Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) Kits ELISA

PBX1 encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. De plus, nous expédions PBX1 Anticorps (75) et PBX1 Protéines (7) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
PBX1 5087 P40424
PBX1 18514 P41778
Anti-Rat PBX1 PBX1 304947  
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Top PBX1 Kits ELISA sur anticorps-enligne.fr

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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Souris < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
$810.17
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Humain < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
$810.17
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Plus Kits ELISA pour PBX1 partenaires d'interaction

Human Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. Our results indicate an important influence of the neurodevelopment genes, PBX1, LMX1A, and SLITRK1 in obsessive-compulsive disorder susceptibility

  2. PBX1 plays an oncogenic role in clear cell renal carcinoma via JAK2/STAT3 pathway

  3. B-cell acute lymphoblastic leukemia patients with positive E2A-PBX1 fusion expression after transplant will have a poor prognosis.

  4. Expression of PBX1 in leukemia cells enhances chemo-resistance and colony formation.

  5. The sequence variants in our cases included missense substitutions adjacent to the PBX1 homeodomain (p.Arg184Pro, p.Met224Lys, and p.Arg227Pro) or within the homeodomain (p.Arg234Pro, and p.Arg235Gln), whereas p.Ser262Glnfs*2, and p.Arg288* yielded truncated PBX1 proteins.

  6. PBX1 is one of the determinants in the Cx32 promoter targeting site, preventing further damage of gap junction protein in H. pylori-associated gastric carcinogenesis.

  7. A hydrophobic residue in the TALE homeodomain of PBX1 promotes epithelial-to-mesenchymal transition of gastric carcinoma

  8. PBX1 haploinsufficiency leads to syndromic CAKUT.

  9. This is the first time the protein partners of either E2A-PBX1 or HOXA9 oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 might indicate a novel function for HOX proteins independent of their transcriptional activity.

  10. involved in monogenic anomalies of kidney and urinary tract

  11. these results confirm that PBX1 directly regulates genes related to T cell activation and shows that the lupus-associated isoform PBX1-d has unique molecular functions.

  12. the PBX1 binding motif at its promoter acted to positively regulate STAT3 transcription.

  13. Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4(+) T cell effector function

  14. Notably, PBX1 and NFE2L1 levels are severely reduced in dopaminergic neurons of the substantia nigra of Parkinson's disease (PD) patients and decreased NFE2L1 levels increases damage by oxidative stress in human midbrain cells.

  15. PBX1 overexpression in MCF10A cells up-regulated most LiMe genes.

  16. results indicate that E2A-PBX1 cooperates with additional gene alterations to develop acute lymphoblastic leukemia; among them, enhanced expression of ZNF521 may play a clinically relevant role in E2A fusion genes to develop B-lineage ALL

  17. Review of the role of the E2A-PBX1 gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.

  18. This study thus suggests that RNF6 overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 axis can be developed as a novel therapeutic target of leukemia.

  19. Data identifies PBX1 amplification as a functional hallmark of aggressive ERalpha-positive breast cancers.

  20. We observed significant enrichment of the neuroactive ligand-receptor interaction pathway in TCF3-PBX1 as well as an enrichment of genes involved in immunity and infection pathways in ETV6-RUNX1 subtype

Zebrafish Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. findings suggest that pbx1 may be required during the late stage of swim bladder development

Mouse (Murine) Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. a mechanism by which the DNA binding-independent activity of Sp2 potentiates genomic loading of Pbx1:Prep1 and Nf-y to composite motifs present in many promoters of highly expressed genes

  2. uc.40 may play an important role during the differentiation of P19 cells by regulation of PBX1 to promote proliferation and inhibit apoptosis.

  3. Expression of PBX1 in leukemia cells enhances chemo-resistance and colony formation.

  4. Pbx-dependent Epithelial-mesenchymal transition programs mediate murine upper lip/primary palate morphogenesis and fusion via regulation of Snail1.

  5. MEIS2 associates with chromatin-bound PBX1, recruits PARP1/ARTD1, and initiates PARP1-mediated eviction of H1 from the chromatin fiber.

  6. results indicate Pbx genes act in parallel genetic pathways to orchestrate neuronal subtype differentiation, connectivity, and organization. I

  7. Hoxa2, Meis and Pbx proteins act cooperatively on the ECR, via a core 32 bp sequence, to regulate Hmx1 expression.

  8. PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2.

  9. Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation and promoting follicular helper T cells at the expense of regulatory T cell s and identify Pbx1 as a novel regulator of CD4(+) T cell effector function

  10. FLT3-ITD is capable of inhibiting FLT3-ITD+ cell proliferation through the p21/Pbx1 axis

  11. non-cell autonomous functions of Pbx factors within the splenic niche contribute to the regulation of hematopoiesis

  12. Both histone H3 lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2.

  13. Thus, PTBP1 controls the activity of Pbx1 to suppress its neuronal transcriptional program prior to induction of neuronal progenitor cells development.

  14. this study showed that the lupus susceptibility gene Pbx1 not only contributes to autoimmune pathology by impairing T cell tolerance, but also impairs the function of mesenchymal stem cells, which may also contribute to the disease directly or indirectly.

  15. Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning.

  16. Results thus show how Pbx1 controls Fgf10 in the developing lung.

  17. Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.

  18. These results demonstrate a role for Pbx1 in restraining myeloid maturation while maintaining lymphoid potential to appropriately regulate progenitor reservoirs.

  19. The Systemic Lupus Erythematosus-associated Pbx1-d isoform acts as a dominant-negative transcriptional regulator.

  20. Data have demonstrated the presence of Meis, Pbx, and Prep proteins during early lineage segregation in mammals: Meis1, Meis3, Pbx1, Pbx2, Pbx3, and Prep1 in the mouse.

Xenopus laevis Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) interaction partners

  1. Pbx transcription factor plays a crucial role in Xenopus lens development

  2. These overall data suggest that ZFPIP and Pbx1 could be partners and cooperate in the regulation of essential neural genes during Xenopus development.

PBX1 profil antigène

Antigen Summary

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1\;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PBX1

  • PBX homeobox 1 (PBX1) anticorps
  • pre-B-cell leukemia homeobox 1a (pbx1a) anticorps
  • pre B cell leukemia homeobox 1 (Pbx1) anticorps
  • PBX homeobox 1 (Pbx1) anticorps
  • pre-B-cell leukemia homeobox 1 S homeolog (pbx1.S) anticorps
  • 2310056B04Rik anticorps
  • AI848790 anticorps
  • AU015730 anticorps
  • D230003C07Rik anticorps
  • fi29e01 anticorps
  • Pbx-1 anticorps
  • PBX1A anticorps
  • Pbx1b anticorps
  • wu:fi29e01 anticorps
  • Xpbx1 anticorps
  • Xpbx1b anticorps
  • zgc:55265 anticorps

Protein level used designations for PBX1

homeobox protein PBX1 , homeobox protein PRL , pre-B-cell leukemia transcription factor 1 , pre-B-cell leukemia transcription factor 1b , pre B-cell leukemia transcription factor 1 , Homeobox protein pbx1

GENE ID SPECIES
5087 Homo sapiens
58138 Danio rerio
18514 Mus musculus
304947 Rattus norvegicus
395505 Gallus gallus
488669 Canis lupus familiaris
540688 Bos taurus
399184 Xenopus laevis
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