps) > KCNQ5 (Montrer KCNQ5 Anticorps) > KCNQ1 (Montrer KCNQ1 Anticorps) > KCNQ2.

Horse (Equine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. The KCNQ2 and KCNQ3 (Montrer KCNQ3 Anticorps) genes are located on the terminal region of chromosomes 22 and 9, respectively. The KCNQ2 gene tree exhibited close clustering between horses and humans, relative to horses and mice.

Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) profil antigène

Profil protéine

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.

Gene names and symbols associated with KCNQ2

  • potassium voltage-gated channel subfamily Q member 2 (KCNQ2) anticorps
  • potassium voltage-gated channel, subfamily Q, member 2 (Kcnq2) anticorps
  • potassium voltage-gated channel subfamily Q member 2 (Kcnq2) anticorps
  • potassium voltage-gated channel subfamily KQT member 2 (LOC100537363) anticorps
  • potassium voltage-gated channel, KQT-like subfamily, member 2a (kcnq2a) anticorps
  • BFNC anticorps
  • BFNS1 anticorps
  • EBN anticorps
  • EBN1 anticorps
  • EIEE7 anticorps
  • ENB1 anticorps
  • HNSPC anticorps
  • KCNA11 anticorps
  • KQT2 anticorps
  • KV7.2 anticorps
  • KVEBN1 anticorps
  • mKQT2.3 anticorps
  • mKQT2.4 anticorps
  • Nmf134 anticorps
  • zgc:171872 anticorps

Protein level used designations for KCNQ2

KQT-like 2 , neuroblastoma-specific potassium channel protein , neuroblastoma-specific potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel subfamily KQT member 2 , voltage-gated potassium channel subunit Kv7.2 , potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel, subfamily Q, member 2 , potassium voltage-gated channel KQT-like subfamily member 2.3 , potassium voltage-gated channel KQT-like subfamily member 2.4 , potassium voltage-gated channel, KQT-like subfamily, member 2 , LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 2 , uncharacterized protein LOC100141342

GENE ID SPECIES
3785 Homo sapiens
16536 Mus musculus
170848 Rattus norvegicus
100537363 Danio rerio
428151 Gallus gallus
100146986 Equus caballus
505963 Bos taurus
612515 Canis lupus familiaris
100732168 Cavia porcellus
101118630 Ovis aries musimon
100141342 Danio rerio
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