Pregnancy-Associated Plasma Protein A, Pappalysin 1 Protéines (PAPPA)

PAPPA encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). De plus, nous expédions PAPPA Anticorps (232) et PAPPA Kits (26) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PAPPA 18491 Q8R4K8
Rat PAPPA PAPPA 313262  
PAPPA 5069 Q13219
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Showing 10 out of 22 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Escherichia coli (E. coli) Humain His tag 100 μg 15 to 18 Days
Escherichia coli (E. coli) Souris His tag,GST tag 100 μg 15 to 18 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Escherichia coli (E. coli) Humain Inconjugué 10 μg 11 to 12 Days
Escherichia coli (E. coli) Humain His tag   50 μg 15 to 18 Days
Escherichia coli (E. coli) Humain His tag   1 mg 2 to 3 Days
Human Humain Inconjugué   100 μg 11 to 16 Days

PAPPA Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) ,
Human , , , ,
, ,

Plus protéines pour Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) partenaires d'interaction

Mouse (Murine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. Inducible knockdown of PAPP-A gene expression in adult female mice extends life span.

  2. Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A KO compared to WT mice. Moreover, 18-month-old PAPP-A KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A deficiency in mice is associated with indices of healthy skeletal muscle function with age.

  3. Snell, GHKRO, and PAPPA-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1).

  4. STC2 is involved in regulating PAPP-A activity during the development of atherosclerosis

  5. Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A.

  6. stimulation of PAPP-A expression by intermittent PTH treatment contributes to PTH bone anabolism in mice

  7. PAPP-A affects fascicle structure, thereby affecting tendon phenotype.

  8. tissue-specific expression differentially affected during aging

  9. PAPP-A has a role in development of advanced plaque with necrotic cores and buried fibrous caps in the brachiocephalic artery

  10. these data indicate preferential impact of PAPP-A deficiency on visceral fat in the mouse that is associated with enhanced insulin receptor signaling

  11. Studies show a conditional PAPP-A knockout (KO) model for efficacy of tamoxifen-induced floxed PAPP-A excision in various tissues and indicate a significant reduction of neointimal formation after unilateral carotid artery ligation.

  12. absence of PAPP-A is associated with resistance to the development of indicators of diabetic nephropathy in mice

  13. Pregnancy-associated plasma protein (PAPP)-A expressed in the mammary gland controls epithelial cell proliferation and differentiation.

  14. Data conclude that PAPP-A proteolytic activity is required for the lesion-promoting effect of PAPP-A and that its specificity must be directed against IGFBP-4.

  15. observations revealed a novel function of prohibitin as a chaperone of p53. Further, they suggest that binding of denatured p53 in intron 1 causes an enhancer effect and increases the transcription of PAPP-A

  16. PAPP-A increases bone formation primarily by increasing IGF bioavailability and other alternative pathways may play a negligible role in mediating the anabolic effect of PAPPA in bone.

  17. PAPPA modulates ovarian function and female fertility by controlling the bioavailability of ovarian insulin-like growth factors.

  18. Renal expression of Irs1 and Mt1 was increased by PappA(-/-) as well as by mutations that reduce IGF-1 in serum.

  19. Major contributors to extended life span of PAPP-A knockout mice are delayed occurrence of fatal neoplasias and decreased incidence of age-related degenerative changes.

  20. gonadotropin-stimulated PAPP-A gene expression plays a role in the follicle development, ovulation, and luteogenesis in the mammalian ovary

Human Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. Pregnancy-associated plasma protein-A has a role in atherosclerosis [review]

  2. PAPP-A serum concentration does not seem to be a useful biomarker in clear cell renal cell carcinoma.

  3. higher serum levels in obstructive sleep apnea syndrome (OSAS) patients show inflammatory component in OSAS

  4. In STEMI patients, Stanniocalcin-2 and IGFBP-4 emerged as independent predictors of all-cause death and readmission due to HF. The Stanniocalcin-2/PAPP-A/IGFBP-4 axis exhibits a significant role in STEMI risk stratification.

  5. In summary, this study suggests that PAPPA is essential to maintain a receptive endometrium by up-regulating N-fucosylation, which is a potential useful biomarker to evaluate the receptive functions of the endometrium.

  6. Serum PAPP-A at third trimester of pregnancy was not associated with late-onset pre-eclampsia and intrauterine growth retardation after 34weeks of pregnancy.

  7. Elevated PROK1 in the first pregnancy trimester is a more effective marker than PAPP-A in the prediction of pre-eclampsia and fetal growth restriction.

  8. The findings suggest a possible pathophysiological link between the development of Fetal growth restriction and the expression of PAPPA, PAPPA2 and PLAC-1.

  9. Data suggest that PGF and PAPPA serve as serum biomarkers for early diagnosis of gestational hypertension. These studies were conducted at antenatal clinics in Ghana using blood from women between 8 and 13 weeks gestation. (PGF = placental growth factor; PAPPA = pregnancy-associated plasma protein-A)

  10. Pregnancy associated plasma protein-A (PAPP-A) appears to be a potentially useful biomarker for short-term risk stratification of patients presenting with chest pain of ischemic origin (Review).

  11. These data suggested that hsa_circ_0004904 and hsa_circ_0001855 combined with PAPP-A might be promising biomarkers for the detection of Preeclampsia. Bioinformatics analysis predicted that hsa_circ_0004904 and hsa_circ_0001855 miRNA sponges directly target PAPP-A.

  12. higher first trimester serum values seem to be associated with placenta accreta in women with placenta previa

  13. Studied the role of pregnancy-associated plasma protein A (PAPP-A) in the outcome of ischemic cerebrovascular disease.

  14. maternal serum levels associated with small for gestational age neonates, preterm birth, and pre-eclampsia

  15. PAPP-A and ProMBP are associated with increased risk of death in heart failure patients.

  16. low levels not associated with high serum estradiol at controlled ovarian stimulation

  17. PAPP-A C/C genotypes were more frequent among mothers with gestational diabetes than in control.

  18. Elevated PAPP-A compared to other risk factors was a stronger predictor for future CV events 2 years post ACS in patients with type 2 diabetes mellitus.

  19. PAPP-A, like CCS and CIMT, is a parameter that can be used to detect subclinical atherosclerosis.

  20. Results suggest that links between PAPP-A concentrations in early pregnancy and subsequent glucose concentrations and blood pressures may be mediated by changes in insulin sensitivity (and secretion).

Cow (Bovine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. study determined IGFR1 and PAPP-A expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A secretion as a modulator of IGF1 in cattle with COD

  2. in preovulatory follicles, PAPP-A is responsible for IGF-dependent IGFBP-2 degradation

  3. concluded that changes in granulosa cell PAPP-A mRNA levels do not occur during final preovulatory follicular development in cattle

Profil protéine PAPPA

Profil protéine

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.

Gene names and symbols associated with PAPPA

  • pappalysin 1 (PAPPA)
  • pregnancy-associated plasma protein A (Pappa)
  • pappalysin 1 (Pappa1)
  • pappalysin 1 (Pappa)
  • 8430414N03Rik Protéine
  • ASBABP2 Protéine
  • DIPLA1 Protéine
  • IGFBP-4ase Protéine
  • PAG1 Protéine
  • PAPA Protéine
  • PAPP-A Protéine
  • Pappa Protéine
  • PAPPA1 Protéine

Protein level used designations for PAPPA

IGF-dependent IGFBP-4 protease , insulin-like growth factor-dependent IGF-binding protein 4 protease , pappalysin-1 , aspecific BCL2 ARE-binding protein 2 , differentially placenta 1 expressed protein , insulin-like growth factor-dependent IGF binding protein-4 protease , pregnacy-associated plasma protein A , PAPPA-like protein , pregnancy-associated plasma protein A-like protein , cleaves insulin-like binding protein-4 (IGFBP-4) , metalloprotease

100033920 Equus caballus
18491 Mus musculus
313262 Rattus norvegicus
5069 Homo sapiens
481692 Canis lupus familiaris
282647 Bos taurus
100734958 Cavia porcellus
417245 Gallus gallus
397219 Sus scrofa
443157 Ovis aries
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