Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 5 Protéines (KCNQ5)

KCNQ5 is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. De plus, nous expédions KCNQ5 Anticorps (72) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat KCNQ5 KCNQ5 259273  
KCNQ5 56479 Q9NR82
KCNQ5 226922 Q9JK45
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 60 to 65 Days
$10,888.92
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 60 to 65 Days
$7,639.51
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails

KCNQ5 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

KCNQ5 Protéines mieux référencés

  1. Human KCNQ5 Protein expressed in Wheat germ - ABIN1308482 : Caminos, Vaquero, Martinez-Galan: Relationship between rat retinal degeneration and potassium channel KCNQ5 expression. dans Experimental eye research 2015 (PubMed)

Plus protéines pour Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 5 (KCNQ5) partenaires d'interaction

Human Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 5 (KCNQ5) interaction partners

  1. identified P2RX2 (Montrer P2RX2 Protéines), KCNQ5, ERBB3 (Montrer ERBB3 Protéines) and SOCS3 (Montrer SOCS3 Protéines) to be associated with the progression of age-related hearing impairment

  2. Our data support the involvement of KCNQ5 gene polymorphisms in the genetic susceptibility to high myopia and further exploration of KCNQ5 as a risk factor for high myopia.

  3. These findings provide the first evidence linking PKC (Montrer PRRT2 Protéines) activation to suppression of Kv7 currents, membrane depolarization, and Ca(2 (Montrer CA2 Protéines)+) influx via L (Montrer COX6A1 Protéines)-type voltage-sensitive Ca(2 (Montrer CA2 Protéines)+) channels as a mechanism for histamine-induced bronchoconstriction.

  4. both loss-of-function and gain-of-function KCNQ5 mutations, associated with increased excitability and decreased repolarization reserve, lead to pathophysiology.

  5. Tannic acid activates Kv7.4 and Kv7.3/7.5 K(+) channels resulting in vasodilation.

  6. rs9351963 in KCNQ5 is a possible predictive factor of incidence of diarrhea in cancer patients treated with irinotecan chemotherapy.

  7. suggestive loci for periodontitis: KCNQ5 on chromosome 6q13 in a Japanese population. study should contribute to further understanding of genetic factors for enhanced susceptibility to periodontitis.

  8. Kv7.1 (Montrer KCNQ1 Protéines)/Kv7.5 form heterotetrameric channels increasing the diversity of structures which fine-tune blood vessel reactivity. The lipid raft localization of Kv7.1 (Montrer KCNQ1 Protéines)/Kv7.5 heteromers provides efficient spatial and temporal regulation of smooth muscle function.

  9. Differential protein kinase C-dependent modulation of Kv7.4 (Montrer KCNQ4 Protéines) and Kv7.5 subunits of vascular Kv7 channels.

  10. characterized the cell-type specific spatial organization of the kcnq5 gene locus mediated by CTCF (Montrer CTCF Protéines) in detail using chromosome conformation capture (3C) and 3C-derived techniques

Mouse (Murine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 5 (KCNQ5) interaction partners

  1. KCNQ5 controls excitability and function of hippocampal networks through modulation of synaptic inhibition.

  2. analysis of the vestibular role of KCNQ4 (Montrer KCNQ4 Protéines) and KCNQ5 K+ channels revealed by mouse models

  3. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 > KCNQ4 (Montrer KCNQ4 Protéines) > KCNQ5 > KCNQ1 (Montrer KCNQ1 Protéines) > KCNQ2 (Montrer KCNQ2 Protéines).

  4. Kcnq5(dn/dn (Montrer TMC1 Protéines)) mice are viable and have normal brain morphology. However, in the CA3 (Montrer CA3 Protéines) area of hippocampus, a region that highly expresses KCNQ5 channels, the medium and slow afterhyperpolarization currents are significantly reduced.

  5. Data show that murine KCNQ5 channels are tightly regulated by changes in extracellular Zn2+, pH, and tonicity, thus adding to the complex regulation of these channels.

  6. Murine blood vessels exhibit a distinctive expression profile of KCNQ1 (Montrer KCNQ1 Protéines), KCNQ4 (Montrer KCNQ4 Protéines), and KCNQ5, with 'neuronal' KCNQ4 (Montrer KCNQ4 Protéines) dominating

  7. These data represent an exhaustive characterisation of a truncated KCNQ5 splice variant that may contribute to the native XE991-sensitive channel in murine vasculature.

  8. Results provide support for KCNQ4 (Montrer KCNQ4 Protéines)- or KCNQ5-encoded channels having an important functional impact in the vasculature.

  9. K(v)7.4 (Montrer KCNQ4 Protéines) and K(v)7.5 are expressed in different regions of the murine gastrointestinal tract and blockers of K(v)7 channels augment inherent contractile activity.

Profil protéine KCNQ5

Profil protéine

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KCNQ5

  • potassium voltage-gated channel subfamily Q member 5 (KCNQ5)
  • potassium voltage-gated channel, KQT-like subfamily, member 5a (kcnq5a)
  • potassium voltage-gated channel subfamily Q member 5 (Kcnq5)
  • potassium voltage-gated channel, KQT-like subfamily, member 5 (KCNQ5)
  • potassium voltage-gated channel, subfamily Q, member 5 (Kcnq5)
  • 7730402H11 Protéine
  • 9230107O05Rik Protéine
  • AA589396 Protéine
  • D1Mgi1 Protéine
  • KCNQ5 Protéine
  • Kcnq5l Protéine
  • Kv7.5 Protéine
  • si:dkey-29l6.1 Protéine

Protein level used designations for KCNQ5

potassium voltage-gated channel, KQT-like subfamily, member 5 , potassium voltage-gated channel subfamily KQT member 5-like , potassium voltage-gated channel subfamily KQT member 5 , potassium voltage-gated channel, subfamily Q, member 5 , KQT-like 5 , potassium channel protein , potassium channel subunit alpha KvLQT5 , voltage-gated potassium channel subunit Kv7.5 , voltage-gated potassium channel type Kv7.5

GENE ID SPECIES
462817 Pan troglodytes
556841 Danio rerio
613605 Bos taurus
100411503 Callithrix jacchus
259273 Rattus norvegicus
56479 Homo sapiens
474965 Canis lupus familiaris
100328657 Oryctolagus cuniculus
226922 Mus musculus
100154391 Sus scrofa
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