anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5) Anticorps

Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. De plus, nous expédions Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 Protéines (4) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
KCNA5 3741 P22460
KCNA5 16493 Q61762
KCNA5 25470 P19024
Comment commander chez anticorps-enligne
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 Anticorps sur anticorps-enligne.fr

Showing 10 out of 104 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB WB Suggested Anti-KCNA5 Antibody Titration: 1.0 ug/ml Positive Control: HepG2 Whole Cell 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Boeuf (Vache) Lapin Inconjugué WB Western blot analysis of Kv1.5 expression in MCF7 (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué WB 0.1 mg Connectez-vous pour afficher 6 to 8 Days
$467.50
Détails
Boeuf (Vache) Lapin Inconjugué IP, WB 0.1 mL Connectez-vous pour afficher 7 to 9 Days
$418.10
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL Connectez-vous pour afficher Disponible
$363.46
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, WB Western blot analysis of extracts from 293 cells, using KCNA5 antibody.The lane on the left is treated with the antigen-specific peptide. ABIN6275378 staining  293 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué WB KCNA5 Antibody (C-term)  western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the KCNA5 antibody detected the KCNA5 protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Anti-KCNA5 / Kv1.5 antibody IHC staining of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1102664 concentration 10 ug/ml. Anti-KCNA5 / Kv1.5 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 100 μL Connectez-vous pour afficher 11 to 14 Days
$639.83
Détails
Humain Lapin Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 2 to 3 Days
$302.50
Détails

anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 Anticorps mieux référencés

  1. Mammalian Monoclonal KCNA5 Primary Antibody pour ISt, IHC - ABIN1304754 : Pott, Ren, Tran, Yang, Henderson, Jordan, Roos, Garfinkel, Philipson, Goldhaber: Mechanism of shortened action potential duration in Na+-Ca2+ exchanger knockout mice. dans American journal of physiology. Cell physiology 2007 (PubMed)
    Show all 14 Pubmed References

  2. Cow (Bovine) Polyclonal KCNA5 Primary Antibody pour IP, WB - ABIN449232 : Zhou, Ma, Huang: Specific antibodies to the external vestibule of voltage-gated potassium channels block current. dans The Journal of general physiology 1998 (PubMed)

  3. Dog (Canine) Polyclonal KCNA5 Primary Antibody pour IF (p), IHC (p) - ABIN735158 : Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. dans Basic research in cardiology 2014 (PubMed)

Plus d’anticorps contre Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 partenaires d’interaction

Human Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5) interaction partners

  1. Verapamil acts as an open-channel blocker of hKv1.5 channel, presumably due to direct binding to specific amino acids within pore region of hKv1.5 channel, such as Thr479, Thr480, Val505, Ile508, Val512 and Val516.

  2. The N terminus and transmembrane segment S1 of Kv1.5 can co-assemble with the rest of the channel independently of the S1-S2 linkage.

  3. Molecular dynamics simulations are employed to determine the inhibitory mechanisms of three drugs, 5-(4-phenoxybutoxy)psoralen (PAP-1), vernakalant, and flecainide, on the voltage-gated K(+) channel Kv1.5, a target for the treatment of cardiac arrhythmia.

  4. This study adds insights to the functional impact of KCNA5 mutations in modulating atrial contractile functions.

  5. In addition, as IKur is an atrial-specific channel and a number of IKur-selective blockers have been developed as anti-AF agents, this study also helps to understand some contradictory results on both pro- and anti-arrhythmic effects of blocking IKur.

  6. our finding indicated that KCNA5 protein may interact with Cav-1, thereby contributing to the proliferation and early transformation of mammary cells.

  7. Putative binding sites for arachidonic acid on the human cardiac Kv 1.5 channel

  8. Studies demonstrate that DNA hypermethylation contributes to epigenetic repression of the KCNA5 locus and that the resulting suppression of the Kv1.5 ion channel supports cancer cell proliferation.

  9. Kv1.5 expression is increased in osteosarcoma cells and tissues and shRNA mediated silencing of Kv1.5 results in cell proliferation inhibition, cell cycle arrest, and induces cell apoptosis.

  10. Direct interaction with specific amino acids underlies the blocking action of propofol on voltage-gated hKv1.5 channel.

  11. demonstrate that PK treatment cleaved mature membrane-bound (75kDa) Kv1.5 channels at a single locus in the S1-S2 linker, producing 42-kDa N-terminal fragments and 33-kDa C-terminal fragments

  12. These results indicate that CHIP decreases the Kv1.5 protein level and functional channel by facilitating its degradation in concert with chaperone Hsc70

  13. The expression of Kv1.5 channel protein changes with atrial fibrillation but not with age, rheumatic heart diseases, and sex in atrial fibrillation.

  14. One KCNA5 variant, H463R, was a novel mutation; the histidine at codon 463 is located in the S5-pore loop, in the vicinity of the pore of KV1.5 subunit. The other variant, T527M, showed a gain-of-function effect with an enhanced steady-state activation.

  15. The KCNA5 promoter is marked in cancer cells with PcG-dependent chromatin repressive modifications that increase in hypoxia.

  16. Mutations in KCNA5 gene is not associated with pulmonary arterial hypertension.

  17. Protein kinase C inhibition results in a Kv 1.5 and Kv beta 1.3 pharmacology closer to Kv 1.5 channels

  18. Data do not indicate an important role of potassium voltage-gated channel shaker-related subfamily member 5 (KCNA5) as a sclerosis (SSc)-susceptibility factor or as a pulmonary arterial hypertension (PAH)-development genetic marker for SSc patients.

  19. isoform betaII plays a central role in the PKC-dependent regulation of Kv1.5/Kvbeta1.2 channels.

  20. These results indicate that low temperature exposure stabilizes the protein in the cellular organelles or on the plasma membrane, and modulates its maturation and trafficking, thus enhancing the currents of hKv1.5 and its trafficking defect mutants.

Mouse (Murine) Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5) interaction partners

  1. KV1.5 channels predominantly associate with KVbeta1 and KVbeta2 proteins and that KVbeta2 performs a chaperone function for KV1.5 channels in arterial myocytes, thereby facilitating Kv1alpha trafficking and membrane localization.

  2. The findings uncover detailed molecular mechanisms underpinning a channelopathy-linked form of atrial fibrillation and emphasize the inevitability of considering extracardiac mechanisms in genetic arrhythmia syndromes.

  3. Silencing of Kv1.5 improved endothelium-dependent vasodilatation in thoracic aorta from type 2 diabetes mice.

  4. Intracellular urate taken up by UATs enhanced Kv1.5 protein expression and function in HL-1 atrial myocytes.

  5. JAK3 contributes to the regulation of membrane Kv1.5 protein abundance and activity, an effect sensitive to ouabain and thus possibly involving Na(+)/K(+) ATPase activity.

  6. KV1.5, a DPO-1-sensitive KDR channel, plays a major role in determining microvascular tone and the response to vasoconstrictors and vasodilators.

  7. Kv1.5 channels in vascular smooth muscle play a critical role in coupling myocardial blood flow to cardiac metabolism.

  8. the Kv1.5 subunit has a role in electrical remodeling of preoptic GABAergic neurons

  9. MYO5A and MYO5B control functionally distinct steps in the surface trafficking of Kv1.5.

  10. e-LXA4 promoted a modest upregulation of Kv1.5 mRNA that was suppressed by LPS or IL-4/IL-13.

  11. The combined down-regulation of Kv4.2, Kv1.5 and KChIP2 prior to the onset of HF may play an important role in the premature sudden death in this DCM model.

  12. cortactin was required for N-cadherin-mediated enhancement of Kv1.5 channel activity

  13. Data confirm KCNA5 in left/right atria & indicate functional interaction of KCNA5 (ultra rapid) & KCNH2 (rapid). Action potentials are longer in right atrial myocytes than in left; this is due partly to smaller amplitude of KCNA5 in right atrium.

  14. KChIP2 contributes to the formation of functional mouse ventricular Kv1.5 channels

  15. hyperthyroidism resulted in more significant action potential shortening and greater delayed rectifier K(+) current increases in the right vs. the left atrium, which can contribute to the propensity for atrial arrhythmia in hyperthyroid heart

  16. Kv1.5 co-associates with Kv1.3, generating functional heterotetramers in macrophages

  17. Kv1.3-based treatments to alter physiological responses, such as proliferation and activation, are impaired by Kv1.5 expression

  18. Our results show that Kcna5 promoter activity in vascular smooth muscle is critically dependent on Sp1 regulation via CACCC box motifs and identify mechanisms that potentially influence the expression of K(V)1.5 channel expression.

  19. Kv1.5 has a role in Rab-GTPase-dependent endocytic recycling in atrial myocytes

  20. These results suggest that the inhibition of K(v) channel expression and rise in [Ca(2+)](i) during chronic hypoxia may be the result of HIF-1-dependent induction of ET-1.

Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5) profil antigène

Profil protéine

Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7).

Gene names and symbols associated with KCNA5

  • potassium voltage-gated channel subfamily A member 5 (KCNA5) anticorps
  • potassium channel, voltage gated shaker related subfamily A, member 5 (kcna5) anticorps
  • potassium voltage-gated channel, shaker-related subfamily, member 5 (Kcna5) anticorps
  • potassium voltage-gated channel subfamily A member 5 (Kcna5) anticorps
  • ATFB7 anticorps
  • HCK1 anticorps
  • HK2 anticorps
  • HPCN1 anticorps
  • kcna5 anticorps
  • Kv1 anticorps
  • Kv1.5 anticorps
  • PCN1 anticorps

Protein level used designations for KCNA5

potassium voltage-gated channel, shaker-related subfamily, member 5 , potassium voltage-gated channel subfamily A member 5-like , cardiac potassium channel , insulinoma and islet potassium channel , potassium channel 1 , potassium voltage-gated channel subfamily A member 5 , voltage-gated potassium channel HK2 , voltage-gated potassium channel protein Kv1.5 , voltage-gated potassium channel subunit Kv1.5 , KV1-5 , Potassium (K+) channel protein alpha 5 , RCK7 , RK4 , potassium voltage gated channel, shaker related subfamily, member 5 , shaker subfamily potassium channel Kv1.5 alpha subunit , delayed rectifier K+ channel , Kv1.5 potassium channel , potassium voltage-gated channel shaker-related subfamily member 5 , potassium voltage-gated channel shaker-related subfamily 5 , potassium channel Kv1.5 , voltage-gated potassium channel Kv1.5

GENE ID SPECIES
466930 Pan troglodytes
496997 Xenopus (Silurana) tropicalis
100431806 Pongo abelii
3741 Homo sapiens
16493 Mus musculus
25470 Rattus norvegicus
395115 Gallus gallus
403995 Canis lupus familiaris
474166 Sus scrofa
508960 Bos taurus
100008684 Oryctolagus cuniculus
Fournisseurs de qualité sélectionnés pour anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5) Anticorps
Avez-vous cherché autre chose?